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Biological Trace Element Research

, Volume 186, Issue 1, pp 12–20 | Cite as

Hair Trace Elements in Overweight and Obese Adults in Association with Metabolic Parameters

  • Margarita G. Skalnaya
  • Anatoly V. Skalny
  • Andrey R. Grabeklis
  • Eugeny P. Serebryansky
  • Vasily A. Demidov
  • Alexey A. Tinkov
Article

Abstract

The objective of the present study was to investigate the level of toxic and essential trace elements in hair of adult overweight and obese persons as well as its association with metabolic parameters. Hair trace element levels were assessed using inductively coupled plasma mass-spectrometry in 112 overweight and obese patients and 106 lean controls. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, uric acid (UA) levels, and cholinesterase (CE) and gamma-glutamyltransferase (GGT) activity were also assessed. Excessive body weight significantly affected hair trace element levels. In particular, hair Co (33%), Cu (13%), I (30%), Mg (2-fold), Mn (25%), Zn (17%), and Ni (21%) levels were lower, whereas Al (14%) and As levels were higher in comparison to those in the control group. Correlation analysis demonstrated the most significant correlations for hair Mg with body weight, BMI, systolic and diastolic blood pressure, and UA, and for hair Al with body weight, BMI, TC, glucose, TG, CE, GGT, and UA. Multiple regression analysis demonstrated that trace elements were not associated with TC and LDL-C levels neither in crude nor in adjusted models. In turn, crude and adjusted models accounted for 25 and 43% of serum TG variance. The most significant associations were observed for hair Al, Fe, Si, and V in adjusted model. The obtained data demonstrate that obesity-related metabolic disorders may be at least partially mediated by altered trace element and mineral levels.

Keywords

Obesity Dyslipidemia Metabolic syndrome Aluminum Magnesium 

Notes

Funding Information

The publication was prepared with the support of the “RUDN University Program 5-100”.

Compliance with Ethical Standards

All procedures performed were in agreement with the ethical principles of the Declaration of Helsinki and its later amendments. All volunteers were informed about the experimental procedures and signed the informed consent form prior the investigation. The protocol of the present study was approved by the local ethics committee at the Institute of Bioelementology (Orenburg, Russia).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Margarita G. Skalnaya
    • 1
  • Anatoly V. Skalny
    • 1
    • 2
    • 3
  • Andrey R. Grabeklis
    • 1
    • 2
  • Eugeny P. Serebryansky
    • 4
  • Vasily A. Demidov
    • 4
  • Alexey A. Tinkov
    • 1
    • 2
  1. 1.Peoples’ Friendship University of Russia (RUDN University)MoscowRussia
  2. 2.Yaroslavl State UniversityYaroslavlRussia
  3. 3.Institute of BioelementologyOrenburg State UniversityOrenburgRussia
  4. 4.Russian Society for Trace Elements in MedicineMoscowRussia

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