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Cardiovascular Toxicology

, Volume 18, Issue 5, pp 400–406 | Cite as

Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study

  • Sule Ozbilgin
  • Derya Aslan Yurtlu
  • Beyza Küçükoztaş
  • Gonca Kamacı
  • Sezen Korkut
  • Bülent Serhan YurtluEmail author
  • M. Ensari Güneli
  • Volkan Hancı
  • Ali Günerli
Article
  • 225 Downloads

Abstract

Previous studies have shown that cyclodextrin group medicines bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to digoxin and delay the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with digoxin at 3 mg/h (0.25 mg/ml). Five minutes after the start of infusion, animals were treated with a bolus of either 16 mg/kg (Sgdx16), 100 mg/kg (Sgdx100), or 1000 mg/kg (Sgdx1000) sugammadex. The control group infusion did not contain sugammadex. Heart rate, electrocardiography, and respiratory rate were monitored. The primary endpoint was time to asystole. Digoxin infusion continued until the animals arrested. The time to asystole for the Sgdx1000 group was significantly longer compared to that for the control group (p < 0.05). The mean lethal dose of digoxin was 5.35 ± 2.06 mg/kg in the saline-treated rats. On the other hand, the mean lethal dose of digoxin was 8.54 ± 1.51 mg/kg in the sugammadex 1000 group (p < 0.05). The mean lethal dose of digoxin was significantly higher than control group (p < 0.05). We found that the 1000 mg/kg dose of sugammadex delayed digoxin cardiotoxicity in a rat model of digoxin toxicity. We conclude that further research must be conducted on the interaction between digoxin and sugammadex.

Keywords

Cyclodextrin Digoxin Toxicity Sugammadex 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Sule Ozbilgin
    • 1
  • Derya Aslan Yurtlu
    • 2
  • Beyza Küçükoztaş
    • 1
  • Gonca Kamacı
    • 3
  • Sezen Korkut
    • 4
  • Bülent Serhan Yurtlu
    • 1
    Email author
  • M. Ensari Güneli
    • 3
  • Volkan Hancı
    • 1
  • Ali Günerli
    • 1
  1. 1.Department of Anesthesiology and Reanimation, School of MedicineDokuz Eylül UniversityİzmirTurkey
  2. 2.Department of Anesthesiology and Reanimation, School of MedicineKatip Celebi UniversityİzmirTurkey
  3. 3.Department of Experimental Laboratory Animal Science, School of MedicineDokuz Eylül UniversityİzmirTurkey
  4. 4.Department of Biology, School of MedicineDokuz Eylül UniversityİzmirTurkey

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