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Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning

  • Chien-Cheng Huang
  • Chung-Han Ho
  • Yi-Chen Chen
  • Chien-Chin Hsu
  • Hung-Jung Lin
  • Jhi-Joung Wang
  • Shih-Bin Su
  • How-Ran GuoEmail author
Article
  • 44 Downloads

Abstract

Carbon monoxide poisoning (COP) may increase the risk of myocardial infarction. We conducted a study to investigate the effects of hyperbaric oxygen therapy (HBOT) on the risk. We used the Nationwide Poisoning Database in Taiwan to identify COP patients diagnosed between 1999 and 2012. We compared the risk for myocardial infarction between patients with and without HBOT by following up through 2013 and identified the independent predictors of myocardial infarction. The risk of myocardial infarction in the 7278 patients with HBOT was lower than in the 18,459 patients without HBOT, but this difference did not reach statistical significance [adjusted hazard ratio (AHR): 0.69; 95% confidence interval (CI) 0.45–1.07]. Stratified analyses showed that the reductions in the risk associated with HBOT for myocardial infarction reached statistical significance in male patients (AHR: 0.45; 95% CI 0.24–0.83) and during the first 2 weeks of follow-up (AHR: 0.22; 95% CI 0.05–0.96). In patients without HBOT, independent predictors of myocardial infarction were old age, male sex, and the underlying comorbidities of hypertension, diabetes, coronary artery disease, and congestive heart failure. In patients with HBOT, however, old age, male sex, and the underlying comorbidities of diabetes, coronary artery disease, and congestive heart failure were not independent predictors. HBOT was associated with a reduced risk of myocardial infarction in male patients and within 2 weeks following COP. These results may provide important reference for using HBOT in treating COP.

Keywords

Carbon monoxide Hyperbaric oxygen therapy Myocardial infarction Poisoning 

Abbreviations

COP

Carbon monoxide poisoning

HBOT

Hyperbaric oxygen therapy

AHR

Adjusted hazard ratio

CI

Confidence interval

CO

Carbon monoxide

NPD

National Poisoning Database

NHIRD

National Health Insurance Research Database

ICD-9-CM

International Classification of Diseases, Ninth Revision, Clinical Modification

HIV

Human immunodeficiency virus

Notes

Author Contributions

C-CH and H-RG designed and conceived this study and wrote the manuscript. H-CH and Y-CC performed the statistical analysis and wrote the manuscript. H-JL, C-CH, J-JW, and S-BS provided professional suggestions and wrote the manuscript. All the authors have read and approved the final manuscript.

Funding

This study was supported by Grant MOST 108-2638-B-006-001-MY2 from the Ministry of Science and Technology and Grants CMFHR10677 and CMFHR10734 from the Chi-Mei Medical Center.

Compliance with Ethical Standards

Ethical Approval and Consent to Participate

This study was conducted in strict accordance with the Declaration of Helsinki and was approved by the Institutional Review Board at the Chi-Mei Medical Center. The two databases used in this study consisted of depersonalized information, and so the informed consent was waived as the study did not affect the welfare of the participants.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Emergency MedicineChi-Mei Medical CenterTainanTaiwan
  2. 2.Department of Environmental and Occupational Health, College of MedicineNational Cheng Kung UniversityTainanTaiwan
  3. 3.Department of Senior ServicesSouthern Taiwan University of Science and TechnologyTainanTaiwan
  4. 4.Department of Medical ResearchChi-Mei Medical CenterTainanTaiwan
  5. 5.Department of Hospital and Health Care AdministrationChia Nan University of Pharmacy and ScienceTainanTaiwan
  6. 6.Department of BiotechnologySouthern Taiwan University of Science and TechnologyTainanTaiwan
  7. 7.Department of Emergency MedicineTaipei Medical UniversityTaipeiTaiwan
  8. 8.Department of Occupational MedicineChi-Mei Medical CenterTainanTaiwan
  9. 9.Department of Leisure, Recreation and Tourism ManagementSouthern Taiwan University of Science and TechnologyTainanTaiwan
  10. 10.Department of Medical ResearchChi-Mei Medical CenterTainanTaiwan
  11. 11.Department of Occupational and Environmental MedicineNational Cheng Kung University HospitalTainanTaiwan

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