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Biological Trace Element Research

, Volume 160, Issue 2, pp 155–160 | Cite as

Antioxidant Status in Blood of Obese Children: The Relation between Trace Elements, Paraoxonase, and Arylesterase Values

  • Yasemin Cayir
  • Atilla CayirEmail author
  • Mehmet Ibrahim Turan
  • Nezahat Kurt
  • Mustafa Kara
  • Esra Laloglu
  • Murat Ciftel
  • Abdulkadir Yildirim
Article

Abstract

Obesity is known to lead to complications involving several systems. The basic mechanism in obesity-related complications is chronic inflammation and increased oxidative stress. Trace element levels in obese children may vary due to poor nutritional habits. The purpose of this study was to investigate the relation between serum paraoxonase (PON1) and arylesterase (ARE) levels, markers of the oxidant–antioxidant balance in the body, and serum zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) concentrations in obese children. Fifty-seven overweight patients aged 6–17 and 48 age- and sex-matched healthy children were included in the study. Serum PON1 and ARE activity levels were measured, together with Cu, Zn, Mn, Se, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, glucose, aspartate amino transferase, and alanine amino transferase levels. PON1 and ARE activity levels were significantly lower in obese patients compared to those in healthy individuals (P < 0.05). Various changes were determined in Cu, Zn, Mn, and Se levels between the study and control groups (P < 0.05). In terms of the relation between trace elements and PON1 and ARE levels, a significant positive correlation was determined between serum Se and PON1 levels in the study group (P < 0.05, r = 0.31). No significant correlation was determined between other trace element levels and PON1 and ARE levels (P > 0.05). In conclusion, the detection in our study of a positive correlation between Se and PON1 levels in obese children may be significant in terms of showing a relation between Se and antioxidant systems in obese children.

Keywords

Trace elements Paraoxonase Arylesterase Obesity Child 

Notes

Conflict of Interest

All authors declare that they have no conflicts of interest.

Financial Disclosure

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Yasemin Cayir
    • 1
  • Atilla Cayir
    • 2
    Email author
  • Mehmet Ibrahim Turan
    • 3
  • Nezahat Kurt
    • 4
  • Mustafa Kara
    • 5
  • Esra Laloglu
    • 4
  • Murat Ciftel
    • 2
  • Abdulkadir Yildirim
    • 4
  1. 1.Faculty of Medicine, Department of Family MedicineAtaturk UniversityErzurumTurkey
  2. 2.Departments of Pediatric EndocrinologyRegional Training and Research HospitalErzurumTurkey
  3. 3.Departments of PediatricsRegional Training and Research HospitalDiyarbakirTurkey
  4. 4.Faculty of Medicine, Department of BiochemistryAtaturk UniversityErzurumTurkey
  5. 5.Faculty of Medicine, Department of PediatricsAtaturk UniversityErzurumTurkey

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