Evaluating the Suitability of Postnuclear Supernatants as In Vitro Models for Assessing Cadmium- and Other Xenobiotic-Induced Neurotoxicity on Crucial Enzymatic Parameters
Govil et al.  have recently provided an interesting report on the use of murine brain-derived postnuclear supernatants as an in vitro model for the assessment of neurotoxic effects of cadmium (Cd). The authors focus on an important topic within the neurotoxicity arena and describe an extensive neurochemical screening via the study of the in vitro effects of different Cd-chloride (CdCl2) concentrations (1, 5, and 10 mM) on the following crucial enzymatic and nonenzymatic parameters: catalase activity, superoxide dismutase activity, glutathione-S-transferase activity, acetylcholinesterase (AChE) activity, sodium–potassium adenosinetriphosphatase (Na+, K+-ATPase) activity, reduced glutathione content, and thiol(s) content analysis . It is our opinion that the methodology used by the authors for the neurochemical analysis is appropriate and so is the studied biomarker selection. However, there are certain important issues addressed within this report , on which we would like to...
KeywordsCdCl2 Adenosinetriphosphatase CdSO4 Concentration Window Toxic Encephalopathy
Conflict of interest
All authors (AZ, RTC, ST, and GSB) declare that there are no conflicts of interest.
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