Trace Elements in the Lung Tissue Affected by Sarcoidosis
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In the lungs of 76 patients with verified sarcoidosis, 28 chemical elements were identified with neutron activation analysis. High levels of Ca, Fe, Cr, Co, Cs, Eu, Lu, Th, Hf, Au, and U and low level of Na compared to the control samples were determined in sarcoidosis. There were no significant differences in the content of Zn, Rb, La, Sm, Sr, Nd, As, Br, Ag, Tb, Sc, Ta, Sb, Ba, and Yb. Spearman correlation analysis shows multiple positive associations, with the maximum being in pairs as follows: Fe-Cr, Eu-La, Ce-Lu, Hf-Cr, Sc-Zn, Fe-Hf, Ce-Co, and Sb-Cr. These studies support the hypothesis that sarcoidosis is a response of the organism in the form of granulomatous inflammation when exposed to heavy metals and rare earth elements in the environment. We assume that the role of calcium and iron is to separate granulomas from the tissues of the body.
KeywordsSarcoidosis Trace elements Environment Lungs
Сompliance with Ethical Standards
The study was conducted in compliance with ethical standards.
Conflict of Interest
There authors declare that they have no conflict of interest.
The study was approved by the local ethical committee of the Siberian State Medical University. Registration number of approval is 5045 of 28.11.2016.
Informed consent was obtained from all individual participants included in the study.
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