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Trace Elements Associated with Systemic Lupus Erythematosus and Insulin Resistance

  • Eliel Marcio Pedro
  • Lorena Flor da Rosa Franchi Santos
  • Bruna Miglioranza Scavuzzi
  • Tatiana Mayumi Veiga Iriyoda
  • Tiago Severo Peixe
  • Marcell Alysson Batiste Lozovoy
  • Edna Maria Vissoci Reiche
  • Isaias Dichi
  • Andréa Name Colado SimãoEmail author
  • Maria Josefa Santos
Article
  • 34 Downloads

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The current study aimed to assess the relationship between serum concentration of lithium (Li), vanadium (V), copper (Cu), zinc (Zn), molybdenum (Mo), cadmium (Cd), and lead (Pb) and SLE diagnosis, disease activity measured by SLE disease activity index (SLEDAI) and insulin resistance (IR). This case-control, cross-sectional study included 225 patients, 120 healthy controls, and 105 SLE patients. Serum concentration of Li, V, Cu, Zn, Mo, Cd, and Pb was measured. Serum concentrations of V (p < 0.001), Zn (p < 0.001), and Pb (p < 0.001) were lower and Mo (p < 0.001) and Li (p < 0.001) were higher in patients with SLE compared to healthy controls. SLE diagnosis was associated with higher serum Li (p < 0.001) concentration and lower V (p < 0.001), Zn (p = 0.003), and Pb (p = 0.020). Toxic metals and trace elements were not associated with disease activity. Levels of Cd were higher in patients with IR (p = 0.042). There was no significant association between IR and the other metals. The results indicate that SLE patients have different profiles of trace elements and toxic metals compared to healthy controls. While some toxic metals and trace elements were found to be associated with SLE diagnosis, they had no effect on disease activity and IR.

Keywords

SLE disease activity index (SLEDAI) Heavy metals Trace elements Insulin resistance Glucose homeostasis 

Notes

Funding Information

This study was supported by Laboratory of Atomic Emission Spectrometry (LAES) from State University of Londrina- Parana State, Brazil.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Eliel Marcio Pedro
    • 1
  • Lorena Flor da Rosa Franchi Santos
    • 2
  • Bruna Miglioranza Scavuzzi
    • 2
  • Tatiana Mayumi Veiga Iriyoda
    • 3
  • Tiago Severo Peixe
    • 4
  • Marcell Alysson Batiste Lozovoy
    • 4
  • Edna Maria Vissoci Reiche
    • 4
  • Isaias Dichi
    • 5
  • Andréa Name Colado Simão
    • 3
    • 4
    Email author
  • Maria Josefa Santos
    • 4
  1. 1.Department of ChemistryUniversity of LondrinaLondrinaBrazil
  2. 2.Research Laboratory of Applied ImmunologyUniversity of LondrinaParanáBrazil
  3. 3.Department of RheumatologyPontifícia Universidade Católica, PUCLondrinaBrazil
  4. 4.Department of Pathology, Clinical Analysis and ToxicologyUniversity of LondrinaLondrinaBrazil
  5. 5.Department of Internal MedicineUniversity of LondrinaLondrinaBrazil

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