Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning
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Carbon monoxide poisoning (COP) may increase the risk of myocardial infarction. We conducted a study to investigate the effects of hyperbaric oxygen therapy (HBOT) on the risk. We used the Nationwide Poisoning Database in Taiwan to identify COP patients diagnosed between 1999 and 2012. We compared the risk for myocardial infarction between patients with and without HBOT by following up through 2013 and identified the independent predictors of myocardial infarction. The risk of myocardial infarction in the 7278 patients with HBOT was lower than in the 18,459 patients without HBOT, but this difference did not reach statistical significance [adjusted hazard ratio (AHR): 0.69; 95% confidence interval (CI) 0.45–1.07]. Stratified analyses showed that the reductions in the risk associated with HBOT for myocardial infarction reached statistical significance in male patients (AHR: 0.45; 95% CI 0.24–0.83) and during the first 2 weeks of follow-up (AHR: 0.22; 95% CI 0.05–0.96). In patients without HBOT, independent predictors of myocardial infarction were old age, male sex, and the underlying comorbidities of hypertension, diabetes, coronary artery disease, and congestive heart failure. In patients with HBOT, however, old age, male sex, and the underlying comorbidities of diabetes, coronary artery disease, and congestive heart failure were not independent predictors. HBOT was associated with a reduced risk of myocardial infarction in male patients and within 2 weeks following COP. These results may provide important reference for using HBOT in treating COP.
KeywordsCarbon monoxide Hyperbaric oxygen therapy Myocardial infarction Poisoning
Carbon monoxide poisoning
Hyperbaric oxygen therapy
Adjusted hazard ratio
National Poisoning Database
National Health Insurance Research Database
International Classification of Diseases, Ninth Revision, Clinical Modification
Human immunodeficiency virus
C-CH and H-RG designed and conceived this study and wrote the manuscript. H-CH and Y-CC performed the statistical analysis and wrote the manuscript. H-JL, C-CH, J-JW, and S-BS provided professional suggestions and wrote the manuscript. All the authors have read and approved the final manuscript.
This study was supported by Grant MOST 108-2638-B-006-001-MY2 from the Ministry of Science and Technology and Grants CMFHR10677 and CMFHR10734 from the Chi-Mei Medical Center.
Compliance with Ethical Standards
Ethical Approval and Consent to Participate
This study was conducted in strict accordance with the Declaration of Helsinki and was approved by the Institutional Review Board at the Chi-Mei Medical Center. The two databases used in this study consisted of depersonalized information, and so the informed consent was waived as the study did not affect the welfare of the participants.
- 1.Buckley, N. A., Juurlink, D. N., Isbister, G., Bennett, M. H., & Lavonas, E. J. (2011). Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Systematic Review,4, CD002041.Google Scholar
- 7.Huang, C. C., Ho, C. H., Chen, Y. C., Lin, H. J., Hsu, C. C., Wang, J. J., et al. (2017). Demographic and clinical characteristics of carbon monoxide poisoning: Nationwide data between 1999 and 2012 in Taiwan. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine,25(1), 70.CrossRefGoogle Scholar
- 17.National Health Insurance Administration, Ministry of Health and Welfare, Taiwan, R.O.C. (2014). National Health Insurance Annual Report 2014–2015.Google Scholar
- 19.Clardy, P. F., Manaker, S., Perry, H. Carbon monoxide poisoning. Retrieved July 3, 2019, from https://www.uptodate.com/contents/carbon-monoxide-poisoning#H1884832241.