Biological Trace Element Research

, Volume 151, Issue 1, pp 85–91 | Cite as

Ferulic Acid Modulates Fluoride-Induced Oxidative Hepatotoxicity in Male Wistar Rats

  • Lakshmikanthan Panneerselvam
  • Kavitha Subbiah
  • Angelin Arumugam
  • J. Giftson Senapathy


The present study is aimed to evaluate the protective effect of ferulic acid (FA) on fluoride-induced oxidative hepatotoxicity in male Wistar rats. Fluoride (25 mg/L) was given orally to induce hepatotoxicity for 12 weeks. Hepatic damage were assessed using status of pathophysiological markers like serum marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, gamma glutamyl transferase, lactate dehydrogenase, bilirubin, lipid profile, total protein content levels, and histopathological studies. Treatment with FA significantly reduced the degree of histological abberations and rescued lipid peroxidation, as observed from reduced levels of lipid hydroperoxides, nitric oxide, restored levels of enzymic and non-enzymic antioxidants, and total protein content, with a concomitant decline in the levels of marker enzymes and lipid profile in fluoride-induced rats. These results suggest that ferulic acid has the ability to protect fluoride-induced hepatic damage.


Fluoride Ferulic acid Oxidative stress Hepatotoxicity 



Ferulic acid


Reactive oxygen species


Superoxide dismutase




Reduced glutathione


Gultathione peroxidase


Thiobarbituric acid reactive substances


Lipid hydroperoxides

Vitamin C

Ascorbic acid


Nitric oxide


Aspartate transaminase


Alanine transaminase


Lactate dehydrogenase


Gamma glutamyl transferase


Alkaline phosphatase


Acid phosphatase




Low-density lipoprotein


High-density lipoprotein


Very low-density lipoprotein


Ducan’s multiple range test



The authors thank the management of Karunya University for providing Karunya Research Grant to carry out this work successfully and thank Dr. Pauline Das, English Department, for language proof reading and Mr. Prakash for his assistance in histological and biochemical works of this study.

Conflicts of Interest

The authors have declared no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Lakshmikanthan Panneerselvam
    • 1
  • Kavitha Subbiah
    • 1
  • Angelin Arumugam
    • 1
  • J. Giftson Senapathy
    • 1
  1. 1.Department of Biotechnology, School of Biotechnology and Health SciencesKarunya UniversityCoimbatoreIndia

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