Biological Trace Element Research

, Volume 169, Issue 2, pp 159–163

Trace Element Changes in Thoracic Aortic Dissection

  • Marie Edvinsson
  • Nils-Gunnar Ilbäck
  • Peter Frisk
  • Stefan Thelin
  • Christina Nyström-Rosander
Article

Abstract

Thoracic aortic dissection is a life-threatening condition with an incompletely understood pathogenesis. Trace elements are essential for the functioning of different processes in the body, including the immune system and associated responses to infection/inflammation. Because inflammation may be part of the pathogenesis of thoracic aortic dissection, we investigated whether trace element changes associated with inflammation occur in serum and tissue samples during the disease. The study included 21 patients undergoing surgery for thoracic aortic dissection, 10 forensic autopsy specimens for tissue controls and 23 healthy blood donors for serum controls. Levels of magnesium (Mg), calcium (Ca), vanadium (V), manganese (Mn), iron (Fe), cobalt (Co), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd) and mercury (Hg) were measured in the aortic tissue and serum by inductively coupled plasma-mass spectrometry (ICP-MS). In the serum, Ca, V, Cu and Zn decreased, whereas Fe increased. In the tissue, Cu and Zn decreased and Fe tended to increase. The Cu/Zn ratio in the serum, a marker of infection/inflammation, did not change in the patients. Concerning trace element changes in the serum and tissue, our data do not support the hypothesis that inflammation is involved in the pathogenesis of thoracic aortic dissection.

Keywords

Aortic dissection Inflammation Copper Zinc Iron 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Marie Edvinsson
    • 1
  • Nils-Gunnar Ilbäck
    • 1
    • 4
  • Peter Frisk
    • 3
  • Stefan Thelin
    • 2
  • Christina Nyström-Rosander
    • 1
  1. 1.Department of Medical Sciences, Infectious DiseasesUppsala University, University HospitalUppsalaSweden
  2. 2.Department of Surgical Sciences, Thoracic SurgeryUppsala UniversityUppsalaSweden
  3. 3.Research in Metal Biology, Rudbeck LaboratoryUppsala UniversityUppsalaSweden
  4. 4.Risk Benefit Assessment DepartmentNational Food AgencyUppsalaSweden

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