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Biological Trace Element Research

, Volume 156, Issue 1–3, pp 56–66 | Cite as

Relationship between Dietary Magnesium, Manganese, and Copper and Metabolic Syndrome Risk in Korean Adults: The Korea National Health and Nutrition Examination Survey (2007–2008)

  • Mi-Kyeong Choi
  • Yun-Jung Bae
Article

Abstract

Recent studies have reported correlations between mineral intake and metabolic syndrome (MS), but accurate relationships and consistency in the results are difficult to confirm. Accordingly, this study aims to assess the dietary intakes of magnesium (Mg), manganese (Mn), and copper (Cu) to determine their relationship with MS. Data from a total of 5,136 adults (2,084 men, 3,052 women) was collected from the 2007–2008 Korea National Health and Nutrition Examination Survey (KNHANES), and the intakes of Mg, Mn, and Cu of the MS patients were compared with those of healthy adults. The relationship between the intakes of these minerals and the MS risks was analyzed. Diagnosis of MS was evaluated by the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) standards. Among all study subjects, 25.9 % (540 subjects) of the men and 24.5 % (748 subjects) of the women met diagnostic criteria for inclusion in the MS group. In the men, daily intakes of Mg and Cu in the MS group were significantly lower than those in control group, and in the women, daily intakes of energy, Mg, Mn, and Cu in the MS group were significantly lower than those of the control group. The women subjects with high blood pressure showed significantly lower intakes of Mg, Mn, and Cu than control subjects. In addition, in the women, the highest quartile of Mg and Cu was inversely associated with MS, but with adjustment were not maintained. However, in the postmenopausal women, MS was significant and inversely associated with the highest quartiles of Cu intake and the association remained significant after adjustments. Considering that MS incidence increases and dietary intake and nutrient density decrease with increasing age, and mineral intake is reduced accordingly, these results suggest that meal management with adequate mineral intake is advisable to control MS.

Keywords

Dietary intake Magnesium Manganese Copper Metabolic syndrome Korean adults 

References

  1. 1.
    Grundy SM (2006) Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol 47:1093–1100PubMedCrossRefGoogle Scholar
  2. 2.
    Alberti KG, Zimmet PZ (1998) Definition diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med 15:539–553PubMedCrossRefGoogle Scholar
  3. 3.
    Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRefGoogle Scholar
  4. 4.
    Ford ES, Giles WJ, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey. JAMA 287:356–359PubMedCrossRefGoogle Scholar
  5. 5.
    Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709–2716PubMedCrossRefGoogle Scholar
  6. 6.
    Park HS, Oh SW, Cho SI, Choi WH, Kim YS (2004) The metabolic syndrome and associated lifestyle factors among South Korean adults. Int J Epidemiol 33:328–336PubMedCrossRefGoogle Scholar
  7. 7.
    Lim S, Shin H, Song JH, Kwak SH, Kang SM, Yoon JW, Choi SH, Cho SI, Park KS, Lee HK, Jang HC, Koh KK (2011) Increasing prevalence of metabolic syndrome in Korea. Diabetes Care 34:1323–1328PubMedCrossRefGoogle Scholar
  8. 8.
    Day C (2007) Metabolic syndrome, or what you will: definitions and epidemiology. Diab Vasc Dis Res 4:32–38PubMedCrossRefGoogle Scholar
  9. 9.
    Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC (2006) Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. Am J Clin Nutr 84:1489–1497PubMedGoogle Scholar
  10. 10.
    Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC (2007) Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome. Am J Clin Nutr 85:910–918PubMedGoogle Scholar
  11. 11.
    Lutsey PL, Steffen LM, Stevens J (2008) Dietary intake and the development of the metabolic syndrome: the atherosclerosis risk in communities study. Circulation 117:754–761PubMedCrossRefGoogle Scholar
  12. 12.
    Wester PO (1987) Magnesium. Am J Clin Nutr 45:1305–1312PubMedGoogle Scholar
  13. 13.
    Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa A, Pineo A, Busardo A, Paolisso G (2003) Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 24:39–52PubMedCrossRefGoogle Scholar
  14. 14.
    Kawano Y, Matsuoka H, Takishita S, Omae T (1998) Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures. Hypertension 32:260–265PubMedCrossRefGoogle Scholar
  15. 15.
    Singh RB, Rastogi SS, Mani UV, Seth J, Devi L (1991) Does dietary magnesium modulate blood lipids? Biol Trace Elem Res 30:59–64PubMedCrossRefGoogle Scholar
  16. 16.
    Roberts CK, Sindhu KK (2009) Oxidative stress and metabolic syndrome. Life Sci 84:705–712PubMedCrossRefGoogle Scholar
  17. 17.
    Zhang Y, Zhang HM, Shi Y, Lustgarten M, Li Y, Qi W, Zhang BX, Van Remmen H (2010) Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts. Free Radic Biol Med 49:1255–1262PubMedCrossRefGoogle Scholar
  18. 18.
    Uauy R, Olivares M, Gonzalez M (1998) Essentiality of copper in humans. Am J Clin Nutr 67S:952S–959SGoogle Scholar
  19. 19.
    Bo S, Durazzo M, Gambino R, Berutti C, Milanesio N, Caropreso A, Gentile L, Cassader M, Cavallo-Perin P, Pagano G (2008) Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults. J Nutr 138:305–310PubMedGoogle Scholar
  20. 20.
    The Ministry of Health and Welfare, Korean Center for Disease Control and Prevention (2009) National health statistics. Korea Center for Disease Control and. Prevention, SeoulGoogle Scholar
  21. 21.
    Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752PubMedCrossRefGoogle Scholar
  22. 22.
    Lee SY, Kim SM, Kwon HS, Kim DY, Kim DJ, Cho GJ, Han JH, Kim SR, Park CY, Oh SJ (2006) Cut-off points of waist circumference for defining abdominal obesity in the Korean population. Kor Soc Stud Obes 15:1–9Google Scholar
  23. 23.
    Bae YJ, Kim MH, Choi MK (2010) Analysis of magnesium contents in commonly consumed foods and evaluation of its daily intake in Korean independent-living subjects. Biol Trace Elem Res 135:182–199PubMedCrossRefGoogle Scholar
  24. 24.
    Choi MK, Kim EY (2007) Analysis of manganese content in frequently consumed foods by Koreans. Korean J Nutr 40:769–778Google Scholar
  25. 25.
    Institute National Rural Resources Development, Administration RD (2006) Food composition tables, 7th edn. Hyoil, SeoulGoogle Scholar
  26. 26.
    The Korean Nutrition Society (2010) Dietary Reference Intakes for Koreans. The Korean Nutrition Society, SeoulGoogle Scholar
  27. 27.
    Yang YJ, Kim YJ, Yang YK, Kim JY, Kwon O (2012) Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults. Nutr Res Pract 6:68–77PubMedCrossRefGoogle Scholar
  28. 28.
    Buscemi S, Verga S, Donatelli M, D'Orio L, Mattina A, Tranchina MR, Pizzo G, Mulè G, Cerasola G (2009) A low reported energy intake is associated with metabolic syndrome. J Endocrinol Invest 32:538–541PubMedGoogle Scholar
  29. 29.
    Bandini LG, Schoeller DA, Cyr HN, Dietz WH (1990) Validity of reported energy intake in obese and nonobese adolescents. Am J Clin Nutr 52:421–425PubMedGoogle Scholar
  30. 30.
    Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240–1243PubMedCrossRefGoogle Scholar
  31. 31.
    Livingstone MB, Black AE (2003) Markers of the validity of reported energy intake. J Nutr 133(Suppl 3):S895–S920Google Scholar
  32. 32.
    Ford ES, Li C, McGuire LC, Mokdad AH, Liu S (2006) Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adults. Obesity 15:1139–1146CrossRefGoogle Scholar
  33. 33.
    He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Horn LV, Jacobs DR, Savage PJ (2006) Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 113:1675–1682PubMedCrossRefGoogle Scholar
  34. 34.
    McKeown NM, Jacques PF, Zhang XL, Sahyoun NR (2008) Dietary magnesium intake is related to metabolic syndrome in older Americans. Eur J Nutr 47:210–216PubMedCrossRefGoogle Scholar
  35. 35.
    Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 294:1–26PubMedCrossRefGoogle Scholar
  36. 36.
    Rodriguez-Moran M, Guerrero-Rometo F (2003) Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 26:1147–1152PubMedCrossRefGoogle Scholar
  37. 37.
    Paolisso G, Sgmbato S, Gambardella A, Pizza G, Tesauro P, Varrichio M, D'Onofrio F (1992) Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 55:1161–1167PubMedGoogle Scholar
  38. 38.
    Song Y, Ridker PM, Manson JE, Cook NR, Buring JE, Liu S (2005) Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care 28:1438–1444PubMedCrossRefGoogle Scholar
  39. 39.
    Mirmiran P, Shab-Bidar S, Hosseini-Esfahani F, Asghari G, Hosseinpour-Niazi S, Azizi F (2012) Magnesium intake and prevalence of metabolic syndrome in adults: Tehran Lipid and Glucose Study. Public Health Nutr 15:693–701PubMedCrossRefGoogle Scholar
  40. 40.
    Madsen E, Gitlin JD (2007) Copper deficiency. Curr Opin Gastroenterol 23:187–192PubMedCrossRefGoogle Scholar
  41. 41.
    Salonen JT, Salonen R, Korpela H, Suntionen S, Tuomilehto J (1991) Serum copper and the risk of acute myocardial infarction: a prospective population study in men in Estern Finland. Am J Epidemiol 134:268–276PubMedGoogle Scholar
  42. 42.
    Saari JT, Dahlen GM (1999) Early and advanced glycation end-products are increased in dietary copper deficiency. J Nutr Biochem 10:210–214PubMedCrossRefGoogle Scholar
  43. 43.
    Sitasawad S, Deshpande M, Katdare M, Tirth S, Parab P (2001) Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM). Diabetes Res Clin Pract 52:77–84PubMedCrossRefGoogle Scholar
  44. 44.
    Galhardi CM, Diniz YS, Rodrigues HG, Faine LA, Burneiko RC, Ribas BO, Novelli EL (2005) Beneficial effects of dietary copper supplementation on serum lipids and antioxidant defenses in rats. Ann Nutr Metab 49:283–288PubMedCrossRefGoogle Scholar
  45. 45.
    Alarcón-Corredor OM, Guerrero Y, Ramírez de Fernández M, D'Jesús I, Burguera M, Burguera JL, Di Bernardo ML, García MY, Alarcón AO (2004) Effect of copper supplementation on lipid profile of Venezuelan hyperlipemic patients. Arch Latinoam Nutr 54:413–418PubMedGoogle Scholar
  46. 46.
    Lefevre M, Keen CL, Lönnerdal B, Hurley LS, Schneeman BO (1986) Copper deficiency-induced hypercholesterolemia: effects on HDLsubfractions and hepatic lipoprotein receptor activity in the rat. J Nutr 116:1735–1746PubMedGoogle Scholar
  47. 47.
    Opsahl W, Zeronian H, Ellison M, Lewis D, Rucker RB, Riggins RS (1982) Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. J Nutr 112:708–716PubMedGoogle Scholar
  48. 48.
    Liu CCF, Medeiros DM (1986) Excess diet copper increases systolic blood pressure in rats. Biol Trace Elem Res 9:15–24CrossRefGoogle Scholar
  49. 49.
    Li Y, Guo H, Wu M, Liu M (2013) Serum and dietary antioxidant status is associated with lower prevalence of the metabolic syndrome in a study in Shanghai, China. Asia Pac J Clin Nutr 22:60–68PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Food ScienceKongju National UniversityYesanSouth Korea
  2. 2.Department of Food and Nutritional SciencesHanbuk UniversityDongducheon-siSouth Korea

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