Biological Trace Element Research

, Volume 152, Issue 3, pp 327–332 | Cite as

Serum Trace Elements Levels in Preeclampsia and Eclampsia: Correlation with the Pregnancy Disorder

  • Touhida Ahsan
  • Salina Banu
  • Quamrun Nahar
  • Monira Ahsan
  • Md. Nazrul Islam Khan
  • Sheikh Nazrul Islam


Preeclampsia and eclampsia are fatal medical complications of pregnancy accounting for 20–80 % of increased maternal death in developing countries. Their aetiologies are still under investigation. Serum trace elements have been suggested to be involved in the pathogenesis of preeclampsia. Aim of this study was to address the correlation of serum trace elements with preeclampsia and eclampsia. It was a comparative cross-sectional study conducted on conveniently recruited 44 preeclampsia, 33 eclampsia and 27 normotensive pregnant patients. Atomic absorption spectrometry was employed to analyse serum concentrations of Ca, Mg, Cu, Zn and Fe. Data were analysed by Student's t test, one-way analysis of variance and multinomial logistic and binary regression analyses. p < 0.05 was considered as a level of significance. In preeclampsia, the serum Ca and Mg were significantly lower than those in eclampsia, while Cu and Zn values were higher. Significant changes of Ca, Mg and Cu were noted among preeclampsia, eclampsia and pregnant control. Serum Ca and Mg indicated a positive association, and Cu gave a negative association in preeclampsia. Cu/Fe ratio was high in eclampsia. Significant correlations of Mg with Zn in eclampsia and Mg with Fe in preeclampsia and eclampsia were predicted. Significant changes in serum trace element levels were present in preeclampsia and eclampsia that may have a link with the pathogenesis of pregnancy disorder.


Trace elements Correlation Association Preeclampsia Eclampsia 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Touhida Ahsan
    • 1
  • Salina Banu
    • 2
  • Quamrun Nahar
    • 3
  • Monira Ahsan
    • 4
  • Md. Nazrul Islam Khan
    • 2
  • Sheikh Nazrul Islam
    • 2
  1. 1.Department of Gynaecology and ObstetricsIbn Sina Medical CollegeDhakaBangladesh
  2. 2.Institute of Nutrition and Food ScienceUniversity of DhakaDhakaBangladesh
  3. 3.Department of Biochemistry and Cell Biology, Biomedical Research Group, BIRDEMDhakaBangladesh
  4. 4.Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of DhakaDhakaBangladesh

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