Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride
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Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received normal drinking water alone, group II rats were exposed to sodium fluoride (NaF) in drinking water at 15 mg/L alone, group III received taurine alone at a dose of 200 mg/kg group IV rats were co-administered with NaF and taurine (100 mg/kg), while group V rats were co-administered with NaF and taurine (200 mg/kg). Administration of taurine significantly reversed the fluoride-mediated decrease in absolute weight and organo-somatic index of the kidney in the exposed rats. Taurine significantly prevented fluoride-induced elevation in plasma urea and creatinine levels in the exposed rats. Moreover, taurine restored fluoride-mediated decrease in the circulatory concentrations of triiodothyronine, thyroxine, and the ratio of triiodothyronine to thyroxine. Taurine ameliorated fluoride-mediated decrease in renal antioxidant status by significantly enhancing the antioxidant enzyme activities as well as glutathione level in the exposed rats. Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats. Collectively, taurine protected against fluoride-induced renal toxicity via enhancement of thyroid gland function, renal antioxidant status, and histology in rats.
KeywordsFluoride Taurine Renal toxicity Thyroid hormones Rats
This research was done without specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
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Conflict of Interest
The authors declare that there are no conflicts of interest.
- 2.USNRC (1993) Health effects of ingested fluoride. National Research Council, National Academy Press, Washington D.CGoogle Scholar
- 3.World Health Organization (2004). Guidelines for Drinking-water Quality (GDWQ). WHO/SDE/WSH/03.04/96. Pp 1–17.Google Scholar
- 4.Cao SR (1992) Study on preventive and control measures on coal-combustion type endemic fluorosis in the three gorges area in China. (proceedings of the fourth National Academic Conference on endemic fluorosis. Chin J Endemic Die II(Suppl):6–21Google Scholar
- 5.World Health Organization (2002) Fluorides. World Health Organization, GenevaGoogle Scholar
- 6.Ding JP, Mao JQ, Gu SY (1998) Fluoride contamination and its control of lava groundwater in Guiyang dam area. Environ Protect Sci Technol 3:14–15Google Scholar
- 7.Wu GJ, Xu BF, Lu L (2006) Comment on fluorine pollution and prevention of Shilongba hydro-electric power station. J Kunming Univ Sci Technol 31:55–58Google Scholar
- 8.Saralakumari D, Ramakrishna RP (1993) Endemic fluorosis in the village Ralla Anantapuram in Andhra Pradesh: an epidemiological study. Fluoride 26:177Google Scholar
- 10.Shashi A, Singh JP, Thapar SP (2002) Toxic effects of fluoride on rabbit kidney. Fluoride 35:38–50Google Scholar
- 11.Liu GY, Chai CHY, Kang SHL (2002) Effects of fluoride on the ultrastructure of thyroid in chicks. Chin J Vet Sci 22:512–514Google Scholar
- 12.VV P, VT D (2015) Exposure to sodium fluoride affects thyroid follicular cells in albino rats. Int J Plant, Animal and Environ Sci 5l:56–61Google Scholar
- 28.Clairborne A (1995) Catalase activity. In: Greewald AR (ed) Handbook of methods for oxygen radical research. CRC Press, Boca Raton, FL, pp. 237–242Google Scholar
- 31.Bancroft JD. Gamble M. (2008). Theory and practice of histology techniques, 6th edition. Churchill Livingstone Elsevier, Pp 83–134.Google Scholar
- 38.Zhan XA, Wang M, Xu ZR, Li JX (2006) Toxic effects of fluoride on kidney function and histology in young pigs. Fluoride 39:22–26Google Scholar
- 39.Podder S, Chattopadhyay A, Bhattacharya S (2008) In vivo suppression by fluoride of chromosome aberrations induced by mitomycin-c in mouse bone marrow cells. Fluoride 41:40–43Google Scholar
- 40.Podder S, Chattopadhyay A, Bhattacharya S, Ray MR (2008) Differential in vivo genotoxic effect of lower and higher concentrations of fluoride in mouse bone marrow cells. Fluoride 41:301–307Google Scholar