Cardiovascular Toxicology

, Volume 11, Issue 1, pp 78–88 | Cite as

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

  • Raktim Mukherjee
  • Sudeep Banerjee
  • Niraj Joshi
  • Prem Kumar Singh
  • Darshee Baxi
  • A. V. Ramachandran


Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA (25 mg/kg bw) simultaneously. Plasma markers of cardiac damage, cardiac free radical generation, lipid peroxidation, endogenous antioxidant status, cadmium load, metallothionein induction, and histopathology were evaluated in various experimental groups. Combination of Mel + ALA significantly prevented leakage of marker enzymes of cardiac damage, changes in cardiac free radical generation, endogenous antioxidants, antioxidant status, structural alterations and augmented the degree of metallothionein (MT) induction. The results demonstrate that ML + ALA co-administration effectively protected against Cd-induced cardiac oxidative damage.


Cadmium Metallothionein Melatonin Alpha lipoic acid Cardiotoxicity 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Raktim Mukherjee
    • 1
    • 2
  • Sudeep Banerjee
    • 1
  • Niraj Joshi
    • 1
  • Prem Kumar Singh
    • 1
  • Darshee Baxi
    • 1
  • A. V. Ramachandran
    • 1
  1. 1.Division of Cardiotoxicity, Department of Zoology, Faculty of ScienceThe Maharaja Sayajirao University of BarodaVadodaraIndia
  2. 2.Shree PM Patel College of PG Studies and Research in ScienceAffiliated to SP UniversityAnandIndia

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