Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature
5-Fluorouracil is a key element to the treatment of colon cancer. But it is also one of the most cardiotoxic chemotherapies, and the management of those that experience cardiotoxicity can be challenging. We present three cases of 5-FU cardiac toxicity that manifested as myocardial infarction, cardiogenic shock, and ventricular fibrillation. Additionally, we discuss the current literature regarding 5-fluorouracil cardiotoxicity mechanisms as well as management.
KeywordsCardiotoxicity Pharmacotherapy Chemotherapy 5-Fluorouracil Acute myocardial infarction Cardiogenic shock Ventricular fibrillation Arrhythmia Colon cancer
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Arney, K. (2016). “Fluorouracil”. Chemistry World. Audio blog post. Royal Society of Chemistry. https://www.chemistryworld.com/podcasts/fluorouracil/1017474.article.Google Scholar
- 19.Porschen, R., Arkenau, H. T., Kubicka, S., et al. (2007). Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO Colorectal Study Group. Journal of Clinical Oncology,25(27), 4217.CrossRefGoogle Scholar