Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis
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Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls. The people with psoriasis showed a higher level of zinc in lesion tissue (standard mean difference (SMD) = 14.43; 95% confidence interval (CI), 7.89–20.97; P < 0.0001), and a higher level of serum copper than controls (SMD = 18.23; 95% CI, 5.06–31.40; P = 0.007). Our findings indicated that the trace element of copper and zinc levels are in a homeostatic imbalance in psoriasis patients when compared with controls, which raise the question whether this imbalance can be taken as the therapy target for psoriasis.
KeywordsPsoriasis Trace elements Zinc Copper Iron Selenium
The eligibility of the studies for meta-analysis was evaluated by Wangqing Chen and Wu Zhu, the discrepancy was discussed with Xingchen Zhou, and the manuscript was written by Wangqing Chen and Xingchen Zhou.
This work was supported by grants from the Natural Science Foundation of China (No. 81773329), the Natural Science Youth Foundation of China (NO. 81803118).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 1.Wacewicz M, Socha K, Soroczynska J, Niczyporuk M, Aleksiejczuk P, Ostrowska J, Borawska MH (2017) Concentration of selenium, zinc, copper, Cu/Zn ratio, Total antioxidant status and C-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: a case-control study. J Trace Elem Med Biol 44:109–114CrossRefGoogle Scholar
- 5.Liu P, He Y, Wang H, Kuang Y, Chen W, Li J, Chen M, Zhang J, Su J, Zhao S, Chen M, Tao J, Chen X, Zhu W (2017) The expression of Mctla-4 in skin lesion inversely correlates with the severity of psoriasis. J Dermatol Sci 89(3):233–240Google Scholar
- 15.Saghazadeh A, Mahmoudi M, Dehghani Ashkezari A, Oliaie Rezaie N, Rezaei N (2017) Systematic review and meta-analysis shows a specific micronutrient profile in people with down syndrome: lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium. PLoS One 12:e0175437CrossRefGoogle Scholar
- 24.Oztürk G, Erba D, Gelir E, Gülekon A, Imir T (2001) “Natural killer cell activity, serum immunoglobulins, complement proteins, and zinc levels in patients with psoriasis vulgaris.” clinical trial; controlled clinical trial; research support, non-U.S. Gov’t. Immunol Investig 30(3):181–190. http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/979/CN-00373979/frame.html. Accessed 31 Jan 2003CrossRefGoogle Scholar
- 27.Bimola Devi C, Jibankumar Singh S, Nandakishore T, Sunil Singh S, Rupachandra Singh L, Kunjeshwori Devi S (2011) Variation of serum zinc level in psoriasis. J Med Soc 25:38–41Google Scholar
- 28.Shahidi-Dadras M, Namazi N, Khalilazar S, Younespour S (2012) Trace elements status in psoriasis and their relationship with the severity of the disease. Iran J Dermatol 15:38–41Google Scholar
- 32.Wang G, Yu X, Xiao J (2004) The serum zinc levels in child psoriasis vulgaris. Clin J Dermatol Venerol Integ Trad W Med 3:144–146Google Scholar
- 33.Yan Z (2004) Dynamic observation of microelement Cu: Zn ratio in psoriasis vivo. J Huaihai Med 22:365–366Google Scholar
- 34.Cui J, Cui R, Zhang X, Xu H, Feng J (2005) The detection of the serum microelement in psoriatic patients. Chin J Lepr Skin Dis 21:617–619Google Scholar
- 40.Narang APS, Kumar B, Kaur IJ (1994) Serum zinc and copper levels in psoriasis. Trace Elem Med 11:36–37Google Scholar
- 62.Sirmali M, Uz E, Sirmali R, Kilbas A, Yilmaz HR, Altuntas I, Naziroglu M, Delibas N, Vural H (2007) Protective effects of erdosteine and vitamins C and E combination on ischemia-reperfusion-induced lung oxidative stress and plasma copper and zinc levels in a rat hind limb model. Biol Trace Elem Res 118:43–52CrossRefGoogle Scholar
- 72.Seneczko F, Kostusiak MM, Kaszuba A (1995) Blood serum concentrations of sodium, potassium, magnesium, and calcium ion, and total calcium in patients with psoriasis vulgaris treated with Puva and Anthraline. Przegl Dermatol 82:513–520Google Scholar
- 74.Toossi P, Sadat Amini SH, Sadat Amini MS, Partovi Kia M, Enamzade R, Kazeminejad A, Esmaeily Radvar S, Younespour S (2015) Assessment of serum levels of osteopontin, selenium and prolactin in patients with psoriasis compared with healthy controls, and their association with psoriasis severity. Clin Exp Dermatol 40:741–746CrossRefGoogle Scholar