Advertisement

The Role of Probiotics in the Amelioration of Cadmium Toxicity

  • 32 Accesses

Abstract

Cadmium is extremely toxic heavy metal, and there is no specific, safe, and efficacious therapeutic management of cadmium toxicity. Scientific literature reveals several probiotic microorganisms which alleviate experimentally induced cadmium toxicity in animals. The present review attempts to collate the experimental studies on probiotics and probiotic-derived natural products with cadmium toxicity ameliorative effects. Literature survey revealed that seven (7) types of probiotic microorganisms exhibited significant protection from cadmium toxicity in experimental pre-clinical studies. Clinical study with significant outcome was not found in literature. From the outcomes of the pre-clinical studies, it appears that probiotics have the prospect for alleviation and treatment of cadmium toxicity.

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant unlimited access to the full article PDF.

US$ 39.95

Price includes VAT for USA

Subscribe to journal

Immediate online access to all issues from 2019. Subscription will auto renew annually.

US$ 954

This is the net price. Taxes to be calculated in checkout.

References

  1. 1.

    Bernard A (2008) Cadmium & its adverse effects on human health. Indian J Med Res 128:557–564

  2. 2.

    Zhai Q, Wang G, Zhao J, Liu X, Tian F, Zhang H, Chen W (2013) Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice. Appl Environ Microbiol 79:1508–1515

  3. 3.

    Rahimzadeh MR, Rahimzadeh MR, Kazemi S, Moghadamnia AA (2017) Cadmium toxicity and treatment: an update. Caspian J Internal Med 8:135–145

  4. 4.

    Blanusa M, Varnai VM, Piasek M, Kostial K (2005) Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem 12:2771–2794

  5. 5.

    Flora SJS, Pachauri V (2010) Chelation in metal intoxication. Int J Environ Res Public Health 7:2745–2788

  6. 6.

    Bernhoft RA (2013) Cadmium toxicity and treatment. The Scientific World 2013:394652

  7. 7.

    Bhattacharya S (2017) Medicinal plants and natural products in amelioration of arsenic toxicity: a short review. Pharm Biol 55:349–354

  8. 8.

    Bhattacharya S (2018) The role of medicinal plants and natural products in melioration of cadmium toxicity. Orient Pharm Exp Med 18:177–186

  9. 9.

    Bhattacharya S (2018) Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity. Interdiscip Toxicol 11:247–254

  10. 10.

    Foligné B, Daniel C, Pot B (2013) Probiotics from research to market: the possibilities, risks and challenges. Curr Opin Microbiol 16:284–292

  11. 11.

    Jankovic I, Sybesma W, Phothirath P, Ananta E, Mercenier A (2010) Application of probiotics in food products-challenges and new approaches. Curr Opin Biotechnol 21:175–181

  12. 12.

    Rijkers GT, Bengmark S, Enck P, Haller D, Herz U, Kalliomaki M, Kudo S, Lenoir-Wijnkoop I, Mercenier A, Myllyluoma E (2010) Guidance for substantiating the evidence for beneficial effects of probiotics: current status and recommendations for future research. J Nutr 140:671S–676S

  13. 13.

    Feng P, Kakade A, Virk AK, Li X, Liu P (2019) A review on gut remediation of selected environmental contaminants: possible roles of probiotics and gut microbiota. Nutrients 11:22

  14. 14.

    Zhai Q, Wang G, Zhao J, Liu X, Narbad A, Chen YQ, Zhang H, Tian F, Chen W (2014) Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice: intestinal sequestration is not the only route of protection. Appl Environ Microbiol 80:4063–4071

  15. 15.

    Zhai Q, Yin Y, Yu L, Wang G, Tian F, Yu R, Zhao J, Liu X, Chen YQ, Zhang H, Chen W (2015) Screening of lactic acid bacteria with potential protective effects against cadmium toxicity. Food Control 54:232–230

  16. 16.

    Gerbino E, Carasi P, Tymczyszyn EE, Gómez-Zavaglia A (2014) Removal of cadmium by Lactobacillus kefir as a protective tool against toxicity. J Dairy Res 81:280–287

  17. 17.

    Jama AM, Mitic-Culafic D, Kolarevic S, Ðuraševic SF, Kneževic-Vukcevic J (2012) Protective effect of probiotic bacteria against cadmium-induced genotoxicity in rat hepatocytes in vivo and in vitro. Arch Biol Sci 64:1197–1206

  18. 18.

    Djurasevic S, Jama A, Jasnic N, Vujovic P, Jovanovic M, Mitic-Culafic D, Knezevic-Vukcevic J, Cakic-Milosevic M, Ilijevic K, Djordjevic J (2017) The protective effects of probiotic bacteria on cadmium toxicity in rats. J Med Food 20:189–196

  19. 19.

    Raghuvanshi R, Chaudhari A, Kumar GN (2016) Amelioration of cadmium- and mercury-induced liver and kidney damage in rats by genetically engineered probiotic Escherichia coli Nissle 1917 producing pyrroloquinoline quinone with oral supplementation of citric acid. Nutrition 32:1285–1294

  20. 20.

    Song S, Oh S, Lim K (2016) Lactobacillus plantarum L67 glycoprotein protects against cadmium chloride toxicity in RAW 264.7 cells. J Dairy Sci 99:1812–1821

  21. 21.

    Zhai Q, Tian F, Zhao J, Zhang H, Narbad A, Chen W (2016) Oral administration of probiotics inhibits absorption of the heavy metal cadmium by protecting the intestinal barrier. Appl Environ Microbiol 82:4429–4440

  22. 22.

    Abd-El-Moneim OM, Abd El-Kader HAM, El-Rahim AHA, Radwan HA, Fadel M, Farag IM (2017) Modulatory role of Saccharomyces cerevisiae against cadmium-induced genotoxicity in mice. J Arab Soc Med Res 12:27–38

  23. 23.

    Kumar N, Kumar V, Panwar R, Ram C (2017) Efficacy of indigenous probiotic Lactobacillus strains to reduce cadmium bioaccessibility - an in vitro digestion model. Environ Sci Pollut Res Int 24:1241–1250

  24. 24.

    Jafarpour D, Shekarforoush SS, Ghaisar HR, Nazifi S, Sajedianfard J, Eskandari MH (2017) Protective effects of synbiotic diets of Bacillus coagulans, Lactobacillus plantarum and inulin against acute cadmium toxicity in rats. BMC Complement Altern Med 17:291

  25. 25.

    Zhai Q, Yu L, Li T, Zhu J, Zhang C, Zhao J, Zhang H, Chen W (2017) Effect of dietary probiotic supplementation on intestinal microbiota and physiological conditions of Nile tilapia (Oreochromis niloticus) under waterborne cadmium exposure. Antonie Van Leeuwenhoek 110:501–513

  26. 26.

    Kadry MO, Megeed RA (2018) Probiotics as a complementary therapy in the model of cadmium chloride toxicity: crosstalk of β-catenin, BDNF, and StAR signaling pathways. Biol Trace Elem Res 185:404–413

  27. 27.

    Allam NG, Ali EMM, Shabanna S, Abd-Elrahman E (2018) Protective efficacy of Streptococcus thermophilus against acute cadmium toxicity in mice. Iranian J Pharm Res 17:695–707

  28. 28.

    Daisley BA, Monachese M, Trinder M, Bisanz JE, Chmiel JA, Burton JP, Reid G (2019) Immobilization of cadmium and lead by Lactobacillus rhamnosus GR-1 mitigates apical-to-basolateral heavy metal translocation in a Caco-2 model of the intestinal epithelium. Gut Microbes 10:321–333

  29. 29.

    Dubey V, Mishra AK, Ghosh AR, Mandal BK (2019) Probiotic Pediococcus pentosaceus GS4 shields brush border membrane and alleviates liver toxicity imposed by chronic cadmium exposure in Swiss albino mice. J Appl Microbiol 126:1233–1244

  30. 30.

    Monachese M, Burton JP, Reid G (2012) Bioremediation and tolerance of humans to heavy metals through microbial processes: a potential role for probiotics? Appl Environ Microbiol 78:6397–6404

  31. 31.

    Tinkov AA, Gritsenko VA, Skalnaya MG, Cherkasov SV, Aaseth J, Skalny AV (2018) Gut as a target for cadmium toxicity. Environ Pollut 235:429–434

  32. 32.

    Halttunen T, Kankaanpää P, Tahvonen R, Salminen S, Ouwehand AC (2003) Cadmium removal by lactic acid bacteria. Bioscience & Microflora 22:93–97

  33. 33.

    Halttunen T, Salminen S, Tahvonen R (2007) Rapid removal of lead and cadmium from water by specific lactic acid bacteria. Int J Food Microbiol 114:30–35

  34. 34.

    Halttunen T, Collado M, El-Nezami H, Meriluoto J, Salminen S (2008) Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution. Lett Appl Microbiol 46:160–165

  35. 35.

    Patel A, Aparna SV, Shah N, Verma DK (2017) Lactic acid bacteria as metal quenchers to improve food safety and quality. AgroLife Scientific J 6:146–154

  36. 36.

    Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ, Nawrot T, Vangronsveld J, Smeets K (2010) Cadmium stress: an oxidative challenge. Biometals 23:927–940

  37. 37.

    Patra RC, Rautray AK, Swarup D (2011) Oxidative stress in lead and cadmium toxicity and its amelioration. Vet Med Int 2011:457327

  38. 38.

    Das A, Roy A, Das R, Bhattacharya S, Haldar PK (2016) Naringenin alleviates cadmium-induced toxicity through the abrogation of oxidative stress in Swiss albino mice. J Environ Pathol Toxicol Oncol 35:161–169

  39. 39.

    Kullisaar T, Songisepp E, Mikelsaar M, Zilmer K, Vihalemm T, Zilmer M (2003) Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human subjects. Brit J Nutr 90:449–456

  40. 40.

    Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V (2012) Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 28:539–543

  41. 41.

    Wang Y, Wu Y, Wang Y, Xu H, Mei X, Yu D, Wang Y, Li W (2017) Antioxidant properties of probiotic bacteria. Nutrients 9:521

  42. 42.

    Zhai Q, Xiao Y, Zhao J, Tian F, Zhang H, Narbad A, Chen W (2017b) Identification of key proteins and pathways in cadmium tolerance of Lactobacillus plantarum strains by proteomic analysis. Sci Rep 7:1182

  43. 43.

    Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G (2014) Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children. mBio 5:e01580–e01514

  44. 44.

    Astolfi ML, Protano C, Schiavi E, Marconi E, Capobianco D, Massimi L, Ristorini M, Baldassarre ME, Laforgia N, Vitali M, Canepari S, Mastromarino P (2019) A prophylactic multi-strain probiotic treatment to reduce the absorption of toxic elements: in-vitro study and biomonitoring of breast milk and infant stools. Environ Int 130:104818

Download references

Author information

Correspondence to Sanjib Bhattacharya.

Ethics declarations

Conflict of Interest

The author declares that he has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the author.

Informed Consent

Informed consent is not applicable in this study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bhattacharya, S. The Role of Probiotics in the Amelioration of Cadmium Toxicity. Biol Trace Elem Res (2020). https://doi.org/10.1007/s12011-020-02025-x

Download citation

Keywords

  • Probiotics
  • Cadmium
  • Lactobacilli
  • Oxidative stress