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Biological Trace Element Research

, Volume 179, Issue 2, pp 195–202 | Cite as

Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis

  • Du He
  • Zaiping Wang
  • Chuying Huang
  • Xiping Fang
  • Dian ChenEmail author
Article

Abstract

Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = −4.86, 95% CI −6.03–3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42–0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50–4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

Keywords

Selenium Serum Cervical cancer Meta-analysis 

Notes

Compliance with Ethical Standards

Funding

None.

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12011_2017_982_MOESM1_ESM.doc (61 kb)
ESM 1 (DOC 60 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Du He
    • 1
    • 2
  • Zaiping Wang
    • 1
    • 2
  • Chuying Huang
    • 1
    • 2
  • Xiping Fang
    • 1
    • 2
  • Dian Chen
    • 1
    • 2
    Email author
  1. 1.Department of Oncology, The Central Hospital of Enshi Autonomous of PrefectureEnshi Clinical College of Wuhan UniversityEnshiChina
  2. 2.Enshi Clinical College of Wuhan UniversityEnshiChina

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