Biological Trace Element Research

, Volume 168, Issue 1, pp 11–14 | Cite as

Moderately High Dose Zinc Gluconate or Zinc Glycinate: Effects on Plasma Zinc and Erythrocyte Superoxide Dismutase Activities in Young Adult Women

  • Robert A. DiSilvestroEmail author
  • Erin Koch
  • Linda Rakes


Some zinc (Zn) research studies have used either Zn gluconate or Zn glycinate, but the two forms have not been compared much. Therefore, a moderately high dose of the two forms (60 mg Zn/day) were compared in a 6-week intervention in young adult women. Plasma Zn, the traditional assessment of Zn status, was increased in all subjects given Zn glycinate (N = 10), while no significant change was seen overall for Zn gluconate or placebo (N = 10 each). Erythrocyte superoxide dismutase activity, a marker for Zn-induced copper deficiency, was unchanged in all three groups. Thus, for the conditions of this study, Zn glycinate effectively changed Zn status better than Zn gluconate, but neither impacted copper status.


Zinc Chelates Gluconate Glycinate Superoxide dismutase Supplementation 


Conflict of Interest

R. DiSilvestro is currently using zinc glycinate in products affiliated with his startup company, but that was not the case at the time the study was done (which was over 12 years ago).


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Robert A. DiSilvestro
    • 1
    Email author
  • Erin Koch
    • 1
  • Linda Rakes
    • 1
  1. 1.Human NutritionOhio State UniversityColumbusUSA

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