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Biological Trace Element Research

, Volume 170, Issue 1, pp 84–93 | Cite as

Natural Antioxidants Against Arsenic-Induced Genotoxicity

  • Munesh Kumar
  • Minakshi Lalit
  • Rajesh ThakurEmail author
Article

Abstract

Arsenic is present in water, soil, and air in organic as well as in inorganic forms. However, inorganic arsenic is more toxic than organic and can cause many diseases including cancers in humans. Its genotoxic effect is considered as one of its carcinogenic actions. Arsenic can cause DNA strand breaks, deletion mutations, micronuclei formation, DNA-protein cross-linking, sister chromatid exchange, and DNA repair inhibition. Evidences indicate that arsenic causes DNA damage by generation of reactive free radicals. Nutritional supplementation of antioxidants has been proven highly beneficial against arsenic genotoxicity in experimental animals. Recent studies suggest that antioxidants protect mainly by reducing excess free radicals via restoring the activities of cellular enzymatic as well as non-enzymatic antioxidants and decreasing the oxidation processes such as lipid peroxidation and protein oxidation. The purpose of this review is to summarize the recent literature on arsenic-induced genotoxicity and its mitigation by naturally derived antioxidants in various biological systems.

Keywords

Genotoxicity Antioxidants Oxidative stress Free radicals Inorganic arsenic 

Abbreviations

NRC

National Research Council

ROS

Reactive oxygen species

SOD

Superoxide dismutase

CAT

Catalase

GSH

Glutathione

ALAD

δ-Aminolevulinic acid dehydratase

DMSA

Meso-2,3-dimercaptosuccinic acid

δ-ALA

δ-Aminolevulinic acid

GPx

Glutathione peroxidase

SAM

S-Adenosyl methionine

MDA

Malondialdehyde

XO

Xanthine oxidase

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no competing interests.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Guru Jambhehswar University of Science and TechnologyHisarIndia

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