Cell Biochemistry and Biophysics

, Volume 67, Issue 3, pp 1029–1032 | Cite as

A Resting-State Functional Magnetic Resonance Imaging Study of Acute Carbon Monoxide Poisoning in Humans

Original Paper

Abstract

The objective of this study was to evaluate the brain function characteristics of carbon monoxide poisoning patients using resting-state functional magnetic resonance imaging (fMRI) method. For this purpose, 12 carbon monoxide poisoning patients and healthy controls were subjected to resting-state fMRI scans separately. A regional homogeneity (ReHo) approach was used to analyze the brain function in carbon monoxide poisoning patients. Compared with control group, the value of ReHo in carbon monoxide poisoning group showed distinct decrease in bilateral superior frontal gyrus, middle frontal gyrus, right cuneus, left middle temporal gyrus, right insula, and cerebellum. Therefore, it was concluded that the brain functions in carbon monoxide poisoning patients were abnormal under the resting-state. The cuneate lobe function may indicate the degree of brain hypoxia and strengthening the cerebellar function training may promote the rehabilitation process.

Keywords

Acute carbon monoxide poisoning Magnetic resonance imaging Resting-state Regional homogeneity 

References

  1. 1.
    Weaver, L. K., Hopkins, R. O., Chan, K. J., et al. (2002). Hyperbaric oxygen for acute carbon monoxide poisoning. The New England Journal of Medicine, 347, 1057–1067.PubMedCrossRefGoogle Scholar
  2. 2.
    Goldstein, M. (2008). Carbon monoxide poisoning. Journal of Emergency Nursing, 34, 538–542.PubMedCrossRefGoogle Scholar
  3. 3.
    Hopkins, R. O., & Woon, F. L. (2006). Neuroimaging, cognitive, and neurobehavioral outcomes following carbon monoxide poisoning. Behavioral and Cognitive Neuroscience Reviews, 5, 141–155.PubMedCrossRefGoogle Scholar
  4. 4.
    Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004). Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI. Proceedings of the National Academy of Sciences of the United States of America, 101, 4637–4642.PubMedCrossRefGoogle Scholar
  5. 5.
    O’Donnell, P., Buxton, P. J., Pitkin, A., & Jarvis, L. J. (2000). The magnetic resonance imaging appearances of the brain in acute carbon monoxide poising. Clinical Radiology, 9, 273–280.CrossRefGoogle Scholar
  6. 6.
    Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 4259–4264.PubMedCrossRefGoogle Scholar
  7. 7.
    Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain, 129, 564–583.PubMedCrossRefGoogle Scholar
  8. 8.
    Laureys, S., Goldman, S., Phillips, C., et al. (1999). Impaired effective cortical connectivity in vegetative state. NeuroImage, 9, 377–382.PubMedCrossRefGoogle Scholar
  9. 9.
    Beiser, D. G., Hua, S. E., & Houk, J. C. (1997). Network models of the basal ganglia. Current Opinion in Neurobiology, 7, 185–190.PubMedCrossRefGoogle Scholar
  10. 10.
    Middleton, F. A., & Strick, P. L. (1994). Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science, 266, 458–461.PubMedCrossRefGoogle Scholar
  11. 11.
    Small, S. L., Hlustik, P., Noll, D. C., Genovese, C., & Solodkin, A. (2002). Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain, 125, 1544–1557.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Liu Dinghua
    • 1
  • Liu Dongbo
    • 1
  • Zhang Jianyu
    • 1
  • Peng Lan
    • 1
  1. 1.Department of NeurologyAffiliated Jiangyin Hospital of Southeast University Medical CollegeJiangyinChina

Personalised recommendations