Biological Trace Element Research

, Volume 184, Issue 2, pp 334–339 | Cite as

Magnesium in Breast Cancer: What Is Its Influence on the Progression of This Disease?

  • Priscyla Maria Vieira Mendes
  • Daila Leite Chaves Bezerra
  • Loanne Rocha dos Santos
  • Raísa de Oliveira Santos
  • Stéfany Rodrigues de Sousa Melo
  • Jennifer Beatriz Silva Morais
  • Juliana Soares Severo
  • Sabas Carlos Vieira
  • Dilina do Nascimento Marreiro


Breast cancer is a disease of high mortality, characterized by the progressive accumulation of mutations that contribute to the uncontrolled development of breast tissue cells. Literature shows that disturbances in mineral homeostasis, such as magnesium, may interfere with tumor progression. The objective of this study is to provide updated information about magnesium’s role in the pathogenesis of breast cancer. A review of literature was carried out from a search for articles in the PubMed and CAPES Periodicals databases published between 1995 and 2016 with the cross-references of the descriptors “magnesium,” “breast neoplasms,” and “oxidative stress” and the corresponding words in Portuguese. We included studies on the metabolism and bioavailability of magnesium and studies related to breast cancer and excluded articles in which only the abstract was available, dissertations, theses, articles involving adjuvant and/or neoadjuvant therapies, and supplementation of minerals in breast cancer patients. Magnesium is a mineral that participates in the metabolism of various nutrients and nucleic acids. In the presence of breast cancer, neoplastic cells increase the expression of magnesium transport channels, which raises the intracellular concentration of the mineral, contributing to tumor growth through its function of increasing energy demand. The data obtained in this review illustrates the influence of magnesium on the progression of breast cancer. However, the existing data are scarce and inconsistent, which demonstrates a need for further studies on the subject with a goal to have better control of the disease.


Magnesium Breast cancer Breast neoplasms 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Priscyla Maria Vieira Mendes
    • 1
  • Daila Leite Chaves Bezerra
    • 1
  • Loanne Rocha dos Santos
    • 1
  • Raísa de Oliveira Santos
    • 1
  • Stéfany Rodrigues de Sousa Melo
    • 1
  • Jennifer Beatriz Silva Morais
    • 1
  • Juliana Soares Severo
    • 1
  • Sabas Carlos Vieira
    • 2
  • Dilina do Nascimento Marreiro
    • 1
  1. 1.Department of NutritionFederal University of PiauíTeresinaBrazil
  2. 2.Department of MedicineFederal University of PiauíTeresinaBrazil

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