Cadmium Profiles in Dental Calculus: a Cross-Sectional Population-Based Study in Hunan Province of China
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We aimed to investigate whether the cadmium concentrations differ in human dental calculus obtained from the residents with no smoking living in the contaminated area and those with no smoking living in noncontaminated area. In total, there were 260 samples of dental calculus from the adults (n = 50) with no smoking living in contaminated area, the adults (n = 60) with no smoking living in mountainous area, and the adults (n = 150) with no smoking living in low altitude area in Hunan province of China. All samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) for cadmium levels. The cadmium levels in dental calculus were significantly higher in the adults with no smoking living in contaminated area than those living in mountainous area and in low altitude area (p < 0.01). The cadmium levels in dental calculus were also higher in the adults with no smoking living in low altitude area than those living in mountainous region (p < 0.01). The results suggested that measuring cadmium levels in dental calculus may be a useful noninvasive method for analysis of environmental exposure to cadmium in the human oral cavity. The low altitude region may have an area contaminated with cadmium in Hunan province of China.
KeywordsCadmium Dental calculus Biomarker Altitude Pollution ICP-MS
The authors would like to thank Dr. and Prof. Tian-Ting Zhang, at The Third Xiangya Hospital, Changsha, Hunan, PR China, for encouragement and support for this study.
Dr. Bo Zhang, Dr. Xiaodan Tan, and Mr. Kunlun Zhang contributed equally to this work. Dr. Bo Zhang, Dr. Xiaodan Tan and Mr. Kunlun Zhang participated in the study design. Dr. Bo Zhang, Dr. Xiaodan Tan and Mr. Kunlun Zhang collected dental calculus samples. Dr. Bo Zhang and Dr. Xiaodan Tan performed experiments. Dr. Bo Zhang analyzed data. Dr. Bo Zhang and Dr. Xiaodan Tan wrote the paper. All authors read and approved the paper.
This study was supported by Hunan S & T Project of China Hunan provincial science and technology department (Grant No. 2014FJ3032).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
- 1.Nawrot TS, Staessen JA, Roels HA, Munters E, Cuypers A, Richart T, Ruttens A, Smeets K, Clijsters H, Vangronsveld J (2010) Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 23(5):769–782. https://doi.org/10.1007/s10534-010-9343-z CrossRefPubMedGoogle Scholar
- 4.Dobrowolski R, Klatka J, Brodnjak-Voncina D, Trojanowska A, Mysliwiec D, Ostrowski J, Remer M (2014) Chemometric methods for studying the relationships between trace elements in laryngeal cancer and healthy tissues. Biol Trace Elem Res 159(1–3):107–114. https://doi.org/10.1007/s12011-014-0013-9 CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Yaprak E, Yolcubal İ, Sinanoğlu A, Doğrul-Demiray A, Guzeldemir-Akcakanat E, Marakoğlu I (2017) High levels of heavy metal accumulation in dental calculus of smokers: a pilot inductively coupled plasma mass spectrometry study. J Periodont Res 52(1):83–88. https://doi.org/10.1111/jre.12371 CrossRefPubMedGoogle Scholar
- 10.Ikeda M, Fukui Y, Ohashi F, Sakuragi S, Moriguchi J (2011) Low cadmium levels in urine of residents in two prefectures where cadmium levels in locally harvested brown rice are higher than in other prefectures in Japan. Biol Trace Elem Res 139(2):217–227. https://doi.org/10.1007/s12011-010-8646-9 CrossRefPubMedGoogle Scholar
- 16.Herman M, Golasik M, Piekoszewski W, Walas S, Napierala M, Wyganowska-Swiatkowska M, Kurhanska-Flisykowska A, Wozniak A, Florek E (2016) Essential and toxic metals in oral fluid-a potential role in the diagnosis of periodontal diseases. Biol Trace Elem Res 173(2):275–282. https://doi.org/10.1007/s12011-016-0660-0 CrossRefPubMedPubMedCentralGoogle Scholar
- 18.Winiarska-Mieczan A, Florek M, Kwiecień M, Kwiatkowska K, Krusiński R (2017) Cadmium and lead content in chosen commercial fishery products consumed in Poland and risk estimations on fish consumption. Biol Trace Elem Res. https://doi.org/10.1007/s12011-017-1104-1
- 19.Afridi HI, Talpur FN, Kazi TG, Brabazon D (2015) Effect of trace and toxic elements of different brands of cigarettes on the essential elemental status of Irish referent and diabetic mellitus consumers. Biol Trace Elem Res 167(2):209–224. https://doi.org/10.1007/s12011-015-0308-5 CrossRefPubMedGoogle Scholar
- 22.Nawrot T, Plusquin M, Hogervorst J, Roels HA, Celis H, Thijs L, Vangronsveld J, Van Hecke E, Staessen JA (2006) Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol 7(2):119–126. https://doi.org/10.1016/S1470-2045(06)70545-9 CrossRefPubMedGoogle Scholar
- 24.Gašparík J, Binkowski ŁJ, Jahnátek A, Šmehýl P, Dobiaš M, Lukáč N, Błaszczyk M, Semla M, Massanyi P (2017) Levels of metals in kidney, liver, and muscle tissue and their influence on the fitness for the consumption of wild boar from western Slovakia. Biol Trace Elem Res 177(2):258–266. https://doi.org/10.1007/s12011-016-0884-z CrossRefPubMedGoogle Scholar
- 27.Sponder M, Fritzer-Szekeres M, Marculescu R, Mittlböck M, Uhl M, Köhler-Vallant B, Strametz-Juranek J (2014) Blood and urine levels of heavy metal pollutants in female and male patients with coronary artery disease. Vasc Health Risk Manag 10:311–317. https://doi.org/10.2147/VHRM.S61510 CrossRefPubMedPubMedCentralGoogle Scholar
- 32.Monnet TF, Zurich MG, Boschat C, Corbaz A, Honegger P (2006) Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health 21:105–117Google Scholar
- 38.Zeng X, Liu Y, You S, Zeng G, Tan X, Hu X, Huang L, Li F (2015) Spatial distribution, health risk assessment and statistical source identification of the trace elements in surface water from the Xiangjiang River, China. Environ Sci Pollut Res Int 22(12):9400–9412. https://doi.org/10.1007/s11356-014-4064-4 CrossRefPubMedGoogle Scholar
- 42.Jazestani M, Chiniforoshan H, Tabrizi L, McArdle P (2016) Synthesis and crystal structures of cobalt(II), cadmium(II), and zinc(II) complexes of 4-nitro phenylcyanamide: enhancing the biological properties through bound to human serum albumin. J Biomol Struct Dyn 16:1–11Google Scholar
- 46.Kiziler AR, Aydemir B, Onaran I, Alici B, Ozkara H, Gulyasar T, Akyolcu MC (2007) High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects. Biol Trace Elem Res 120(1–3):82–91. https://doi.org/10.1007/s12011-007-8020-8 CrossRefPubMedGoogle Scholar
- 55.Mandel ID (1987) Calculus formation and prevention: an overview. Compend Suppl 8:S235–S241Google Scholar
- 60.Abdazimov AD (1991) Changes in the trace clement composition of the hard dental tissues, dental calculus, saliva and gingival biopsies in workers under the influence of unfavorable factors in the manufacture of Cu, Zn and Pb. Stomatohgiia Mosk 70:22–25Google Scholar
- 63.Costa de Almeida GR, Pereira Saraiva Mda C, Barbosa F Jr, Krug FJ, Cury JA, Rosário de Sousa Mda L, Rabelo Buzalaf MA, Gerlach RF (2007) Lead contents in the surface enamel of deciduous teeth sampled in vivo from children in uncontaminated and in lead-contaminated areas. Environ Res 104(3):337–345. https://doi.org/10.1016/j.envres.2007.03.007 CrossRefPubMedGoogle Scholar
- 66.Alhasmi AM, Gondal MA, Nasr MM, Shafik S, Habibullah YB (2015) Detection of toxic elements using laser-induced breakdown spectroscopy in smokers’ and nonsmokers’ teeth and investigation of periodontal parameters. Appl Opt 54(24):7342–7349. https://doi.org/10.1364/AO.54.007342 CrossRefPubMedGoogle Scholar