Cell Biochemistry and Biophysics

, Volume 67, Issue 3, pp 1473–1479 | Cite as

Platelet Changes in Acute Leukemia

  • Xu Qian
  • Liu Wen-jun
Translational Biomedical Research


Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal proliferation of leukemic and immature cells that suppress the production of normal blood cells and extensively invade peripheral tissues. The bleeding complications are very common in acute leukemia and often lead to death. One major cause for hemorrhage is thrombocytopenia, which is caused by the replacement of normal bone marrow cells with leukemic cells and the inhibition of megakaryocytes functions. Declines in platelet count as well as in function in acute leukemia have been reported in many studies. Here, we reviewed the literatures concerning platelet changes in acute leukemia.


Changes of platelet  Acute leukemia  Research progress 



We are thankful to the Education Bureau of Sichuan Province for financial support (Grant No. 11ZA150).

Conflict of interest

Authors have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PediatricsAffiliated Hospital of Luzhou Medical CollegeLuzhouChina

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