Fifty male mice were exposed to 50 nm unmodified nano-ZnO through intragastric administration for 90 days to detect the long-term effects of unmodified nano-ZnO in mice. Results showed that the blood glucose, serum follicle stimulating hormone, luteinizing hormone, testosterone, and estradiol were significantly decreased (p < 0.05). The serum triglyceride, total cholesterol, and low-density lipoprotein were significantly increased (p < 0.05). The semen quality of the 160 mg/kg·bw group were significantly lowered (p < 0.05). The liver and testis catalase and CuZn-SOD activities were significantly elevated (p < 0.05). The abilities of •OH inhibition in the livers and testes of the 160 mg/kg·bw group were significantly lowered (p < 0.05). The liver and testis MDA levels of the 160 mg/kg·bw group were significantly elevated (p < 0.05). Results indicate that exposure of nano-ZnO could induce lipid metabolism disorder, hyperlipidemia, and reproductive toxicity to male mice through oxidative injury.
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This work was supported by the National Natural Science Foundation of China (Nos. 31402263, 31872537, 41301562), the National Natural Science Foundation of Henan province (No. 182300410087), and the Key Scientific and Technological Project of Henan province (No. 182102110257).
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The original version of this article was revised: The correct title should be “The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice”.
• Nano-ZnO could induce lipid metabolism disorder and reproductive toxicity.
• Nano-ZnO showed adverse effects on semen quality and spermatogenesis.
• The lipid metabolism disorder and reproductive toxicity induced by nano-ZnO might be through oxidative stress.
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Kong, T., Zhang, S., Zhang, C. et al. The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice. Biol Trace Elem Res 194, 432–442 (2020). https://doi.org/10.1007/s12011-019-01792-6
- Nano-meter zinc oxide
- Lipid metabolism
- Semen quality