Copper Supplementation at 8 mg Neither Affects Circulating Lipids nor Liver Function in Apparently Healthy Chilean Men
- 237 Downloads
Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid profile and hepatic function of apparently healthy men. The design was randomized double-blind placebo-controlled clinical trial. Subjects and methods: 60 apparently healthy males aged 18–51 years were randomly assigned to Cu supplementation (n = 30) or placebo (n = 30). There was a nonsignificant reduction of 17 % in total cholesterol in both groups after supplementation. A 23 % nonsignificant reduction was observed in LDL cholesterol levels in the supplemented group. There was a nonsignificant increase of HDL cholesterol of 47 and 66 % in the control and supplemented groups, respectively. Triglyceride levels over 150 mg/dl were found in 17 subjects supplemented and 13 controls at baseline and decreased after supplementation to seven and eight subjects, respectively. There were no effects on serum Cu concentration or ceruloplasmin (protein) and hepatic transaminases. Supplementation of 8 mg Cu for 6 months had no effect on lipid profile of apparently healthy Chilean men with adequate Cu status.
KeywordsCopper Cholesterol LDL Lipid profile Micronutrients
We would like to thank Angélica Letelier for his excellent technical assistance and Sotiris Chaniotakis for his work editing the English of this manuscript. This study was supported by the International Copper Association and FONDECYT no.1070665 and FONDECYT no.1110099.
- 6.Reiser S, Powell A, Yang CY, Canary JJ (1987) Effect of copper intake on blood cholesterol and its lipoprotein distribution in men. Nutr Rep Int 36:641–649Google Scholar
- 17.National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421Google Scholar
- 18.Duh S, Denis J (2005) Laboratory reference ranges values. Pp 98–112. http://www.stedmansonline.com/webFiles/Dict-Stedmans28/APP17.pdf. Accessed 14 May 2013
- 19.Rebolledo A (1998) Encuestas Alimentarias. Rev Chil Nutr 25:28–34Google Scholar
- 20.Gattás V (2008) guía de composición nutricional de alimentos naturales, de la industria y preparaciones chilenas habituales. Universidad de Chile-INTA, SantiagoGoogle Scholar
- 21.Copper (2006) Dietary reference intakes: the essential guide to nutrient requirements. The National Academies, Washington, DCGoogle Scholar