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Biological Trace Element Research

, Volume 154, Issue 1, pp 1–6 | Cite as

Reduced Serum Selenium Concentration in Miscarriage Incidence of Indonesian Subjects

  • Rizky Abdulah
  • Herlambang Noerjasin
  • Leri Septiani
  • Mutakin
  • Irma R. Defi
  • Eka W. Suradji
  • Irma M. Puspitasari
  • Melisa I. Barliana
  • Chiho Yamazaki
  • Minato Nakazawa
  • Hiroshi Koyama
Article

Abstract

Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case–control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. A total of 46 subjects with normal pregnancies and 25 subjects with spontaneous abortion were recruited, and their serum selenium concentrations and serum glutathione peroxidase activities were analyzed. The total serum selenium concentrations in subjects with normal pregnancies were significantly higher than those of subjects with spontaneous abortion; however, the glutathione peroxidase activities were similar in both groups. We further separated the subjects into smoking and nonsmoking groups, and the logistic regression analysis suggested that total serum selenium concentration, but not serum glutathione peroxidase activity or smoking, was significantly correlated with the incidence of miscarriage. The present study thus reaffirms that low serum selenium levels are associated with miscarriage and that selenium plays an important role in pregnancy maintenance.

Keywords

Selenium Glutathione peroxidase Antioxidant Pregnancy Miscarriage 

Notes

Conflict of Interest

None declared

References

  1. 1.
    García-Enguídanos A, Calle ME, Valero J, Luna S, Domínguez-Rojas V (2002) Risk factors in miscarriage: a review. Eur J Obstet Gynecol Reprod Biol 102(2):111–119PubMedCrossRefGoogle Scholar
  2. 2.
    Vural P, Akgül C, Yildirim A, Canbaz M (2000) Antioxidant defence in recurrent abortion. Clin Chim Acta 295(1–2):169–177PubMedCrossRefGoogle Scholar
  3. 3.
    Toy H, Camuzcuoglu H, Camuzcuoglu A, Celik H, Aksoy N (2009) Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss. Gynecol Obstet Invest 69(2):122–127PubMedCrossRefGoogle Scholar
  4. 4.
    Micle O, Muresan M, Antal L, Bodog F, Bodog A (2012) The influence of homocysteine and oxidative stress on pregnancy outcome. J Med Life 5(1):68–73PubMedGoogle Scholar
  5. 5.
    Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179(4073):588–590PubMedCrossRefGoogle Scholar
  6. 6.
    Flohe L, Gunzler WA, Schock HH (1973) Glutathione peroxidase: a selenoenzyme. FEBS Lett 32(1):132–134PubMedCrossRefGoogle Scholar
  7. 7.
    Allen RG, Venkatraj VS (1992) Oxidant and antioxidant in development and differentiation. J Nutr 122(3S):631–635PubMedGoogle Scholar
  8. 8.
    Koyama H, Abdulah R, Ohkubo T, Imai Y, Satoh H, Nagai K (2009) Depressed serum selenoprotein P: possible new predicator of increased risk for cerebrovascular events. Nutr Res 29(2):94–99PubMedCrossRefGoogle Scholar
  9. 9.
    Abdulah R, Kobayashi K, Yamazaki C, Koyama H (2011) Molecular targets of selenium in prostate cancer prevention. Int J Oncol 39(2):301–309PubMedGoogle Scholar
  10. 10.
    Sanmartin C, Plano D, Font M, Palop JA (2011) Selenium and clinical trials: new therapeutic evidence for multiple diseases. Curr Med Chem 18(30):4635–4650PubMedCrossRefGoogle Scholar
  11. 11.
    Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease. Antioxid Redox Signal 14(7):1337–1383PubMedCrossRefGoogle Scholar
  12. 12.
    Mistry HD, Pipkin FB, Redman CW, Poston L (2012) Selenium in reproductive health. Am J Obstet Gynecol 206(1):21–30PubMedCrossRefGoogle Scholar
  13. 13.
    Abdulah R, Miyazaki K, Nakazawa M, Koyama H (2005) Chemical forms of selenium for cancer prevention. J Trace Elem Med Biol 19(2–3):141–150PubMedCrossRefGoogle Scholar
  14. 14.
    Maleki A, Fard MK, Zadeh DH, Mamegani MA, Abasaizadeh S, Mazloomzadeh S (2011) The relationship between plasma level of Se and preeclampsia. Hypertens Pregnancy 30(2):180–187PubMedCrossRefGoogle Scholar
  15. 15.
    Devereux G, McNeill G, Newman G, Turner S, Craig L, Martindale S, Helms P, Seaton A (2007) Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates. Clin Exp Allergy 37(7):1000–1008PubMedCrossRefGoogle Scholar
  16. 16.
    Bedwal RS, Bahuguna A (1994) Zinc, copper and selenium in reproduction. Experientia 50(7):626–640PubMedCrossRefGoogle Scholar
  17. 17.
    Kumar KS, Kumar A, Prakash S, Swamy K, Jagadeesan V, Jyothy A (2002) Role of red cell selenium in recurrent pregnancy loss. J Obstet Gynaecol 22(2):181–183PubMedCrossRefGoogle Scholar
  18. 18.
    Nicoll AE, Norman J, Macpherson A, Acharya U (1999) Association of reduced selenium status in the aetiology of recurrent miscarriage. Br J Obstet Gynaecol 106(11):1188–1191PubMedCrossRefGoogle Scholar
  19. 19.
    Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC (2011) Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr 94(6):1980S–1985SPubMedCrossRefGoogle Scholar
  20. 20.
    Watkinson JH (1966) Fluorometric determination of selenium in biological material with 2,3-diaminonaphthalene. Anal Chem 38(1):92–97PubMedCrossRefGoogle Scholar
  21. 21.
    Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70(1):158–169PubMedGoogle Scholar
  22. 22.
    Development Core Team R (2009) R: a language and environment for statistical computing. R Foundation for Statistical Computing, ViennaGoogle Scholar
  23. 23.
    Jauniaux E, Watson AL, Hempstock J, Bao Y-P, Skepper JN, Burton GJ (2000) Onset of maternal arterial blood flow and placental oxidative stress: a possible factor in human early pregnancy failure. Am J Pathol 157(6):2111–2122PubMedCrossRefGoogle Scholar
  24. 24.
    Burton GJ, Jauniaux E (2004) Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig 11(6):342–352PubMedCrossRefGoogle Scholar
  25. 25.
    Todorova K, Ivanov S, Mazneikova V, Genova M (2005) Glucooxidative stress and spontaneous abortion in pregnant women with diabetes mellitus type 1. Akush Ginekol (Sofiia) 44(4):3–10Google Scholar
  26. 26.
    Simsek M, Naziroglu M, Simsek H, Cay M, Aksakal M, Kumru S (1998) Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion. Cell Biochem Funct 16(4):227–231PubMedCrossRefGoogle Scholar
  27. 27.
    Sane AS, Chokshi SA, Mishra VV, Barad DP, Shah VC, Nagpal S (1991) Serum lipoperoxides in induced and spontaneous abortions. Gynecol Obstet Investig 31(3):172–175CrossRefGoogle Scholar
  28. 28.
    Burton GJ, Hempstock J, Jauniaux E (2003) Oxygen, early embryonic metabolism and free radical-mediated embryopathies. Reprod Biomed Online 6(1):84–96PubMedCrossRefGoogle Scholar
  29. 29.
    Jauniaux E, Hempstock J, Greenwold N, Burton GJ (2003) Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 162(1):115–125PubMedCrossRefGoogle Scholar
  30. 30.
    Lagod L, Paszkowski T, Sikorski R, Rola R (2001) The antioxidant-prooxidant balance in pregnancy complicated by spontaneous abortion. Ginekol Pol 72(12):1073–1078PubMedGoogle Scholar
  31. 31.
    Broughton-Pipkin F (2008) Maternal physiology. In: Edmonds DK (ed) Dewhurst’s textbook of obstetrics & gynaecology, 7th edn. Blackwell, Oxford, pp 10–18Google Scholar
  32. 32.
    King JC (2003) The risk of maternal nutritional depletion and poor outcomes increases in early or closely spaced pregnancies. J Nutr 133(5):1732S–1736SPubMedGoogle Scholar
  33. 33.
    Srivastava S, Mehrotra PK, Srivastava SP, Siddiqui MK (2002) Some essential elements in maternal and cord blood in relation to birth weight and gestational age of the baby. Biol Trace Elem Res 86(2):97–105PubMedCrossRefGoogle Scholar
  34. 34.
    Fall CH, Yajnik CS, Rao S, Davies AA, Brown N, Farrant HJ (2003) Micronutrients and fetal growth. J Nutr 133(5):1747S–1756SPubMedGoogle Scholar
  35. 35.
    Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H (2007) The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab 92(4):1263–1268PubMedCrossRefGoogle Scholar
  36. 36.
    Barrington JW, Lindsay P, James D, Smith S, Roberts A (1996) Selenium deficiency and miscarriage: a possible link? Br J Obstet Gynaecol 103(2):130–132PubMedCrossRefGoogle Scholar
  37. 37.
    Tara F, Rayman MP, Boskabadi H, Ghayour-Mobarhan M, Sahebkar A, Yazarlu O, Ouladan S, Tavallaie S, Azimi-Nezhad M, Shakeri MT, Teymoori MS, Razavi BS, Oladi M, Ferns G (2010) Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial. J Obstet Gynaecol 30(1):30–34PubMedCrossRefGoogle Scholar
  38. 38.
    Rayman MP, Bode P, Redman CW (2003) Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom. Am J Obstet Gynecol 189(5):1343–1349PubMedCrossRefGoogle Scholar
  39. 39.
    Rayman MP (2008) Food-chain selenium and human heath: emphasis on intake. Br J Nutr 100(2):254–268PubMedGoogle Scholar
  40. 40.
    Aursnes I, Smith P, Arnesen H, Akesson B (1988) Correlation between plasma levels of selenium and antithrombin-III. Eur J Haematol 40(1):7–11PubMedCrossRefGoogle Scholar
  41. 41.
    Vunta H, Davis F, Palempalli UD, Bhat D, Arner RJ, Thompson JT, Peterson DG, Reddy CC, Prabhu KS (2007) The anti-inflammatory effects of selenium are mediated through 15-deoxy-Δ12,14-prostaglandin J2 in macrophages. J Biol Chem 282(25):17964–17973PubMedCrossRefGoogle Scholar
  42. 42.
    Moses EK, Johnson MP, Tømmerdal L, Forsmo S, Curran JE, Abraham LJ, Charlesworth JC, Brennecke SP, Blangero J, Austgulen R (2008) Genetic association of preeclampsia to the inflammatory response gene SEPS1. Am J Obstet Gynecol 198(3):336.e1–5CrossRefGoogle Scholar
  43. 43.
    Wang Y, Walsh SW (1996) Antioxidant activities and mRNA expression of superoxide dismutase, catalase, and glutathione peroxidase in normal and preeclamptic placentas. J Soc Gynecol Investig 3(4):179–184PubMedCrossRefGoogle Scholar
  44. 44.
    Vanderlelie J, Venardos K, Clifton VL, Gude NM, Clarke FM, Perkins AV (2005) Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae. Placenta 26(1):53–58PubMedCrossRefGoogle Scholar
  45. 45.
    Mistry HD, Kurlak LO, Williams PJ, Ramsay MM, Symonds ME, Broughton-Pipkin F (2010) Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta 31(5):401–408PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rizky Abdulah
    • 1
    • 2
  • Herlambang Noerjasin
    • 3
  • Leri Septiani
    • 4
  • Mutakin
    • 2
    • 5
  • Irma R. Defi
    • 2
  • Eka W. Suradji
    • 2
  • Irma M. Puspitasari
    • 1
    • 2
  • Melisa I. Barliana
    • 1
  • Chiho Yamazaki
    • 2
  • Minato Nakazawa
    • 2
  • Hiroshi Koyama
    • 2
  1. 1.Department of Pharmacology and Clinical Pharmacy, Faculty of PharmacyUniversitas PadjadjaranJatinangorIndonesia
  2. 2.Department of Public HealthGunma University Graduate School of MedicineMaebashiJapan
  3. 3.Department of Obstetrics and Gynecology, Faculty of Medicine and Health SciencesUniversitas JambiJambiIndonesia
  4. 4.Department of Obstetrics and Gynecology, Faculty of MedicineUniversitas Padjadjaran - Hasan Sadikin HospitalBandungIndonesia
  5. 5.Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of PharmacyUniversitas PadjadjaranBandungIndonesia

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