Biological Trace Element Research

, Volume 156, Issue 1–3, pp 1–4 | Cite as

Copper Supplementation at 8 mg Neither Affects Circulating Lipids nor Liver Function in Apparently Healthy Chilean Men

  • Loreto Rojas-Sobarzo
  • Manuel Olivares
  • Alex Brito
  • Miriam Suazo
  • Magdalena Araya
  • Fernando PizarroEmail author


Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid profile and hepatic function of apparently healthy men. The design was randomized double-blind placebo-controlled clinical trial. Subjects and methods: 60 apparently healthy males aged 18–51 years were randomly assigned to Cu supplementation (n = 30) or placebo (n = 30). There was a nonsignificant reduction of 17 % in total cholesterol in both groups after supplementation. A 23 % nonsignificant reduction was observed in LDL cholesterol levels in the supplemented group. There was a nonsignificant increase of HDL cholesterol of 47 and 66 % in the control and supplemented groups, respectively. Triglyceride levels over 150 mg/dl were found in 17 subjects supplemented and 13 controls at baseline and decreased after supplementation to seven and eight subjects, respectively. There were no effects on serum Cu concentration or ceruloplasmin (protein) and hepatic transaminases. Supplementation of 8 mg Cu for 6 months had no effect on lipid profile of apparently healthy Chilean men with adequate Cu status.


Copper Cholesterol LDL Lipid profile Micronutrients 



We would like to thank Angélica Letelier for his excellent technical assistance and Sotiris Chaniotakis for his work editing the English of this manuscript. This study was supported by the International Copper Association and FONDECYT no.1070665 and FONDECYT no.1110099.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Loreto Rojas-Sobarzo
    • 1
  • Manuel Olivares
    • 1
  • Alex Brito
    • 1
    • 2
  • Miriam Suazo
    • 1
  • Magdalena Araya
    • 1
  • Fernando Pizarro
    • 1
    Email author
  1. 1.Institute of Nutrition and Food Technology (INTA)University of ChileMaculChile
  2. 2.United States Department of Agriculture, Western Human Nutrition Research CenterUniversity of California DavisDavisUSA

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