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Biological Trace Element Research

, Volume 158, Issue 1, pp 105–112 | Cite as

Brazil Nut (Bertholletia excelsa, H.B.K.) Improves Oxidative Stress and Inflammation Biomarkers in Hemodialysis Patients

  • Milena Barcza Stockler-Pinto
  • Denise Mafra
  • Cristiane Moraes
  • Julie Lobo
  • Gilson Teles Boaventura
  • Najla Elias Farage
  • Wellington Seguins Silva
  • Silvia Franciscato Cozzolino
  • Olaf Malm
Article

Abstract

Cumulative evidence indicates that oxidative stress and inflammation frequently occurs in patients undergoing maintenance hemodialysis (HD) and as a result of overproduction of reactive oxygen species (ROS) and a decrease of antioxidant defenses such as selenium (Se). Previous studies in our laboratory showed that the supplementation of 1 unit of Brazil nut (the richest known food source of Se) a day during 3 months is effective to improve Se status and increase glutathione peroxidase (GPx) levels in HD patients. The aim of this study was to evaluate the effect of Brazil nut supplementation on oxidative stress and inflammation markers in HD patients. Forty HD patients from Rio de Janeiro, Brazil were studied. All patients received one nut per day for 3 months. The Se plasma levels and GPx, 8-isoprostane, 8-hydroxy-2-deoxyguanosine (8-OHdG), and cytokine (TNF-α and IL-6) levels and lipid profile were determined before and after 3 months of supplementation. The plasma Se and GPx activity increased, while cytokines, 8-OHdG, and 8-isoprostane plasma levels decreased significantly after 3 months supplementation. HDL-c levels increased and LDL-c levels decreased significantly. These data suggest that the consumption of only one Brazil nut per day during 3 months was effective to reduce the inflammation, oxidative stress markers, and the atherogenic risk, thereby increasing the antioxidant defenses in HD patients. Our results indicate that Brazil nut as Se source plays an important role as an anti-inflammatory and antioxidant agent in HD patients.

Keywords

Selenium Chronic kidney disease Hemodialysis Oxidative stress and inflammation 

Notes

Acknowledgments

We wish to thank the Clinic RenalCor, Rio de Janeiro, for allowing their patients to participate in this study. This study was supported by FAPERJ (Foundation for Research of the state of Rio de Janeiro) and as well as by the Brazilian National Council for Scientific and Technological Development (CNPq).

Conflict of Interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Milena Barcza Stockler-Pinto
    • 1
    • 8
  • Denise Mafra
    • 2
    • 4
  • Cristiane Moraes
    • 2
  • Julie Lobo
    • 3
  • Gilson Teles Boaventura
    • 4
  • Najla Elias Farage
    • 5
  • Wellington Seguins Silva
    • 6
  • Silvia Franciscato Cozzolino
    • 7
  • Olaf Malm
    • 1
  1. 1.Carlos Chagas Filho Biophysics Institute, Health Sciences CentreFederal University of Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  2. 2.Cardiovascular Sciences Graduate ProgramFederal University Fluminense (UFF)NiteróiBrazil
  3. 3.Post Graduation of Science Applied to Musculosketetal SystemNational Institute of Traumatology and Orthopedics (INTO)Rio de JaneiroBrazil
  4. 4.Medical Sciences Graduate ProgramFederal University Fluminense (UFF)NiteróiBrazil
  5. 5.RenalCor ClinicRio de JaneiroBrazil
  6. 6.Oswaldo Cruz Foundation (FIOCRUZ)Rio de JaneiroBrazil
  7. 7.Faculty of Pharmaceutical SciencesUniversity of São PauloSão PauloBrazil
  8. 8.Laboratório de Radioisótopos Eduardo Penna FrancaRio de JaneiroBrazil

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