Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis

  • Wangqing Chen
  • Xingchen ZhouEmail author
  • Wu ZhuEmail author


Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls. The people with psoriasis showed a higher level of zinc in lesion tissue (standard mean difference (SMD) = 14.43; 95% confidence interval (CI), 7.89–20.97; P < 0.0001), and a higher level of serum copper than controls (SMD = 18.23; 95% CI, 5.06–31.40; P = 0.007). Our findings indicated that the trace element of copper and zinc levels are in a homeostatic imbalance in psoriasis patients when compared with controls, which raise the question whether this imbalance can be taken as the therapy target for psoriasis.


Psoriasis Trace elements Zinc Copper Iron Selenium 


Author Contributions

The eligibility of the studies for meta-analysis was evaluated by Wangqing Chen and Wu Zhu, the discrepancy was discussed with Xingchen Zhou, and the manuscript was written by Wangqing Chen and Xingchen Zhou.


This work was supported by grants from the Natural Science Foundation of China (No. 81773329), the Natural Science Youth Foundation of China (NO. 81803118).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

12011_2018_1626_MOESM1_ESM.png (25 kb)
Figure S1 The serum zinc levels in male and female psoriasis patients (PNG 25 kb)
12011_2018_1626_MOESM2_ESM.png (26 kb)
Figure S2 The serum zinc levels in mild and severe psoriasis patients (PNG 26 kb)
12011_2018_1626_MOESM3_ESM.png (20 kb)
Figure S3 The serum copper levels in male and female psoriasis patients (PNG 20 kb)
12011_2018_1626_MOESM4_ESM.png (21 kb)
Figure S4 The serum copper levels in mild and severe psoriasis patients (PNG 20 kb)
12011_2018_1626_MOESM5_ESM.png (20 kb)
Figure S5 The serum iron levels in mild and severe psoriasis patients (PNG 20 kb)
12011_2018_1626_MOESM6_ESM.png (22 kb)
Figure S6 The serum selenium levels in male and female psoriasis patients (PNG 21 kb)
12011_2018_1626_MOESM7_ESM.png (20 kb)
Figure S7 The serum selenium levels in mild and severe psoriasis patients (PNG 19 kb)


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Authors and Affiliations

  1. 1.Department of Clinical Pharmacology, Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Department of Pharmacy, Xiangya HospitalCentral South UniversityChangshaChina
  3. 3.Department of Dermatology, Xiangya HospitalCentral South UniversityChangshaChina

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