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Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis

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Abstract

Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = −4.86, 95% CI −6.03–3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42–0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50–4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

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Authors and Affiliations

  1. Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China

    Du He, Zaiping Wang, Chuying Huang, Xiping Fang & Dian Chen

  2. Enshi Clinical College of Wuhan University, Enshi, China

    Du He, Zaiping Wang, Chuying Huang, Xiping Fang & Dian Chen

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  1. Du He
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  2. Zaiping Wang
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  3. Chuying Huang
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  5. Dian Chen
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Correspondence to Dian Chen.

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The authors declare that they have no conflict of interest.

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Du He and Zaiping Wang contributed equally to this study.

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He, D., Wang, Z., Huang, C. et al. Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis. Biol Trace Elem Res 179, 195–202 (2017). https://doi.org/10.1007/s12011-017-0982-6

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  • DOI: https://doi.org/10.1007/s12011-017-0982-6

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