Advertisement

Trace Elements in the Lung Tissue Affected by Sarcoidosis

  • Olga DenisovaEmail author
  • George Chernogoryuk
  • Natalya Baranovskaya
  • Leonid Rikhvanov
  • Nikolaj Shefer
  • Galina Chernjavskaya
  • Inna Palchikova
  • Tatyana Kalacheva
Article
  • 12 Downloads

Abstract

In the lungs of 76 patients with verified sarcoidosis, 28 chemical elements were identified with neutron activation analysis. High levels of Ca, Fe, Cr, Co, Cs, Eu, Lu, Th, Hf, Au, and U and low level of Na compared to the control samples were determined in sarcoidosis. There were no significant differences in the content of Zn, Rb, La, Sm, Sr, Nd, As, Br, Ag, Tb, Sc, Ta, Sb, Ba, and Yb. Spearman correlation analysis shows multiple positive associations, with the maximum being in pairs as follows: Fe-Cr, Eu-La, Ce-Lu, Hf-Cr, Sc-Zn, Fe-Hf, Ce-Co, and Sb-Cr. These studies support the hypothesis that sarcoidosis is a response of the organism in the form of granulomatous inflammation when exposed to heavy metals and rare earth elements in the environment. We assume that the role of calcium and iron is to separate granulomas from the tissues of the body.

Keywords

Sarcoidosis Trace elements Environment Lungs 

Notes

Сompliance with Ethical Standards

The study was conducted in compliance with ethical standards.

Conflict of Interest

There authors declare that they have no conflict of interest.

The study was approved by the local ethical committee of the Siberian State Medical University. Registration number of approval is 5045 of 28.11.2016.

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Baughman RP (2007) Sarcoidosis. Clin Dermatol 25(3):231CrossRefGoogle Scholar
  2. 2.
    Baughman RP, Culver DA, Judson MA (2011) A concise review of pulmonary sarcoidosis. Respir Crit Care Med 183(5):573–581CrossRefGoogle Scholar
  3. 3.
    Celada LJ, Hawkins C, Drake WP (2015) The etiologic role of infectious antigens in sarcoidosis pathogenesis. Clin Chest Med 36:561–568CrossRefGoogle Scholar
  4. 4.
    Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Thompson BW, Teirstein AS, Yeager H Jr, Johns CJ, Rabin DL, Rybicki BA, Cherniack R, ACCESS Research Group (2004) A case control etiologic study of sarcoidosis: environmental and occupational risk factors. J Respir Crit Care Med 170:1324–1330CrossRefGoogle Scholar
  5. 5.
    Dai J, Huang M, Cao M, Miao L, Xiao Y, Shi Y, Meng F, Cai H (2014) Giant cell interstitial pneumonia: unusual lung disorder and an update. Chin Med J 127:2819–2823PubMedGoogle Scholar
  6. 6.
    Ding B, Ding L, Yu B, Fan C, Han L, Hu J, Zhu B (2015) Analysis of 2 patients with occupational hard mental lung disease. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 33(1):45–48PubMedGoogle Scholar
  7. 7.
    Corradi M, Acampa O, Goldoni M, Adami E, Apostoli P, de Palma G, Pesci A, Mutti A (2009) Metallic elements in exhaled breath condensate of patients with interstitial lung diseases. J Breath Res 3:046003.  https://doi.org/10.1088/1752-7155/3/4/046003 CrossRefPubMedGoogle Scholar
  8. 8.
    Bargagli E, Monaci F, Bianchi N, Bucci C, Rottoli P (2008) Analysis of trace elements in bronchoalveolar lavage of patients with diffuse lung diseases. Biol Trace Elem Res 124:225–235CrossRefGoogle Scholar
  9. 9.
    Maier LA (2002) Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseases. J Thorac Imaging 17:273–284CrossRefGoogle Scholar
  10. 10.
    Balmes JR, Abraham JL, Dweik RA, Fireman E, Fontenot AP, Maier LA, Muller-Quernheim J, Ostiguy G, Pepper LD, Saltini C, Schuler CR, Takaro TK, Wambach PF, ATS Ad Hoc Committee on Beryllium Sensitivity and Chronic Beryllium Disease (2014) An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med 190:34–59CrossRefGoogle Scholar
  11. 11.
    Cai HR, Cao M, Meng FQ, Wei JY (2007) Pulmonary sarcoid-like granulomatosis induced by aluminum dust: report of a case and literature review. Chin Med J 120:1556–1560CrossRefGoogle Scholar
  12. 12.
    Pryce DW, King CM (1990) Orofacial granulomatosis associated with delayed hypersensitivity to cobalt. Clin Exp Dermatol 15:384–386CrossRefGoogle Scholar
  13. 13.
    Hahtola PA, Järvenpää RE, Lounatmaa K, Mattila JJ, Rantala I, Uitti JA, Sutinen S (2000) Hard metal alveolitis accompanied by rheumatoid arthritis. Respiration 67(2):209–212CrossRefGoogle Scholar
  14. 14.
    Denisova OA, Egorova KK, Chernogoryuk GE, Baranovskaya NV, Rihvanov LP, Cherniavsky GM, Goloschapova AN (2013) Features of microelement composition in blood of patients with sarcoidosis. Prakticheskaja medicina 74:72–74Google Scholar
  15. 15.
    Denisova OA, Chernogoryuk GE, Baranovskaya NV, Rikhvanov LP, Chernyavskaya GM (2017) Macroelement and microelement composition of mediastinal lymph nodes of patients with sarcoidosis. Russian Pulmonology 27(6):754–759. (In Russ.).  https://doi.org/10.18093/0869-0189-2017-27-6-754-759 CrossRefGoogle Scholar
  16. 16.
    Takemoto K, Kawai H, Kuwahara T, Nishina M, Adachi S (1991) Metal concentrations in human lung tissue, with special reference to age, sex, cause of death, emphysema and contamination of lung tissue. Int Arch Occup Environ Health 62(8):579–586CrossRefGoogle Scholar
  17. 17.
    Morton J, Tan E, Suvarna SK (2017) Multi-elemental analysis of human lung samples using inductively coupled plasma mass spectrometry. J Trace Elem Med Biol Sep 43:63–71.  https://doi.org/10.1016/j.jtemb.2016.11.008 CrossRefGoogle Scholar
  18. 18.
    Baranovskaya NB, Rikhvanov LP, Ignatova TA, Narkovich DV, Denisova OA (2015) The human geochemistry essays: a monograph. Deltaplan, TomskGoogle Scholar
  19. 19.
    Jazikov EG, Talovskaja AV, Zhornjak LV (2010) Assessment of environmental and geochemical condition of Tomsk territory according to analysis of soils and dust aerosols: a monograph. Izdatelstvo TPU, TomskGoogle Scholar
  20. 20.
    Denisova OA, Chernogoryuk GE, Egorova KK, Baranovskaya NV, Rikhvanov LP, Chernjavskaya GM (2016) Role of geoecological factors in the sarcoidosis incidence formation in Tomsk and its region. Healthcare of the Russian Federation 60:147–151CrossRefGoogle Scholar
  21. 21.
    Huang YT, Ghio J, Nozik-Grayck E, Piantadosi CA (2001) Vascular release of nonheme iron in perfused rabbit lungs. Am J Phys Lung Cell Mol Phys 280:474–481.  https://doi.org/10.1152/ajplung.2001.280.3.L474 CrossRefGoogle Scholar
  22. 22.
    Ghio AJ, Pavlisko EN, Roggli VL (2015) Iron and iron-related proteins in asbestosis. J Environ Pathol Toxicol Oncol 34(4):277–285CrossRefGoogle Scholar
  23. 23.
    Conron M, Young C, Beynon HL (2000) Calcium metabolism in sarcoidosis and its clinical implications. Rheumatology (Oxford) 39:707–713CrossRefGoogle Scholar
  24. 24.
    Adams JS, Singer FR, Gacad MA, Sharma OP, Hayes MJ, Vouros P, Holick MF (1985) Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab 60:960–966CrossRefGoogle Scholar
  25. 25.
    Ghio AJ, Roggli VL, Kennedy TP, Piantadosi CA (2000) Calcium oxalate and iron accumulation in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 17:140–150PubMedGoogle Scholar
  26. 26.
    Falk S, Kratzsch J, Paschke R, Koch CA (2007) Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D. Med Sci Monit 13(11):133–136Google Scholar
  27. 27.
    Mohan N, Akter R, Bryant K (2016) Exhaled breath markers of alveolar macrophage activity in sarcoidosis. Inflamm Res 65(6):471–478.  https://doi.org/10.1007/s00011-016-0929-y CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Hospital Therapy DepartmentSiberian State Medical UniversityTomskRussia
  2. 2.Division for Geology of the School of Earth Sciences and EngineeringTomsk Polytechnic UniversityTomskRussia
  3. 3.Surgery department, Tomsk Regional Oncologic DispensaryTomskRussia
  4. 4.Department of Internal MedicineTomsk Regional Clinical HospitalTomskRussia
  5. 5.Department of General Practice and Polyclinic TherapySiberian State Medical UniversityTomskRussia

Personalised recommendations