Biological Trace Element Research

, Volume 170, Issue 2, pp 288–293 | Cite as

Effects of Imbalance in Trace Element on Thyroid Gland from Moroccan Children

  • Sana El-Fadeli
  • Sabir Bouhouch
  • Anatoly V. Skalny
  • Yassir Barkouch
  • Alain Pineau
  • Mohamed Cherkaoui
  • Azeddine Sedki


The major environmental factor that determines goiter prevalence is iodine status. However, other trace elements like selenium and zinc can influence the thyroid function. Hair samples (n = 68) were collected from goitrous and non-goitrous children aged 8–12 years living in the area of Al Haouz Marrakech-(Morocco). Trace element concentrations (Cr, Fe, Mg, Zn, Se, I) in hair were measured using flame atomic absorption spectroscopy, graphite furnace atomic absorption spectroscopy, and inductively coupled plasma mass spectrometry. Difference in the mean concentration of each trace element between groups was determined by ANOVA test. The mean concentration levels of I, Se, and Zn for goitrous children were lower and were similar to the mean concentrations reported in the literature for subjects with goiter. The regression results gave us a better model that revealed significant positive relations between thyroid volume and Zn contents and significant negative relation with I and Se. The overall findings of the present study revealed that the actual factors of thyroid gland volume increase are I and Se deficiency. This work could shed some light on the effects of trace elements—other than iodine—on the thyroid disorders.


Trace elements Goitrous children Iodine Selenium Zinc 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Sana El-Fadeli
    • 1
  • Sabir Bouhouch
    • 2
  • Anatoly V. Skalny
    • 3
    • 4
  • Yassir Barkouch
    • 5
  • Alain Pineau
    • 6
  • Mohamed Cherkaoui
    • 2
  • Azeddine Sedki
    • 1
  1. 1.Laboratory of Hydrobiology, Ecotoxicology and SanitationMarrakechMorocco
  2. 2.Laboratory of Human EcologyMarrakechMorocco
  3. 3.P.G.Demidov Yaroslavl State UniversityYaroslavlRussia
  4. 4.Trace Element – Insitute for UNESCOLyonFrance
  5. 5.Regional Laboratory of Epidemiological Diagnosis and Environmental HealthMarrakechMorocco
  6. 6.Laboratory of Toxicology and Industrial HygieneNantesFrance

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