Plasma Selenium and Cadmium Levels in Patients with Chronic Otitis Media in a Turkish Population and Their Relation to Inflammation Markers
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Chronic otitis media (COM) is a multifactorial process, for which a clear etiology has not yet been established. The aims of the present study were to evaluate selenium (Se) and cadmium (Cd) levels in patients with COM and to analyze the correlation between Se and Cd with inflammation markers. The study population consisted of 88 participants: 45 healthy controls (group 1) and 43 patients with COM (group 2). Demographic data, Se, Cd, C-reactive protein (CRP), and white blood cell count (WBC) levels were all recorded. Se and Cd measurements were performed in a graphite furnace atomic absorption spectrophotometer (Perkin Elmer Analyst 800) using Zeeman background correction. The Se and Cd levels were compared between the groups and the correlation between Se and Cd with inflammation markers was analyzed. No statistically significant difference was determined between the groups in terms of demographic data (p > 0.05). CRP and WBC levels were significantly higher in group 2 than in group 1 (p < 0.05). Se levels were significantly lower in group 2 than in group 1, at 23.40 ± 12.08 μg/L vs. 37.31 ± 22.44 μg/L (p < 0.05). Cd levels were significantly higher in group 2 than in group 1, at 1.79 ± 1.63 μg/L vs. 0.68 ± 0.45 μg/L (p < 0.05). When all the cases were evaluated together, a statistically significant negative correlation was determined between Se and CRP (r = − 0.239, p = 0.013) and a positive correlation between Cd and CRP (r = 0.266, p = 0.006), WBC (r = 0.258, p = 0.008). Our results could propose that Se deficiency and Cd excess could play a crucial and additive role in the etiopathogenesis of COM. However, further investigations with larger numbers of patients are warranted to determine the exact role of these elements.
KeywordsChronic otitis media Selenium Cadmium Oxidative stress Inflammation
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Conflict of Interest
The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.
- 13.Bacic’Vrca V, Skreb F, Cepelak I, Mayer L (2004) Supplementation with antioxidants in the treatment of graves’ disease: the effect on the extracellular antioxidative parameters. Acta Pharma 54:79–89Google Scholar
- 16.Hall JA, Bobe G, Vorachek WR, Kasper K, Traber MG, Mosher WD, Pirelli GJ, Gamroth M (2014) Effect of supranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and inflammation biomarkers in selenium-replete dairy cows. Biol Trace Elem Res 161:272–287CrossRefGoogle Scholar
- 23.Asher BF, Guilford FT (2016) Oxidative stress and low glutathione in common ear, nose, and throat conditions: a systematic review. Altern Ther Health Med 22:44–50Google Scholar
- 26.Wang B, Du Y (2013) Cadmium and its neurotoxic effects. Oxid Med Cell Longev 2013:898034Google Scholar
- 40.Shukla GK, Mahajan A, Pandey S, Gujrati VR, Vrat S, Mishra SC, Shanker K (1996) A study of free radicals and scavenging enzyme in tonsillitis. Boll Chim Farm 135:653–655Google Scholar
- 44.Parks RR, Huang CC, Haddad J (1994) Evidence of oxygen radical injury in experimental otitis media. Laryngoscope 104:1389–1392Google Scholar
- 46.Khakimov AM, Arifov SS, Faizulaeva FN (1997) Efficacy of antioxidant therapy in patients with acute and chronic purulent otitis media. Vestn Otorinolaringol 5:16–19Google Scholar
- 49.Aktan B, Taysi S, Gumustekin K, Bakan N, Sutbeyaz Y (2003) Evaluation of oxidative stress in erythrocytes of Guinea pigs with experimental otitis media and effusion. Ann Clin Lab Sci 33:232–236Google Scholar
- 63.Panjehpour M, Alaie SH (2014) N-acetylcysteine prevents cadmium-induced apoptosis in human breast cancer MDA-MB468 cell line. Cell Mol Biol 60:33–38Google Scholar
- 73.Wong SL, Lye EJ (2008) Lead, mercury, and cadmium levels in Canadians. Health Rep 19:31–36Google Scholar
- 76.Manzanares W, Hardy G (2012) Pharmaconutrition with antioxidants in the critically ill: is selenium the cornerstone of this strategy? ICU Manag 4:22Google Scholar
- 79.Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, Ghandi Y, Bagherian T, Asemi Z (2016) Selenium supplementation and the effects on reproductive outcomes, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome. Horm Metab Res 48:185–190Google Scholar