Dietary Intake of Cadmium, Chromium, Copper, Nickel, and Lead through the Consumption of Meat, Liver, and Kidney and Assessment of Human Health Risk in Birjand, Southeast of Iran
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This study aimed to evaluate the mean concentration of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), and lead (Pb) in the meat and offal of cow and sheep. Also, the estimated daily intake (EDI) and health risk of these metals were calculated. Analysis of metals was undertaken by the use of an inductively coupled plasma-optic emission spectroscopy (ICP-OES). All samples were contaminated with all metals. Principal component analysis (PCA) showed a clear differentiation of cow and sheep in both the kidney and liver samples. In the liver and kidney, level of Cd, Cu, and Pb were positively correlated. The highest target hazard quotients (THQs) were calculated for Pb. Cd level in cow kidney had the highest carcinogenic rate (CR). Although, hazard index (HI) was lower than one, consumption of muscle especially in children should be noticed in both national and international consumers due to higher level of HI.
KeywordsMeat Kidney Liver Estimated daily intake Target hazard quotient Carcinogenic rate
TZ and KN contributed in the conception and design of the study. FS performed the statistical analysis and drafting of the manuscript. TZ conducted the experiments and wrote the manuscript. All authors approved the final version of the manuscript.
The authors acknowledge the research and technology deputy of Birjand University of Medical Sciences for support of this study (grant No 4273).
Compliance with Ethical Standards
This study was carried out according to the international ethical guidelines and approved by the ethical committee of Birjand University of Medical Sciences.
Conflict of Interest
The authors declare that they have no competing interest.
- 1.Bortey-Sam N, Nakayama SMM, Ikenaka Y, Akoto O, Baidoo E, Yohannes YB, Mizukawa H, Ishizuka M (2015) Human health risks from metals and metalloid via consumption of food animals near gold mines in Tarkwa, Ghana: estimation of the daily intakes and target hazard quotients (THQs). Ecotoxicol Environ Saf 111:160–167CrossRefGoogle Scholar
- 2.Harmanescu M, Alda LM, Bordean DM, Gogoasa I, Gergen I (2011) Heavy metals health risk assessment for population via consumption of vegetables grown in old mining area; a case study: Banat County, Romania. Chem cent 5(64):10Google Scholar
- 8.Ambushe AA, Hlongwane MM, McCrindle RI, McCrindle CME (2012) Assessment of levels of V, Cr, Mn, Sr, Cd, Pb and U in bovine meat. S Afr J Chem 65:159–164Google Scholar
- 10.Shahryari T, Moashery BN, Sharifzadeh GR (2011) Concentrations of chromium and copper in the ground water and drinking water distribution network of Birjand, 2009-2010. J Birj uni med 17(4):62–67Google Scholar
- 13.European Food Safety Authority (EFSA) (2009) Scientific opinion of the panel on contaminants in the food chain on a request from the European Commission on cadmium in food. EFSA J 980:1–139Google Scholar
- 14.European Commission (2006) COMMISSION REGULATION (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. OffJEurUnion L 364, 20.12.2006,:p. 5Google Scholar
- 15.JECFA (2009) Evaluations of the Joint FAO/WHO Expert Committee on Food Additives. <http://apps.who.int/food-additives-contaminants-jecfa-database/PrintPreview.aspx?chemID=5879>
- 19.Wikipedia (2018) South Khorasan Province. <https://en.wikipedia.org/wiki/South_Khorasan_Province>
- 20.US EPA (2010) Risk-based concentration table. <http://www.epa.gov/reg3hwmd/risk/human/index.htm>
- 21.ISIRI (2010) Food & feed-maximum limit of heavy metals. ISIRI 12968, 1st edn. Institute of Standards and Industrial Research of Iran, TehranGoogle Scholar
- 22.US EPA (2007) Integrated Risk Information System-Database (IRIS). Philadelphia PA;. <https://www.epa.gov/iris>
- 25.US EPA (2000) Risk-based concentration table,. <https://www.epa.gov/iris>
- 27.Pompe-Gotal J, Crnic AP (2002) Cadmium in tissue of roe deer (Capreolus capreolus) in Croatia. VetArhiv 72:303–310Google Scholar
- 28.Agency for Toxic Substances and Disease Registry (ATSDR) (2004) U.S. Department of Health and Human Services. Atlanta, GA: Public Health Service. Toxicological profile for copper <http://www.atsdr.cdc.gov/toxprofiles/>
- 30.JECFA (2000) Evaluation of certain food additives and contaminants. Report of the Fifty-Third of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series No.896. GenevaGoogle Scholar
- 31.Abou-Arab AAK (2001) Heavy metal contents in Egyptian meat and the role of detergent washing on their levels. Food and chemical toxicology 39 (6):593–599Google Scholar
- 33.Darwish WS, Hussein MA, El-Desoky K, Ikenaka Y, Nakayama S, Mizukawa HA, Ishizuka M (2015) Incidence and public health risk assessment of toxic metal residues (cadmium and lead) in Egyptian cattle and sheep meat. Int Food Res J 22(4):1719–1726Google Scholar
- 35.European Environment and Health Information System (EEHIS) (2007) Exposure of children to chemical hazards in food. Fact Sheet No.4.4,CODE:RPG4_Food_EX1Google Scholar