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Biological Trace Element Research

, Volume 165, Issue 1, pp 59–66 | Cite as

Influence of Dietary Zinc and Copper on Apparent Mineral Retention and Serum Biochemical Indicators in Young Male Mink (Mustela vison)

  • Xuezhuang Wu
  • Zhi Liu
  • Jungang Guo
  • Chunmeng Wan
  • Tietao Zhang
  • Hu Cui
  • Fuhe Yang
  • Xiuhua Gao
Article

Abstract

An experiment was conducted in a 3 × 3 (Cu × Zn) factorial experiment based on a completely randomized design to evaluate the effects of dietary copper and zinc on apparent mineral retention and serum biochemical indicators in young male mink on a corn-fish meal based diet. Animals were fed basal diets supplemented with Cu from copper sulfate (CuSO4) and Zn from zinc sulfate (ZnSO4). Supplemental Cu levels were 0, 15, and 30 mg/kg copper, respectively, while supplemental Zn levels were 0, 150, and 300 mg/kg, respectively. A metabolism trial of 4 days was conducted during the last week of experimental feeding. Blood samples were collected via the toe clip to determine blood hematology and blood metabolites. Copper excretion, retention, and digestibility were influenced by dietary copper (P < 0.05), however, there was also a zinc-copper interaction. Copper digestibility and retention were substantially reduced when zinc was added to the low copper diet but showed little change with zinc supplementation of the high copper diet. Both plasma Cu and plasma Zn were influenced by dietary level of the respective mineral (P < 0.05). There was no influence of dietary copper on plasma zinc; however, high Zn in the diet reduced plasma Cu concentrations. There was a zinc-copper interaction for plasma Cu (P = 0.053). Cu-Zn superoxide dismutase (Cu-Zn SOD) activity tended to be influenced by dietary zinc (P = 0.065) and dietary copper (P = 0.035). Dietary copper had a significant effect on ceruloplasmin (CER) and triglyceride (TG) concentrations (P < 0.05). Our results show that moderately high Zn in the diet (Zn:Cu ratio of 40:1) significantly reduce the apparent Cu digestibility. Our results also show that moderately high Cu in the diet increases Cu retention, but not reduces Zn absorption, and moderately high Zn in the diet reduced plasma Cu concentrations and CER activity.

Keywords

Mink Copper Zinc Interaction Serum biochemical indicators 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Xuezhuang Wu
    • 1
    • 2
  • Zhi Liu
    • 1
  • Jungang Guo
    • 1
  • Chunmeng Wan
    • 1
  • Tietao Zhang
    • 2
  • Hu Cui
    • 1
  • Fuhe Yang
    • 2
  • Xiuhua Gao
    • 1
  1. 1.Feed Research InstituteChinese Academy of Agricultural SciencesBeijingChina
  2. 2.State Key Laboratory for Molecular Biology of Special Economic AnimalsInstitute of Economic Animal and Plant Science, CAASChangchunChina

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