Biological Trace Element Research

, Volume 187, Issue 1, pp 224–229 | Cite as

Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice

  • Kyunghwa Sung
  • Minjeong Kim
  • Haesoo Kim
  • Gi-Wook Hwang
  • Kisok KimEmail author


Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects.


Arsenic Glutamate mGluR2 mGluR3 Striatum VGLUT2 



This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. NRF-2016R1A2B4011596).

Compliance with Ethical Standards

All experimental protocols were approved by the Institutional Animal Care and Use Committee of Keimyung University (approval no. KM-2014-78R2). Experiments were conducted according to NIH guidelines for the care and use of laboratory animals.

Conflict of Interest

The authors declare that they have no conflict of interests.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Collage of PharmacyKeimyung UniversityDaeguRepublic of Korea
  2. 2.Collage of PharmacyEwha Woman’s UniversitySeoulRepublic of Korea
  3. 3.Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical SciencesTohoku UniversitySendaiJapan

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