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Biological Trace Element Research

, Volume 164, Issue 2, pp 198–204 | Cite as

A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz: Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line

  • Ignacio E. León
  • Beatriz S. Parajón-Costa
  • Carlos A. Franca
  • Susana B. Etcheverry
  • Enrique J. BaranEmail author
Article

Abstract

The oxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H2O could be synthesized for the first time by reaction between [VO(ODA)(H2O)2] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H2O complex.

Keywords

Oxidovanadium(IV) Oxodiacetic acid dppz DFT calculations FTIR spectrum Electronic spectrum Human osteosarcoma cell line 

Notes

Acknowledgments

This research was supported by the Universidad Nacional de La Plata, the Agencia Nacional de Promoción Científica y Tecnológica-ANPCyT (PICT 2218), and the Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET (PIP 1125 and PIP 5078). The authors are indebted to Dr. J. Zinczuk, Instituto de Química de Rosario (IQUIR/CONICET,UNR), Rosario, Argentina, for the synthesis of dppz. IEL is a fellow from CONICET and BSPC, and SBE are members of the Research Career from CONICET. CAF acknowledges the Universidad Nacional de Catamarca for computing time.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ignacio E. León
    • 1
    • 2
  • Beatriz S. Parajón-Costa
    • 2
  • Carlos A. Franca
    • 2
  • Susana B. Etcheverry
    • 1
    • 2
  • Enrique J. Baran
    • 2
    Email author
  1. 1.Cátedra de Bioquímica Patológica, Facultad de Ciencias ExactasUniversidad Nacional de La PlataLa PlataArgentina
  2. 2.Centro de Química Inorgánica (CEQUINOR/CONICET, UNLP), Facultad de Ciencias ExactasUniversidad Nacional de La PlataLa PlataArgentina

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