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Biological Trace Element Research

, Volume 185, Issue 1, pp 63–70 | Cite as

Cadmium Profiles in Dental Calculus: a Cross-Sectional Population-Based Study in Hunan Province of China

  • Bo Zhang
  • Xiaodan Tan
  • Kunlun Zhang
Article
  • 78 Downloads

Abstract

We aimed to investigate whether the cadmium concentrations differ in human dental calculus obtained from the residents with no smoking living in the contaminated area and those with no smoking living in noncontaminated area. In total, there were 260 samples of dental calculus from the adults (n = 50) with no smoking living in contaminated area, the adults (n = 60) with no smoking living in mountainous area, and the adults (n = 150) with no smoking living in low altitude area in Hunan province of China. All samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) for cadmium levels. The cadmium levels in dental calculus were significantly higher in the adults with no smoking living in contaminated area than those living in mountainous area and in low altitude area (p < 0.01). The cadmium levels in dental calculus were also higher in the adults with no smoking living in low altitude area than those living in mountainous region (p < 0.01). The results suggested that measuring cadmium levels in dental calculus may be a useful noninvasive method for analysis of environmental exposure to cadmium in the human oral cavity. The low altitude region may have an area contaminated with cadmium in Hunan province of China.

Keywords

Cadmium Dental calculus Biomarker Altitude Pollution ICP-MS 

Notes

Acknowledgements

The authors would like to thank Dr. and Prof. Tian-Ting Zhang, at The Third Xiangya Hospital, Changsha, Hunan, PR China, for encouragement and support for this study.

Contributors

Dr. Bo Zhang, Dr. Xiaodan Tan, and Mr. Kunlun Zhang contributed equally to this work. Dr. Bo Zhang, Dr. Xiaodan Tan and Mr. Kunlun Zhang participated in the study design. Dr. Bo Zhang, Dr. Xiaodan Tan and Mr. Kunlun Zhang collected dental calculus samples. Dr. Bo Zhang and Dr. Xiaodan Tan performed experiments. Dr. Bo Zhang analyzed data. Dr. Bo Zhang and Dr. Xiaodan Tan wrote the paper. All authors read and approved the paper.

Funding

This study was supported by Hunan S & T Project of China Hunan provincial science and technology department (Grant No. 2014FJ3032).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Nawrot TS, Staessen JA, Roels HA, Munters E, Cuypers A, Richart T, Ruttens A, Smeets K, Clijsters H, Vangronsveld J (2010) Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 23(5):769–782.  https://doi.org/10.1007/s10534-010-9343-z CrossRefPubMedGoogle Scholar
  2. 2.
    Veeriah V, Saran U, Swaminathan A, Balaguru UM, Thangaraj P, Nagarajan S, Rajendran VK, Chatterjee S (2015) Cadmium-induced embryopathy: nitric oxide rescues teratogenic effects of cadmium. Toxicol Sci 144(1):90–104.  https://doi.org/10.1093/toxsci/kfu258 CrossRefPubMedGoogle Scholar
  3. 3.
    Jin YH, Clark AB, Slebos BJC, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA (2003) Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 34(3):326–329.  https://doi.org/10.1038/ng1172 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Dobrowolski R, Klatka J, Brodnjak-Voncina D, Trojanowska A, Mysliwiec D, Ostrowski J, Remer M (2014) Chemometric methods for studying the relationships between trace elements in laryngeal cancer and healthy tissues. Biol Trace Elem Res 159(1–3):107–114.  https://doi.org/10.1007/s12011-014-0013-9 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Järup L, Rogenfelt A, Elinder CG, Nogawa K, Kjellström T (1983) Biological half-time of cadmium in the blood of workers after cessation of exposure. Scand J Work Environ Health 9(4):327–331.  https://doi.org/10.5271/sjweh.2404 CrossRefPubMedGoogle Scholar
  6. 6.
    Chen B, Lamberts LV, Behets GJ, Zhao T, Zhou M, Liu G, Hou X, Guan G, D'Haese PC (2009) Selenium, lead, and cadmium levels in renal failure patients in China. Biol Trace Elem Res 131(1):1–12.  https://doi.org/10.1007/s12011-009-8340-y CrossRefPubMedGoogle Scholar
  7. 7.
    Yaprak E, Yolcubal İ, Sinanoğlu A, Doğrul-Demiray A, Guzeldemir-Akcakanat E, Marakoğlu I (2017) High levels of heavy metal accumulation in dental calculus of smokers: a pilot inductively coupled plasma mass spectrometry study. J Periodont Res 52(1):83–88.  https://doi.org/10.1111/jre.12371 CrossRefPubMedGoogle Scholar
  8. 8.
    Sawidis T, Krystallidis P, Veros D, Chettri M (2012) A study of air pollution with heavy metals in Athens city and Attica basin using evergreen trees as biological indicators. Biol Trace Elem Res 148(3):396–408.  https://doi.org/10.1007/s12011-012-9378-9 PubMedCrossRefGoogle Scholar
  9. 9.
    Kim Y, Lobdell DT, Wright CW, Gocheva VV, Hudgens E, Bowler RM (2015) Blood metal concentrations of manganese, lead, and cadmium in relation to serum ferritin levels in Ohio residents. Biol Trace Elem Res 165(1):1–9.  https://doi.org/10.1007/s12011-014-0223-1 CrossRefPubMedGoogle Scholar
  10. 10.
    Ikeda M, Fukui Y, Ohashi F, Sakuragi S, Moriguchi J (2011) Low cadmium levels in urine of residents in two prefectures where cadmium levels in locally harvested brown rice are higher than in other prefectures in Japan. Biol Trace Elem Res 139(2):217–227.  https://doi.org/10.1007/s12011-010-8646-9 CrossRefPubMedGoogle Scholar
  11. 11.
    Shariati F, Esaili Sari A, Mashinchian A, Pourkazemi M (2011) Metallothionein as potential biomarker of cadmium exposure in Persian sturgeon (Acipenser persicus). Biol Trace Elem Res 143(1):281–291.  https://doi.org/10.1007/s12011-010-8877-9 CrossRefPubMedGoogle Scholar
  12. 12.
    Ostadrahimi A, Payahoo L, Somi MH, Khajebishak Y (2017) The association between urinary cadmium levels and dietary habits with risk of gastrointestinal cancer in Tabriz, northwest of Iran. Biol Trace Elem Res 175(1):72–78.  https://doi.org/10.1007/s12011-016-0764-6 CrossRefPubMedGoogle Scholar
  13. 13.
    Akcali A, Lang NP (2018) Dental calculus: the calcified biofilm and its role in disease development. Periodontol 76(1):109–115.  https://doi.org/10.1111/prd.12151 CrossRefGoogle Scholar
  14. 14.
    Jepsen S, Deschner J, Braun A, Schwarz F, Eberhard J (2011) Calculus removal and the prevention of its formation. Periodontol 55(1):167–188.  https://doi.org/10.1111/j.1600-0757.2010.00382.x CrossRefGoogle Scholar
  15. 15.
    McDougall WA (1985) Analytical transmission electron microscopy of the distribution of elements in human supragingival dental calculus. Arch Oral Biol 30(8):603–608.  https://doi.org/10.1016/0003-9969(85)90080-9 CrossRefPubMedGoogle Scholar
  16. 16.
    Herman M, Golasik M, Piekoszewski W, Walas S, Napierala M, Wyganowska-Swiatkowska M, Kurhanska-Flisykowska A, Wozniak A, Florek E (2016) Essential and toxic metals in oral fluid-a potential role in the diagnosis of periodontal diseases. Biol Trace Elem Res 173(2):275–282.  https://doi.org/10.1007/s12011-016-0660-0 CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Kim YJ, Kim YK, Kho HS (2010) Effects of smoking on trace metal levels in saliva. Oral Dis 16(8):823–830.  https://doi.org/10.1111/j.1601-0825.2010.01698.x CrossRefPubMedGoogle Scholar
  18. 18.
    Winiarska-Mieczan A, Florek M, Kwiecień M, Kwiatkowska K, Krusiński R (2017) Cadmium and lead content in chosen commercial fishery products consumed in Poland and risk estimations on fish consumption. Biol Trace Elem Res.  https://doi.org/10.1007/s12011-017-1104-1
  19. 19.
    Afridi HI, Talpur FN, Kazi TG, Brabazon D (2015) Effect of trace and toxic elements of different brands of cigarettes on the essential elemental status of Irish referent and diabetic mellitus consumers. Biol Trace Elem Res 167(2):209–224.  https://doi.org/10.1007/s12011-015-0308-5 CrossRefPubMedGoogle Scholar
  20. 20.
    Ni B, Tian W, Nie H, Wang P, He G (1999) Study on air pollution in Beijing’s major industrial areas using multielements in biomonitors and NAA techniques. Biol Trace Elem Res 71-72(1):267–272.  https://doi.org/10.1007/BF02784212 CrossRefPubMedGoogle Scholar
  21. 21.
    Järup L, Akesson A (2009) Current status of Cd as an environmental health problem. Toxicol Appl Pharmacol 238(3):201–208.  https://doi.org/10.1016/j.taap.2009.04.020 CrossRefPubMedGoogle Scholar
  22. 22.
    Nawrot T, Plusquin M, Hogervorst J, Roels HA, Celis H, Thijs L, Vangronsveld J, Van Hecke E, Staessen JA (2006) Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol 7(2):119–126.  https://doi.org/10.1016/S1470-2045(06)70545-9 CrossRefPubMedGoogle Scholar
  23. 23.
    Bargagli E, Monaci F, Bianchi N, Bucci C, Rottoli P (2008) Analysis of trace elements in bronchoalveolar lavage of patients with diffuse lung diseases. Biol Trace Elem Res 124(3):225–235.  https://doi.org/10.1007/s12011-008-8143-6 CrossRefPubMedGoogle Scholar
  24. 24.
    Gašparík J, Binkowski ŁJ, Jahnátek A, Šmehýl P, Dobiaš M, Lukáč N, Błaszczyk M, Semla M, Massanyi P (2017) Levels of metals in kidney, liver, and muscle tissue and their influence on the fitness for the consumption of wild boar from western Slovakia. Biol Trace Elem Res 177(2):258–266.  https://doi.org/10.1007/s12011-016-0884-z CrossRefPubMedGoogle Scholar
  25. 25.
    Chen X, Zhu G, Jin T, Wang Z (2013) Effects of cadmium on bone mineral density in the distal and proximal forearm: two female population studies in China. Biol Trace Elem Res 156(1–3):45–48.  https://doi.org/10.1007/s12011-013-9838-x CrossRefPubMedGoogle Scholar
  26. 26.
    Moulis JM (2010) Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals 23(5):877–896.  https://doi.org/10.1007/s10534-010-9336-y CrossRefPubMedGoogle Scholar
  27. 27.
    Sponder M, Fritzer-Szekeres M, Marculescu R, Mittlböck M, Uhl M, Köhler-Vallant B, Strametz-Juranek J (2014) Blood and urine levels of heavy metal pollutants in female and male patients with coronary artery disease. Vasc Health Risk Manag 10:311–317.  https://doi.org/10.2147/VHRM.S61510 CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Zhang L, Lv J, Liao C (2012) Dietary exposure estimates of 14 trace elements in Xuanwei and Fuyuan, two high lung cancer incidence areas in China. Biol Trace Elem Res 146(3):287–292.  https://doi.org/10.1007/s12011-011-9252-1 CrossRefPubMedGoogle Scholar
  29. 29.
    Hyder O, Chung M, Cosgrove D, Herman JM, Li Z, Firoozmand A, Gurakar A, Koteish A, Pawlik TM (2013) Cadmium exposure and liver disease among US adults. J Gastrointest Surg 17(7):1265–1273.  https://doi.org/10.1007/s11605-013-2210-9 CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Nordberg G, Jin T, Wu X, Lu J, Chen L, Liang Y, Lei L, Hong F, Bergdahl IA, Nordberg M (2012) Kidney dysfunction and cadmium exposure—factors influencing dose-response relationships. J Trace Elem Med Bio 26(2-3):197–200.  https://doi.org/10.1016/j.jtemb.2012.03.007 CrossRefGoogle Scholar
  31. 31.
    Wu Q, Magnus JH, Hentz JG (2010) Urinary cadmium, osteopenia, and osteoporosis in the US population. Osteoporos Int 21(8):1449–1454.  https://doi.org/10.1007/s00198-009-1111-y CrossRefPubMedGoogle Scholar
  32. 32.
    Monnet TF, Zurich MG, Boschat C, Corbaz A, Honegger P (2006) Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health 21:105–117Google Scholar
  33. 33.
    Hartwig A (2013) Cadmium and cancer. Met Ions Life Sci 11:491–507.  https://doi.org/10.1007/978-94-007-5179-8_15 CrossRefPubMedGoogle Scholar
  34. 34.
    Cobanoglu U, Demir H, Sayir F, Duran M, Mergan D (2010) Some mineral, trace element and heavy metal concentrations in lung cancer. Asian Pac J Cancer Prev 11(5):1383–1388PubMedGoogle Scholar
  35. 35.
    Liu HY, Probst A, Liao BH (2005) Metal contamination of soils and crops affected by the Chenzhou lead/zinc mine spill (Hunan, China). Sci Total Environ 339(1-3):153–166.  https://doi.org/10.1016/j.scitotenv.2004.07.030 CrossRefPubMedGoogle Scholar
  36. 36.
    Yang QW, Lan CY, Wang HB, Zhuang P, Shu WS (2006) Cadmium in soilrice system and health risk associated with the use of untreated mining wastewater for irrigation in Lechang, China. Agric Water Manag 84(1-2):147–152.  https://doi.org/10.1016/j.agwat.2006.01.005 CrossRefGoogle Scholar
  37. 37.
    Wang D, Jiang X, Rao W, He J (2009) Kinetics of soil cadmium desorption under simulated acid rain. Ecol Complex 6(4):432–437.  https://doi.org/10.1016/j.ecocom.2009.03.010 CrossRefGoogle Scholar
  38. 38.
    Zeng X, Liu Y, You S, Zeng G, Tan X, Hu X, Huang L, Li F (2015) Spatial distribution, health risk assessment and statistical source identification of the trace elements in surface water from the Xiangjiang River, China. Environ Sci Pollut Res Int 22(12):9400–9412.  https://doi.org/10.1007/s11356-014-4064-4 CrossRefPubMedGoogle Scholar
  39. 39.
    Lech T, Sadlik JK (2017) Cadmium concentration in human autopsy tissues. Biol Trace Elem Res 179(2):172–177.  https://doi.org/10.1007/s12011-017-0959-5 CrossRefPubMedGoogle Scholar
  40. 40.
    Qayyum MA, Shah MH (2014) Comparative study of trace elements in blood, scalp hair and nails of prostate cancer patients in relation to healthy donors. Biol Trace Elem Res 162(1-3):46–57.  https://doi.org/10.1007/s12011-014-0123-4 CrossRefPubMedGoogle Scholar
  41. 41.
    Wei B, Yu J, Wang J, Li H, Yang L, Kong C (2017) Trace metals in the urine and hair of a population in an endemic arsenism area. Biol Trace Elem Res.  https://doi.org/10.1007/s12011-017-1108-x CrossRefPubMedGoogle Scholar
  42. 42.
    Jazestani M, Chiniforoshan H, Tabrizi L, McArdle P (2016) Synthesis and crystal structures of cobalt(II), cadmium(II), and zinc(II) complexes of 4-nitro phenylcyanamide: enhancing the biological properties through bound to human serum albumin. J Biomol Struct Dyn 16:1–11Google Scholar
  43. 43.
    Prozialeck WC, Edwards JR (2010) Early biomarkers of cadmium exposure and nephrotoxicity. Biometals 23(5):793–809.  https://doi.org/10.1007/s10534-010-9288-2 CrossRefPubMedGoogle Scholar
  44. 44.
    Lauwerys RR, Buchet JP, Roels H (1976) The relationship between cadmium exposure or body burden and the concentration of cadmium in blood and urine in man. Int Arch Occup Environ Health 36(4):275–285.  https://doi.org/10.1007/BF00409357 CrossRefPubMedGoogle Scholar
  45. 45.
    El-Agha O, Gökmen IG (2002) Smoking habits and cadmium intake in Turkey. Biol Trace Elem Res 88(1):31–43.  https://doi.org/10.1385/BTER:88:1:31 CrossRefPubMedGoogle Scholar
  46. 46.
    Kiziler AR, Aydemir B, Onaran I, Alici B, Ozkara H, Gulyasar T, Akyolcu MC (2007) High levels of cadmium and lead in seminal fluid and blood of smoking men are associated with high oxidative stress and damage in infertile subjects. Biol Trace Elem Res 120(1–3):82–91.  https://doi.org/10.1007/s12011-007-8020-8 CrossRefPubMedGoogle Scholar
  47. 47.
    Schöpfer J, Drasch G, Schrauzer GN (2010) Selenium and cadmium levels and ratios in prostates, livers, and kidneys of nonsmokers and smokers. Biol Trace Elem Res 134(2):180–187.  https://doi.org/10.1007/s12011-010-8636-y CrossRefPubMedGoogle Scholar
  48. 48.
    Wallin M, Sallsten G, Lundh T, Barregard L (2014) Low-level cadmium exposure and effects on kidney function. Occup Environ Med 71(12):848–854.  https://doi.org/10.1136/oemed-2014-102279 CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Stajnko A, Falnoga I, Tratnik JS, Mazej D, Jagodic M, Krsnik M, Kobal AB, Prezelj M, Kononenko L, Horvat M (2017) Low cadmium exposure in males and lactating females-estimation of biomarkers. Environ Res 152:109–119.  https://doi.org/10.1016/j.envres.2016.09.025 CrossRefPubMedGoogle Scholar
  50. 50.
    Buchet JP, Lauwerys R, Roels H, Bernard A, Bruaux P, Claeys F, Ducoffre G, de Plaen P, Staessen J, Amery A (1990) Renal effects of cadmium body burden of the general population. Lancet 336(8717):699–702.  https://doi.org/10.1016/0140-6736(90)92201-R CrossRefPubMedGoogle Scholar
  51. 51.
    Wu X, Jin T, Wang Z, Ye T, Kong Q, Nordberg G (2001) Urinary calcium as a biomarker of renal dysfunction in a general population exposed to cadmium. J Occup Environ Med 43(10):898–904.  https://doi.org/10.1097/00043764-200110000-00009 CrossRefPubMedGoogle Scholar
  52. 52.
    Hayashizaki J, Ban S, Nakagaki H, Okumura A, Yoshii S, Robinson C (2008) Site specific mineral composition and microstructure of human supra-gingiva dental calculus. Arch Oral Biol 53(2):168–174.  https://doi.org/10.1016/j.archoralbio.2007.09.003 CrossRefPubMedGoogle Scholar
  53. 53.
    Nancollas GH, Johnsson MAS (1994) Calculus formation and inhibition. Adv Dem Res 8(2):307–311.  https://doi.org/10.1177/08959374940080022601 CrossRefGoogle Scholar
  54. 54.
    Kodaka T, Ohohara Y, Debari K (1992) Scanning electron microscopy and energy dispersive x-ray microanalysis studies of early dental calculus on resin plates exposed to human oral cavities. Scanning Microsc 6:475–485PubMedGoogle Scholar
  55. 55.
    Mandel ID (1987) Calculus formation and prevention: an overview. Compend Suppl 8:S235–S241Google Scholar
  56. 56.
    Tan BT, Mordan NJ, Embleton J, Pratten J, Galgut PN (2004) Study of bacterial viability within human supragingival dental calculus. J Periodontol 75(1):23–29.  https://doi.org/10.1902/jop.2004.75.1.23 CrossRefPubMedGoogle Scholar
  57. 57.
    Metcalf JL, Ursell LK, Knight R (2014) Ancient human oral plaque preserves a wealth of biological data. Nat Genet 46(4):321–323.  https://doi.org/10.1038/ng.2930 CrossRefPubMedGoogle Scholar
  58. 58.
    Tsuda H, Arends J (1993) Raman spectra of human dental calculus. J Dent Res 72(12):1609–1613.  https://doi.org/10.1177/00220345930720121401 CrossRefPubMedGoogle Scholar
  59. 59.
    Nowak B, Kozlowski H (1998) Heavy metals in human hair and teeth -the correlation with metal concentration in the environment. Biol Trace Elem Res 62(3):213–228.  https://doi.org/10.1007/BF02783972 CrossRefPubMedGoogle Scholar
  60. 60.
    Abdazimov AD (1991) Changes in the trace clement composition of the hard dental tissues, dental calculus, saliva and gingival biopsies in workers under the influence of unfavorable factors in the manufacture of Cu, Zn and Pb. Stomatohgiia Mosk 70:22–25Google Scholar
  61. 61.
    Fischer A, Wiechuła D, Postek-Stefańska L, Kwapuliński J (2009) Concentrations of metals in maxilla and mandible deciduous and permanent human teeth. Biol Trace Elem Res 132(1–3):19–26.  https://doi.org/10.1007/s12011-009-8383-0 CrossRefPubMedGoogle Scholar
  62. 62.
    Barton HJ (2011) Advantages of the use of deciduous teeth, hair, and blood analysis for lead and cadmium bio-monitoring in children. A study of 6-year-old children from Krakow (Poland). Biol Trace Elem Res 143(2):637–658.  https://doi.org/10.1007/s12011-010-8896-6 PubMedCrossRefGoogle Scholar
  63. 63.
    Costa de Almeida GR, Pereira Saraiva Mda C, Barbosa F Jr, Krug FJ, Cury JA, Rosário de Sousa Mda L, Rabelo Buzalaf MA, Gerlach RF (2007) Lead contents in the surface enamel of deciduous teeth sampled in vivo from children in uncontaminated and in lead-contaminated areas. Environ Res 104(3):337–345.  https://doi.org/10.1016/j.envres.2007.03.007 CrossRefPubMedGoogle Scholar
  64. 64.
    Serdar MA, Akin BS, Razi C, Akin O, Tokgoz S, Kenar L, Aykut O (2012) The correlation between smoking status of family members and concentrations of toxic trace elements in the hair of children. Biol Trace Elem Res 148(1):11–17.  https://doi.org/10.1007/s12011-012-9337-5 CrossRefPubMedGoogle Scholar
  65. 65.
    Alomary A, Al-Momani IF, Massadeh AM (2006) Lead and cadmium in human teeth from Jordan by atomic absorption spectrometry: some factors influencing their concentrations. Sci Total Environ 369(1-3):69–75.  https://doi.org/10.1016/j.scitotenv.2006.04.023 CrossRefPubMedGoogle Scholar
  66. 66.
    Alhasmi AM, Gondal MA, Nasr MM, Shafik S, Habibullah YB (2015) Detection of toxic elements using laser-induced breakdown spectroscopy in smokers’ and nonsmokers’ teeth and investigation of periodontal parameters. Appl Opt 54(24):7342–7349.  https://doi.org/10.1364/AO.54.007342 CrossRefPubMedGoogle Scholar

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Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial SurgeryHunan Provincial People’s Hospital and The First Affiliated Hospital of Hunan Normal UniversityChangshaPeople’s Republic of China
  2. 2.Hanwoo DNA Solutions Co., LtdChangshaChina
  3. 3.Hunan Legal Forensic CenterChangshaChina

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