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Biological Trace Element Research

, Volume 188, Issue 1, pp 140–147 | Cite as

Investigating the Essentiality and Requirements of Iron from the Ancient to the Present

  • Katsuhiko YokoiEmail author
Article
  • 18 Downloads

Abstract

This review discusses the development of studies that evaluated the essentiality and requirements of iron from the ancient to the present. The therapeutic effects of iron compounds were recognized by the ancient Greeks and Romans. The earliest recognition of the essentiality of iron was stated by Paracelsus, a distinguished physician alchemist, in the sixteenth century. Iron was included in the earliest nutritional standard prepared for the Royal Army by E. A. Parkes, the first professor of hygiene. The League of Nations Health Organisation determined average iron requirements based on literature review. In the first US Recommended Dietary Allowances (RDA), the RDA of iron was determined from the results of iron balance studies. In the current Dietary Reference Intakes, iron requirements were determined based on the factorial method with the aid of Monte Carlo simulation for combining basal and menstrual iron losses. Population data analysis is a recently developed alternative that does not use the pre-estimated iron absorption rate and requires the prevalence of inadequacy instead. Population data analysis uses the convolution integral for combining basal and menstrual iron losses to ensure the required accuracy. This review also provides new estimates of hair and nail iron losses.

Keywords

Iron requirement Balance study Factorial method Population data analysis Menstrual iron loss Convolution integral 

Notes

Funding

This work was partly supported by the Japan Society for the Promotion of Science KAKENHI for Scientific Research (C) (grant no. 17K00877).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Pliny the Elder (1961) Book 34, chapter 45–55. In: Rackham H (translated and ed) Natural history. Harvard University Press, Cambridge, MA, pp 236–241Google Scholar
  2. 2.
    Paracelsus (1616) Von den Naturlichen Wassern. Das vierdte Buch. In: Philosophi und Medici opera, Bucher und Schrifften. Lazari Zetzners Seligen Erben, Strassburg, pp 147–157. https://archive.org/details/aureoliphilippit00para. Accessed 30 July 2018
  3. 3.
    Yokoi K, Konomi A (2017) Iron deficiency without anaemia is a potential cause of fatigue: meta-analyses of randomised controlled trials and cross-sectional studies. Br J Nutr 117:1422–1431CrossRefGoogle Scholar
  4. 4.
    von Liebig J (1842) Animal chemistry, or chemistry in its application to physiology and pathology, first edn. Taylor and Walton, LondonGoogle Scholar
  5. 5.
    Liebig J (1842) The theory of respiration. Prov Med J Retrosp Med Sci 4:477–480Google Scholar
  6. 6.
    von Liebig J (1846) Animal chemistry, or chemistry in its application to physiology and pathology, third edn, part 1. Taylor and Walton, LondonGoogle Scholar
  7. 7.
    Parkes EA (1864) A manual of practical hygiene: prepared especially for use in the medical service of the army. J Churchill & Sons, LondonGoogle Scholar
  8. 8.
    League of Nations Technical Commission (1936) The problem of nutrition, volume 2. Report on physiological bases of nutrition. League of Nations Publication Department, GenevaGoogle Scholar
  9. 9.
    League of Nations Technical Commission (1938) Report by the technical commission on nutrition on the work of its third session. Bull Health Org 7:460–502Google Scholar
  10. 10.
    Ribot B, Aranda N, Viteri F, Hernandez-Martinez C, Canals J, Arija V (2012) Depleted iron stores without anaemia early in pregnancy carries increased risk of lower birthweight even when supplemented daily with moderate iron. Hum Reprod 27:1260–1266CrossRefGoogle Scholar
  11. 11.
    Clenin GE (2017) The treatment of iron deficiency without anaemia (in otherwise healthy persons). Swiss Med Wkly 147:w14434Google Scholar
  12. 12.
    Sawada T, Konomi A, Yokoi K (2014) Iron deficiency without anemia is associated with anger and fatigue in young Japanese women. Biol Trace Elem Res 159:22–31CrossRefGoogle Scholar
  13. 13.
    Hallberg L, Hulthén L, Bengtsson C, Lapidus L, Lindstedt G (1995) Iron balance in menstruating women. Eur J Clin Nutr 49:200–207Google Scholar
  14. 14.
    Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG (1998) Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 44:45–51Google Scholar
  15. 15.
    Lipschitz DA, Cook JD, Finch CA (1974) A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 290:1213–1216CrossRefGoogle Scholar
  16. 16.
    Zimmermann MB (2008) Methods to assess iron and iodine status. Br J Nutr 99(Suppl 3):S2–S9Google Scholar
  17. 17.
    Cook JD (2005) Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol 18:319–332CrossRefGoogle Scholar
  18. 18.
    Pasricha S-R, Casey GJ, Phuc TQ, Mihrshahi S, MacGregor L, Montresor A, Tien N, Biggs B-A (2009) Baseline iron indices as predictors of hemoglobin improvement in anemic Vietnamese women receiving weekly iron-folic acid supplementation and deworming. Am J Trop Med Hyg 81:1114–1119CrossRefGoogle Scholar
  19. 19.
    Yokoi K (2014) Estimation of iron requirements for women by numerical analysis of population-based data from the National Health and nutrition surveys of Japan 2003–2007. J Trace Elem Med Biol 28:453–458CrossRefGoogle Scholar
  20. 20.
    Peyrin-Biroulet L, Williet N, Cacoub P (2015) Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr 102:1585–1594CrossRefGoogle Scholar
  21. 21.
    Lehmann C, Mueller F, Munk I, Senator H, Zuntz N (1893) Untersuchungen an zwei hungernden Menschen. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin 131(Suppl):1–228Google Scholar
  22. 22.
    Ohlson MA, Daum K (1935) A study of the iron metabolism of normal women. J Nutr 9:75–89CrossRefGoogle Scholar
  23. 23.
    Roberts LJ (1944) Scientific basis for the recommended dietary allowances. N Y State J Med 44:59–66Google Scholar
  24. 24.
    Sherman HC (1941) Chemistry of food and nutrition, 6th edn. Macmillan Co., New YorkGoogle Scholar
  25. 25.
    Stockman R, Greig EDW (1897) Ingestion and excretion of iron in health. J Physiol 21:55–57CrossRefGoogle Scholar
  26. 26.
    von Wendt G (1905) Untersuchungen über den Eiweiss- und Salz-Stoffwechsel beim Menschen. Skand Arch Physiol 17:211–289CrossRefGoogle Scholar
  27. 27.
    Sherman HC (1907) Iron in food and its function in nutrition. Government Printing Office, Washington, DCGoogle Scholar
  28. 28.
    Reznikoff P, Toscani V, Fullarton R (1934) Iron metabolism studies in a normal subject and in a polycythemic patient. J Nutr 7:221–230CrossRefGoogle Scholar
  29. 29.
    Vahlteich EM, Funnell EH, Macleod G, Rose MS (1935) Egg yolk and bran as sources of iron in the human dietary. J Am Diet Assoc 11:331–334Google Scholar
  30. 30.
    Farrar GE Jr, Goldhamer SM (1935) The iron requirement of the normal human adult. J Nutr 10:241–254CrossRefGoogle Scholar
  31. 31.
    Institute of Medicine (2001) Dietary reference intakes for vitamin a, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy Press, Washington, DC, p 2000Google Scholar
  32. 32.
    Green R, Charlton R, Seftel H, Bothwell T, Mayet F, Adams B, Finch C, Layrisse M (1968) Body iron excretion in man. Am J Med 45:336–353CrossRefGoogle Scholar
  33. 33.
    Leverton RM (1941) Iron metabolism in human subjects on daily intakes of less than 5 milligrams. J Nutr 21:617–631CrossRefGoogle Scholar
  34. 34.
    Mertz W (1987) Use and misuse of balance studies. J Nutr 117:1811–1813CrossRefGoogle Scholar
  35. 35.
    FAO/WHO (1970) Requirements of ascorbic acid, vitamin D, vitamin B12, folate, and iron. Report of a joint FAO/WHO expert group, FAO/WHO. GenevaGoogle Scholar
  36. 36.
    Hallberg L, Hulthén L (2000) Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 71:1147–1160CrossRefGoogle Scholar
  37. 37.
    Magnusson B, Bjorn-Rassmussen E, Hallberg L, Rossander L (1981) Iron absorption in relation to iron status. Model proposed to express results to food iron absorption measurements. Scand J Haematol 27:201–208CrossRefGoogle Scholar
  38. 38.
    Valenzuela C, Olivares M, Brito A, Hamilton-West C, Pizarro F (2013) Is a 40% absorption of iron from a ferrous ascorbate reference dose appropriate to assess iron absorption independent of iron status? Biol Trace Elem Res 155:322–326CrossRefGoogle Scholar
  39. 39.
    Beard JL, Murray-Kolb LE, Haas JD, Lawrence F (2007) Iron absorption: comparison of prediction equations and reality. Results from a feeding trial in the Philippines. Int J Vitam Nutr Res 77:199–204CrossRefGoogle Scholar
  40. 40.
    Royston P (1993) A toolkit for testing for non-normality in complete and censored samples. J R Stat Soc Ser D 42:37–43Google Scholar
  41. 41.
    National Research Council (1986) Nutrient adequacy: assessment using food consumption surveys. In: National Academy Press, Washington, DCGoogle Scholar
  42. 42.
    Hallberg L, Rossander-Hultén L (1991) Iron requirements in menstruating women. Am J Clin Nutr 54:1047–1058CrossRefGoogle Scholar
  43. 43.
    WHO/FAO (2004) Human vitamin and mineral requirements: report of a joint FAO/WHO expert consultation, Bangkok, Thailand, 21–30 September 1998, 2nd edn. WHO/FAO, GenevaGoogle Scholar
  44. 44.
    Beaton G (1971) The concept and application of the FAO/WHO recommended intakes (esn: FAO/WHO/pr/71/12-ii). A document in the FAO/WHO ad hoc Committee of Expert on energy and protein: requirements and recommended intakes. Accessed 2018/8/09 http://www.fao.org/docrep/meeting/009/ae906e/ae906e33.Htm
  45. 45.
    Lörstad MH (1971) Recommended intake and its relation to nutrient deficiency. FAO Nutr Newsl 9:18–31Google Scholar
  46. 46.
    Yokoi K (2003) Numerical methods for estimating iron requirements from population data. Biol Trace Elem Res 95:155–172CrossRefGoogle Scholar
  47. 47.
    Beaton GH (1985) New approaches to the nutritional assessment of population data, accessed 2018/8/17 http://www.nutrientdataconf.org/pastconf/ndbc10/toc.Htm. 10th National Nutrient Databank Conference, July 22–24 3–5, 1985
  48. 48.
    Cai J, Ren T, Zhang Y, Wang Z, Gou L, Huang Z, Wang J, Piao J, Yang X, Yang L (2018) Iron physiological requirements in Chinese adults assessed by the stable isotope labeling technique. Nutr Metab (Lond) 15:29CrossRefGoogle Scholar
  49. 49.
    Hefnawi F, El-Zayat AF, Yacout MM (1980) Physiologic studies of menstrual blood loss. Int J Gynaecol Obstet 17:343–352CrossRefGoogle Scholar
  50. 50.
    Cole SK, Billewicz WZ, Thomson AM (1971) Sources of variation in menstrual blood loss. J Obstet Gynaecol Br Commonw 78:933–939CrossRefGoogle Scholar
  51. 51.
    Hallberg L, Hogdahl AM, Nilsson L, Rybo G (1966) Menstrual blood loss-a population study. Variation at different ages and attempts to define normality. Acta Obstet Gynecol Scand 45:320–351CrossRefGoogle Scholar
  52. 52.
    Beaton GH (1972) The use of nutritional requirements and allowances. In: Proceedings of the Western Hemisphere Nutrition Congress. Futura Press, New York, pp 356–363Google Scholar
  53. 53.
    Hale GE, Manconi F, Luscombe G, Fraser IS (2010) Quantitative measurements of menstrual blood loss in ovulatory and anovulatory cycles in middle- and late-reproductive age and the menopausal transition. Obstet Gynecol 115:249–256CrossRefGoogle Scholar
  54. 54.
    Hallberg L, Nilsson L (1964) Constancy of individual menstrual blood loss. Acta Obstet Gynecol Scand 43:352–359CrossRefGoogle Scholar
  55. 55.
    Finch CA (1959) Body iron exchange in man. J Clin Invest 38:392–396CrossRefGoogle Scholar
  56. 56.
    Bothwell TH, Finch CA (1968) Iron losses in man. In: Blix G (ed) Symposia of the Swedish Nutrition Foundation. 6. Occurrence, causes and prevention of nutritional anaemias. Almquist & Wiksells, Uppsala, pp 104–114Google Scholar
  57. 57.
    Canada (1983) Recommended nutrient intakes for Canadians. Canadian Govt. Pub. Centre, OttawaGoogle Scholar
  58. 58.
    National Research Council (1989) Recommended dietary allowances, 10th edn. National Academy Press, Washington, DCGoogle Scholar
  59. 59.
    Ministry of Health and Welfare, Japan (1999) Recommended dietary allowances, Dietary Reference Intakes, 6th edn. Daiichi Shuppan Publishing, Co., Ltd., TokyoGoogle Scholar
  60. 60.
    MacPhail AP, Simon MO, Torrance JD, Charlton RW, Bothwell TH, Isaacson C (1979) Changing patterns of dietary iron overload in black South Africans. Am J Clin Nutr 32:1272–1278CrossRefGoogle Scholar
  61. 61.
    Fomon SJ, Drulis JM, Nelson SE, Serfass RE, Woodhead JC, Ziegler EE (2003) Inevitable iron loss by human adolescents, with calculations of the requirement for absorbed iron. J Nutr 133:167–172CrossRefGoogle Scholar
  62. 62.
    Fomon SJ, Nelson SE, Serfass RE, Ziegler EE (2005) Absorption and loss of iron in toddlers are highly correlated. J Nutr 135:771–777CrossRefGoogle Scholar
  63. 63.
    Loussouarn G, Lozano I, Panhard S, Collaudin C, El Rawadi C, Genain G (2016) Diversity in human hair growth, diameter, colour and shape. An in vivo study on young adults from 24 different ethnic groups observed in the five continents. Eur J Dermatol 26:144–154Google Scholar
  64. 64.
    Nohynek GJ, Fautz R, Benech-Kieffer F, Toutain H (2004) Toxicity and human health risk of hair dyes. Food Chem Toxicol 42:517–543CrossRefGoogle Scholar
  65. 65.
    International Commission on Radiological Protection (1975) Report of the task group on reference man, ICRP publication 23. Pergamon Press, OxfordGoogle Scholar
  66. 66.
    Iyengar GV, Kollmer WE, Bowen HJM (1978) The elemental composition of human tissues and body fluids. Verlag Chemie, WeinheimGoogle Scholar
  67. 67.
    Baden HP (1970) The physical properties of nail. J Invest Dermatol 55:115–122CrossRefGoogle Scholar
  68. 68.
    Ficheux AS, Morisset T, Chevillotte G, Postic C, Roudot AC (2014) Probabilistic assessment of exposure to nail cosmetics in french consumers. Food Chem Toxicol 66:36–43CrossRefGoogle Scholar
  69. 69.
    Yamaguchi A (1995) The relation between incurvated nail plate width and the transverse width of distal phalanx-a CT scan study. J Showa Med Assoc 55:230–235Google Scholar
  70. 70.
    Yaemsiri S, Hou N, Slining M, He K (2010) Growth rate of human fingernails and toenails in healthy American young adults. J Eur Acad Dermatol Venereol 24:420–423CrossRefGoogle Scholar
  71. 71.
    Sobolewski S, Lawrence AC, Bagshaw P (1978) Human nails and body iron. J Clin Pathol 31:1068–1072CrossRefGoogle Scholar
  72. 72.
    Tang Y-R, Zhang S-Q, Xiong Y, Zhao Y, Fu H, Zhang H-P, Xiong K-M (2003) Studies of five microelement contents in human serum, hair, and fingernails correlated with aged hypertension and coronary heart disease. Biol Trace Elem Res 92:97–103CrossRefGoogle Scholar
  73. 73.
    Rodushkin I, Axelsson MD (2000) Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part II. A study of the inhabitants of northern Sweden. Sci Total Environ 262:21–36CrossRefGoogle Scholar
  74. 74.
    Molin L, Wester P (1973) Iron content in normal and psoriatic epidermis. Acta Derm Venereol 53:473–476Google Scholar
  75. 75.
    Brune M, Magnusson B, Persson H, Hallberg L (1986) Iron losses in sweat. Am J Clin Nutr 43:438–443CrossRefGoogle Scholar
  76. 76.
    Jacob RA, Sandstead HH, Munoz JM, Klevay LM, Milne DB (1981) Whole body surface loss of trace metals in normal males. Am J Clin Nutr 34:1379–1383CrossRefGoogle Scholar
  77. 77.
    Shetage SS, Traynor MJ, Brown MB, Raji M, Graham-Kalio D, Chilcott RP (2014) Effect of ethnicity, gender and age on the amount and composition of residual skin surface components derived from sebum, sweat and epidermal lipids. Skin Res Technol 20:97–107CrossRefGoogle Scholar
  78. 78.
    Thody AJ, Shuster S (1989) Control and function of sebaceous glands. Physiol Rev 69:383–416CrossRefGoogle Scholar
  79. 79.
    Rodushkin I, Axelsson MD (2000) Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part I. analytical methodology. Sci Total Environ 250:83–100CrossRefGoogle Scholar
  80. 80.
    Cai Y (2011) Determination of select trace elements in hair of college students in Jinzhou, China. Biol Trace Elem Res 144:469–474CrossRefGoogle Scholar
  81. 81.
    Croft DN (1970) Body iron loss and cell loss from epithelia. Proc R Soc Med 63:1221–1224Google Scholar

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Authors and Affiliations

  1. 1.Department of Human NutritionSeitoku University Graduate SchoolMatsudoJapan

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