Cell Biochemistry and Biophysics

, Volume 61, Issue 3, pp 699–701 | Cite as

Drug-Indiced Aseptic Meningitis: Development of Subacute Sclerosing Panencephalitis Following Repeated Intraventricular Infusion Therapy with Interferon Alpha/Beta

  • George ImatakaEmail author
  • Eiji Nakagawa
  • Hideo Yamanouchi
  • Osamu Arisaka
Translational Biomedical Research


Interferon (IFN)-α was reported to be effective in longterm intrathecal treatment of subacute sclerosing panencephalitis (SSPE). However, the side effects related with longterm use of IFN-α/β are unclear. We evaluated the therapeutic effects of IFN-α/β in a 13-years-old patient with SSPE. The cerebrospinal fluid (CSF) measles antibody titer was 64 × NT/128×HI, IgG-index was 4.5, and the SSPE diagnosis was based on electroencephalography (Jabbour-stage II on admission). With Inosiplex (INP) given orally, IFN-α (3 × 106 units) was infused intraventricularly twice-a-week for 1-year. Resultantly, CSF cell count was elevated (2502/3), total protein and glucose levels were normal; however, DIAM occurred repeatedly. Consequently, reduced IFN-α (5 × 105 units) with hydrocorton was administered at 2-months interval for 19 months, during which, DIAM occurred four times. Therefore, IFN-β (3 × 106 units; twice-a-week) therapy was started and continued for 3 years. Although the symptoms were improved considerably, DIAM recurred after 15-months therapy and CSF cell counts were also elevated (2121/3). Since SSPE progressed to Jabbour-stage IV, indicated by irreversible consciousness disorder, IFN therapy was discontinued and INP monotherapy was followed for another 3 years. We, therefore, concluded that the longterm intraventricular IFN-α/β infusion therapy of SSPE involved the potential risk of DIAM with serious irreversible neurological sequelae and should be monitored carefully.


Systemic Lupus Erythematosus Kawasaki Disease Aseptic Meningitis Ommaya Reservoir Subacute Sclerosing Panencephalitis 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • George Imataka
    • 1
    Email author
  • Eiji Nakagawa
    • 2
  • Hideo Yamanouchi
    • 3
  • Osamu Arisaka
    • 1
  1. 1.Department of PediatricsDokkyo Medical University School of MedicineMibuJapan
  2. 2.Department of Pediatric NeurologyNational Center of Neurology and Psychiatry, Musashi HospitalKodairaJapan
  3. 3.Department of PediatricsSaitama Medical University School of Medicine SaitamaJapan

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