Biological Trace Element Research

, Volume 184, Issue 1, pp 165–172 | Cite as

The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats

  • Selcen Cakir
  • Meryem Eren
  • Meryem Senturk
  • Zeynep Soyer Sarica


In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats. Sixty Wistar albino rats (200–250 g) were divided into six groups of ten. The groups received the following treatment: group 1, control group; group 2, 50 mg/kg (b.w.) i.p. STZ-induced diabetes; group 3, 5 mg/kg (b.w.) B; group 4, 10 mg/kg (b.w.) B; group 5, diabetes + 5 mg/kg (b.w.) B; and group 6, diabetes + 10 mg/kg (b.w.) B. The experiment lasted 4 weeks. Increased serum MDA levels with diabetes were significantly reduced and although it is not statistically significant, serum TAC levels approached to values of control group; also, insignificant increases were observed in HDL cholesterol levels in experimental diabetic rats with treatment 5 and 10 mg/kg B. Furthermore, body weight, plasma insulin, and lipase activities increased insignificantly, blood glucose and serum LDL cholesterol decreased significantly, and total cholesterol levels decreased insignificantly in the diabetes + 10 mg/kg B group. There was no difference between the groups in terms of plasma PON1 activities and serum triglyceride levels. In conclusion, B may have beneficial effects on some biochemical parameters changes in experimental diabetes, and in order to determine the full effect of this element on the metabolism, further studies are required which use various dosages and compounds of B.


Biochemical parameters Body weight Boron Diabetes Rat 



This research was summarized from PhD thesis entitled “The Effect of Boron on Some Biochemical Parameters in Experimental Diabetic Rats” and supported by Erciyes University Research Fund. Project No. TSD-12-4027.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.High School of Physical Education and SportUniversity of BingölBingölTurkey
  2. 2.Faculty of Veterinary Medicine, Department of BiochemistryUniversity of ErciyesKayseriTurkey
  3. 3.Hakan Çetinsaya Experimental Animal CenterUniversity of ErciyesKayseriTurkey

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