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Biological Trace Element Research

, Volume 160, Issue 3, pp 321–339 | Cite as

Hepatic Transcriptome Profiles Differ Among Maturing Beef Heifers Supplemented with Inorganic, Organic, or Mixed (50 % Inorganic:50 % Organic) Forms of Dietary Selenium

  • James C. Matthews
  • Zhi Zhang
  • Jennifer D. Patterson
  • Phillip J. Bridges
  • Arnold J. Stromberg
  • J. A. Boling
Article

Abstract

Selenium (Se) is an important trace mineral that, due to deficiencies in the soil in many parts of the USA, must be supplemented directly to the diet of foraging cattle. Both organic and inorganic forms of dietary Se supplements are available and commonly used, and it is known that Se form affects tissue assimilation, bioavailability, and physiological responses. However, little is known about the effects of form of dietary Se supplements on gene expression profiles, which ostensibly account for Se form-dependent physiological processes. To determine if hepatic transcriptomes of growing beef (Angus-cross) heifers (0.5 kg gain/day) was altered by form of dietary supplemental Se, none (Control), or 3 mg Se/day as inorganic Se (ISe, sodium selenite), organic (OSe, Sel-Plex®), or a blend of ISe and OSe (1.5 mg:1.5 mg, Mix) Se was fed for 168 days, and the RNA expression profiles from biopsied liver tissues was compared by microarray analysis. The relative abundance of 139 RNA transcripts was affected by Se treatment, with 86 of these with complete gene annotations. Statistical and bioinformatic analysis of the annotated RNA transcripts revealed clear differences among the four Se treatment groups in their hepatic expression profiles, including (1) solely and commonly affected transcripts; (2) Control and OSe profiles being more similar than Mix and ISe treatments; (3) distinct OSe-, Mix-, and ISe-Se treatment-induced “phenotypes” that possessed both common and unique predicted physiological capacities; and (4) expression of three microRNAs were uniquely sensitive to OSe, ISe, or Mix treatments, including increased capacity for redox potential induced by OSe and Mix Se treatments resulting from decreased expression of MiR2300b messenger RNA. These findings indicate that the form of supplemental dietary Se consumed by cattle will affect the composition of liver transcriptomes resulting, presumably, in different physiological capacities.

Keywords

Bovine Liver Microarray MicroRNA Nutrient-gene interaction Selenium supplementation 

Abbreviations

ANOVA

Analysis of variance

BOLA-DQA2

Bos taurus major histocompatibility complex, class II, DQ alpha 2

DEG

Differentially expressed gene

DDHD1

Phosphatidic acid-prefering phospholipase A1

GHRH

Growth hormone-releasing hormone

GPX1

Cellular glutathione peroxidase-1

ISe

Inorganic selenium

miRNA

microRNA

mRNA

Messenger RNA

Mix

50:50 ISe:OSe

OSe

Organic selenium

QPCT

Glutaminyl-peptide cyclotransferease

Se

Selenium

SeCys

Selenocysteine

SeMet

Selenomethionine

SEPW

Selenoprotein W

Notes

Acknowledgments

This research was supported by the Alltech-University of Kentucky Animal Nutrigenomics Alliance (JCM), University of Kentucky, and Kentucky Agricultural Experiment Station. The information reported in this paper (publication no. 14-07-038) is part of a project of the Kentucky Agricultural Experiment Station and is published with approval of the Director.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • James C. Matthews
    • 1
  • Zhi Zhang
    • 1
  • Jennifer D. Patterson
    • 1
  • Phillip J. Bridges
    • 1
  • Arnold J. Stromberg
    • 2
  • J. A. Boling
    • 1
  1. 1.Department of Animal and Food SciencesUniversity of KentuckyLexingtonUSA
  2. 2.Department of StatisticsUniversity of KentuckyLexingtonUSA

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