Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?
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Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues. Following a single dose 400 mg/70 kg magnesium administration to Sprague Dawley rats, bioavailability was evaluated by examining time-dependent absorption, tissue penetration, and the effects on the behavior of the animals. Pharmacokinetically, the area under the curve calculation is highest in the magnesium malate. The magnesium acetyl taurate was found to have the second highest area under the curve calculation. Magnesium acetyl taurate was rapidly absorbed, able to pass through to the brain easily, had the highest tissue concentration level in the brain, and was found to be associated with decreased anxiety indicators. Magnesium malate levels remained high for an extended period of time in the serum. The commonly prescribed dietary supplements magnesium oxide and magnesium citrate had the lowest bioavailability when compared to our control group. More research is needed to investigate the bioavailability of magnesium malate and acetyl taurate compounds and their effects in specific tissues and on behavior.
KeywordsMagnesium acetyl taurate Magnesium malate Magnesium citrate Magnesium oxide Magnesium sulfate Anxiety Brain Muscle
Compliance with Ethical Standards
The experiments were carried out according to the Guiding Principles in the Use of Experimental Animals and approved by the Animal Care and Use Committee of the Dokuz Eylul University, School of Medicine.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 2.Swaminathan R (2003) Magnesium metabolism and its disorders. The Clinical biochemist Reviews / Australian Association of Clinical Biochemists 24(2):47–66Google Scholar
- 7.Boyle NB, Lawton C, Dye L (2017) The effects of magnesium supplementation on subjective anxiety and stress—a systematic review. Nutrients 9(5)Google Scholar
- 11.c (1997) National research, DRI (dietary reference intakes) for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy Press, WashingtonGoogle Scholar
- 19.Schuette SA, Lashner BA, Janghorbani M (1994) Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr 18(5):430–435Google Scholar
- 31.Iezhitsa IN, Spasov AA, Kharitonova MV, Kravchenko MS (2011) Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan. Nutr Neurosci 14(1):10–24CrossRefGoogle Scholar