Advertisement

Cell Biochemistry and Biophysics

, Volume 67, Issue 3, pp 1473–1479 | Cite as

Platelet Changes in Acute Leukemia

  • Xu Qian
  • Liu Wen-jun
Translational Biomedical Research

Abstract

Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal proliferation of leukemic and immature cells that suppress the production of normal blood cells and extensively invade peripheral tissues. The bleeding complications are very common in acute leukemia and often lead to death. One major cause for hemorrhage is thrombocytopenia, which is caused by the replacement of normal bone marrow cells with leukemic cells and the inhibition of megakaryocytes functions. Declines in platelet count as well as in function in acute leukemia have been reported in many studies. Here, we reviewed the literatures concerning platelet changes in acute leukemia.

Keywords

Changes of platelet  Acute leukemia  Research progress 

Notes

Acknowledgments

We are thankful to the Education Bureau of Sichuan Province for financial support (Grant No. 11ZA150).

Conflict of interest

Authors have no conflict of interest.

References

  1. 1.
    Deutsch, V., Katz, B. Z., & Tomer, A. (2010). Megakaryocyte development and platelet production in normal and disease states. Harefuah, 149(291–297), 336.Google Scholar
  2. 2.
    Vladareanu, A. M., Vasilache, V., Bumbea, H., & Onisai, M. (2011). Platelet dysfunction in acute leukemias and myelodysplastic syndromes. Romanian Journal of Internal Medicine, 49, 93–96.PubMedGoogle Scholar
  3. 3.
    Sharma, S., Purohit, A., Pati, H. P., & Kochupillai, V. (2011). Platelet enzyme abnormalities in leukemias. Indian Journal of Cancer, 48, 323–327.PubMedCrossRefGoogle Scholar
  4. 4.
    Ntaios, G., Papadopoulos, A., Chatzinikolaou, A., Saouli, Z., Karalazou, P., Kaiafa, G., et al. (2008). Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpura. Acta Haematologica, 119, 173–177.PubMedCrossRefGoogle Scholar
  5. 5.
    Alsweedan, S. A., Al-Shurman, A., & Mahmoud, A. S. (2008). Diagnostic value of platelet indices in children with leukemia. Journal of Pediatric Hematology/Oncology, 30, 953–955.PubMedCrossRefGoogle Scholar
  6. 6.
    Lee, W. S., & Kim, T. Y. (2010). Platelet indices are not suitable for screening of leukemia. Journal of Pediatric Hematology/Oncology, 32, 251.PubMedCrossRefGoogle Scholar
  7. 7.
    Banfi, G., & Germagnoli, L. (2008). Preanalytical phase in haematology. Journal of Medical Biochemistry, 27, 348–353.CrossRefGoogle Scholar
  8. 8.
    Zeidler, L., Zimmermann, M., Moricke, A., Meissner, B., Bartels, D., Tschan, C., et al. (2012). Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome. Haematologica, 97, 402–409.PubMedCrossRefGoogle Scholar
  9. 9.
    Alatrash, G., Pelosini, M., Saliba, R. M., Koca, E., Rondon, G., Andersson, B. S., et al. (2011). Platelet recovery before allogeneic stem cell transplantation predicts posttransplantation outcomes in patients with acute myelogenous leukemia and myelodysplastic syndrome. Biology of Blood and Marrow Transplantation, 17, 1841–1845.PubMedCrossRefGoogle Scholar
  10. 10.
    Psaila, B., Bussel, J. B., Frelinger, A. L., Babula, B., Linden, M. D., Li, Y., et al. (2001). Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia. Journal of Thrombosis and Haemostasis, 9, 2302–2310.CrossRefGoogle Scholar
  11. 11.
    Strauss, G., Vollert, C., von Stackelberg, A., Weimann, A., Gaedicke, G., & Schulze, H. (2011). Immature platelet count: A simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatric Blood & Cancer, 57, 641–647.CrossRefGoogle Scholar
  12. 12.
    Liu, Y., Wang, Z., Yuan, B. X., Wang, X. Y., Wu, Q., & Yuan, H. (2011). Role of reticulated platelets and platelet-associated antibody in differential diagnosis of idiopathic thrombocytopenic purpura. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 19, 979–982.PubMedGoogle Scholar
  13. 13.
    Cannavo, I., Ferrero-Vacher, C., Sudaka, I., Aquaronne, D., Berthier, F., & Raynaud, S. (2010). Assessment of an immature platelet fraction (IFP%) in the diagnosis of thrombocytopenia. Annales de Biologie Clinique, 68, 415–420.PubMedGoogle Scholar
  14. 14.
    Chaoui, D., Chakroun, T., Robert, F., Rio, B., Belhocine, R., Legrand, O., et al. (2005). Reticulated platelets: A reliable measure to reduce prophylactic platelet transfusions after intensive chemotherapy. Transfusion, 45, 766–772.PubMedCrossRefGoogle Scholar
  15. 15.
    Ryningen, A., Apelseth, T., Hausken, T., & Bruserud, O. (2006). Reticulated platelets are increased in chronic myeloproliferative disorders, pure erythrocytosis, reactive thrombocytosis and prior to hematopoietic reconstitution after intensive chemotherapy. Platelets, 17, 296–302.PubMedCrossRefGoogle Scholar
  16. 16.
    Michur, H., Maslanka, K., Szczepinski, A., & Marianska, B. (2008). Reticulated platelets as a marker of platelet recovery after allogeneic stem cell transplantation. International Journal of Laboratory Hematology, 30, 519–525.PubMedGoogle Scholar
  17. 17.
    Kaplan, Z. S., & Jackson, S. P. (2011). The role of platelets in atherothrombosis. Hematology/the Education Program of the American Society of Hematology American Society of Hematology Education Program, 2011, 51–61.PubMedCrossRefGoogle Scholar
  18. 18.
    Seidl, C., Siehl, J., Ganser, A., Hofmann, W. K., Fischer, M., Kirchmaier, C. M., et al. (2000). Platelet glycoprotein expression in patients with myelodysplastic syndrome. Thrombosis Research, 2000(100), 27–34.CrossRefGoogle Scholar
  19. 19.
    Popov, V., Vladareanu, A., Bumbea, H., Radesi, S., Iordache, M., Kovacs, E., et al. (2010). Membrane fluidity’s role in platelet function in patients with myeloproliferative neoplasms. Blood (ASH Annual Meeting Abstracts), 116, Abstract 5125.Google Scholar
  20. 20.
    Jaime-Perez, J. C., Cantu-Rodriguez, O. G., Herrera-Garza, J. L., & Gomez-Almaguer, D. (2004). Platelet aggregation in children with acute lymphoblastic leukemia during induction of remission therapy. Archives of Medical Research, 35, 141–144.PubMedCrossRefGoogle Scholar
  21. 21.
    Girtovitis, F. I., Ntaios, G., Papadopoulos, A., Ioannidis, G., & Makris, P. E. (2007). Defective platelet aggregation in myelodysplastic syndromes. Acta Haematologica, 118, 117–122.PubMedCrossRefGoogle Scholar
  22. 22.
    Luo, W. D., Chen, B. G., Men, Z. F., Li, B. L., Zhu, M., & Guo, Q. Y. (2005). Study on platelet activated state and platelet activated function in adults with acute leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 13, 452–455.PubMedGoogle Scholar
  23. 23.
    Foss, B., & Bruserud, O. (2008). Platelet functions and clinical effects in acute myelogenous leukemia. Thrombosis and Haemostasis, 99, 27–37.PubMedGoogle Scholar
  24. 24.
    Shi, L., Zhang, J., Wu, P., Feng, K., Li, J., Xie, Z., et al. (2009). Discovery and identification of potential biomarkers of pediatric acute lymphoblastic leukemia. Proteome Science, 7, 7.PubMedCrossRefGoogle Scholar
  25. 25.
    Kim, J. Y., Song, H. J., Lim, H. J., Shin, M. G., Kim, J. S., Kim, H. J., et al. (2008). Platelet factor-4 is an indicator of blood count recovery in acute myeloid leukemia patients in complete remission. Molecular and Cellular Proteomics, 7, 431–441.PubMedCrossRefGoogle Scholar
  26. 26.
    Giordano, P., Molinari, A. C., Del Vecchio, G. C., Saracco, P., Russo, G., Altomare, M., et al. (2010). Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia. American Journal of Hematology, 85, 325–330.PubMedGoogle Scholar
  27. 27.
    Leinoe, E. B., Hoffmann, M. H., Kjaersgaard, E., Nielsen, J. D., Bergmann, O. J., Klausen, T. W., et al. (2005). Prediction of haemorrhage in the early stage of acute myeloid leukaemia by flow cytometric analysis of platelet function. British Journal of Haematology, 128, 526–532.PubMedCrossRefGoogle Scholar
  28. 28.
    Foss, B., Ulvestad, E., Hervig, T., & Bruserud, O. (2002). Effects of cytarabine and various anthracycline on platelet activation: Characterization of in vitro effects and their possible clinical relevance in acute myelogenous leukemia. International Journal of Cancer, 97, 106–114.CrossRefGoogle Scholar
  29. 29.
    Erpenbeck, L., & Schon, M. P. (2010). Deadly allies: The fatal interplay between platelets and metastasizing cancer cells. Blood, 115, 3427–3436.PubMedCrossRefGoogle Scholar
  30. 30.
    Bistrian, R., Dorn, A., Mobest, D. C., Ruster, B., Ludwig, R., Scheele, J., et al. (2009). Shear stress-mediated adhesion of acute myeloid leukemia and KG-1 cells to endothelial cells involves functional P-selectin. Stem Cells and Development, 18, 1235–1242.PubMedCrossRefGoogle Scholar
  31. 31.
    Walenkamp, A. M., Bestebroer, J., Boer, I. G., Kruizinga, R., Verheul, H. M., van Strijp, J. A., et al. (2010). Staphylococcal SSL5 binding to human leukemia cells inhibits cell adhesion to endothelial cells and platelets. Cellular Oncology, 32, 1–10.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PediatricsAffiliated Hospital of Luzhou Medical CollegeLuzhouChina

Personalised recommendations