Biological Trace Element Research

, Volume 149, Issue 1, pp 117–122 | Cite as

Toxic Metals in Breast Milk Samples from Ankara, Turkey: Assessment of Lead, Cadmium, Nickel, and Arsenic Levels

  • Aylin Gürbay
  • Mohammad Charehsaz
  • Ayşe Eken
  • Ahmet Sayal
  • Gözde Girgin
  • Murat Yurdakök
  • Şule Yiğit
  • Dilek Demir Erol
  • Gönül Şahin
  • Ahmet Aydın
Article

Abstract

Toxic metals are one of the significant groups of chemical contaminants that humans are exposed to by oral, inhalation, and dermal routes. Exposure to these chemicals begins with intrauterine life and continues during lactation period at the first years of life. Breastfeeding has a much more special place than other nutrition options for infants. However, when possibility of contaminant transfer by breast milk is considered, its safety and quality is essential. Regarding infant and mother health and limited number of information on this field in Turkey, measuring contamination levels in breast milk is important. Therefore, in the present study, lead (Pb), cadmium (Cd), nickel (Ni), and arsenic (As) levels were measured by atomic absorption spectrometry in 64 breast milk samples obtained from mothers from Ankara, Turkey. Pb and Ni levels in breast milk samples were found to be 391.45 ± 269.01 μg/l and 43.94 ± 33.82 μg/l (mean ± SD), respectively. Cd was found only in one of 64 samples, and the level was 4.62 μg/l. As level was below the limit of quantification (LOQ, 7.6 μg/l) in all samples. These findings will accurately direct strategies and solutions of protection against contaminants in order to reduce their levels in biological fluids.

Keywords

Breast milk Lead Cadmium Nickel Arsenic Atomic absorption spectrometry 

References

  1. 1.
    Le Huerou-Luron I, Blat S, Boudry G (2010) Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects. Nutr Res Rev 23(1):23–36PubMedCrossRefGoogle Scholar
  2. 2.
    Ursinyova M, Masanova V (2005) Cadmium, lead and mercury in human milk from Slovakia. Food Addit Contam 22(6):579–589PubMedCrossRefGoogle Scholar
  3. 3.
    Dorea JG (2004) Mercury and lead during breast-feeding. Br J Nutr 92(1):21–40PubMedCrossRefGoogle Scholar
  4. 4.
    EFSA (2009) Cadmium in food. EFSA J 980:1–139Google Scholar
  5. 5.
    EFSA (2010) Scientific opinion on lead in food. EFSA J 8:1–147Google Scholar
  6. 6.
    Das KK, Das SN, Dhundasi SA (2008) Nickel, its adverse health effects & oxidative stress. Indian J Med Res 128(4):412–425PubMedGoogle Scholar
  7. 7.
    Vahter M (2009) Effects of arsenic on maternal and fetal health. Annu Rev Nutr 29:381–399PubMedCrossRefGoogle Scholar
  8. 8.
    IARC (International Agency for Research on Cancer) (2012) Classified by the IARC Monographs, Volumes 1–102Google Scholar
  9. 9.
    Golding J (1997) Unnatural constituents of breast milk—medication, lifestyle, pollutants, viruses. Early Hum Dev 49(Suppl):S29–S43PubMedCrossRefGoogle Scholar
  10. 10.
    Cerna M, Spevackova V, Batariova A, Smid J, Cejchanova M, Ocadlikova D, Bavorova H, Benes B, Kubinova R (2007) Human biomonitoring system in the Czech Republic. Int J Hyg Environ Health 210(3–4):495–499PubMedCrossRefGoogle Scholar
  11. 11.
    Needham LL, Wang RY (2002) Analytic considerations for measuring environmental chemicals in breast milk. Environ Health Perspect 110(6):A317–A324PubMedCrossRefGoogle Scholar
  12. 12.
    Solomon GM, Weiss PM (2002) Chemical contaminants in breast milk: time trends and regional variability. Environ Health Perspect 110(6):A339–A347PubMedCrossRefGoogle Scholar
  13. 13.
    Massart F, Gherarducci G, Marchi B, Saggese G (2008) Chemical biomarkers of human breast milk pollution. Biomark Insights 3:159–169PubMedGoogle Scholar
  14. 14.
    Turan S, Saygi S, Kilic Z, Acar O (2001) Determination of heavy metal contents in human colostrum samples by electrothermal atomic absorption spectrophotometry. J Trop Pediatr 47(2):81–85PubMedCrossRefGoogle Scholar
  15. 15.
    Kirel B, Aksit MA, Bulut H (2005) Blood lead levels of maternal-cord pairs, children and adults who live in a central urban area in Turkey. Turk J Pediatr 47(2):125–131PubMedGoogle Scholar
  16. 16.
    Orun E, Yalcin SS, Aykut O, Orhan G, Morgil GK, Yurdakok K, Uzun R (2011) Breast milk lead and cadmium levels from suburban areas of Ankara. Sci Total Environ 409(13):2467–2472PubMedCrossRefGoogle Scholar
  17. 17.
    Minor and trace elements in human milk (1989) World Health Organisation. http://whqlibdoc.who.int/publications/1989/9241561211.pdf. Accessed 12.03.2012
  18. 18.
    Choi J, Tanaka T, Koren G, Ito S (2008) Lead exposure during breastfeeding. Can Fam Physician 54(4):515–516PubMedGoogle Scholar
  19. 19.
    Iarushkin V (1992) Heavy metals in the mother-newborn infant biological system in the technology-related biogeochemical environment. Gig Sanit 5–6:13–15PubMedGoogle Scholar
  20. 20.
    Guidi B, Ronchi S, Ori E, Varni PF, Cassinadri T, Tripodi A, Borghi A, Mattei F, Demaria F, Galavotti E et al (1992) Lead concentrations in breast milk of women living in urban areas compared with women living in rural areas. Pediatr Med Chir 14(6):611–616PubMedGoogle Scholar
  21. 21.
    Rodriguez Rodriguez EM, Delgado Uretra E, Diaz Romero RC (1999) Concentrations of cadmium and lead in different types of milk. Z Lebensm Unters Forsch 208(3):162–168CrossRefGoogle Scholar
  22. 22.
    Namihira D, Saldivar L, Pustilnik N, Carreon GJ, Salinas ME (1993) Lead in human blood and milk from nursing women living near a smelter in Mexico City. J Toxicol Environ Health 38(3):225–232PubMedCrossRefGoogle Scholar
  23. 23.
    Fong K-Y LF-H, Zheng Y-Q, Bai W-H (1988) The effect on fetus due to lead exposure of women. Chin J Ind Hyg Occup Dis 6:265–268Google Scholar
  24. 24.
    Toth E, Benkone VZ, Oroszlan G, Ulveczky E (1989) Prenatal lead blood levels in a city heavily exposed to lead. Orv Hetil 130(50):2679–2681PubMedGoogle Scholar
  25. 25.
    Saleh MA, Ragab AA, Kamel A, Jones J, el-Sebae AK (1996) Regional distribution of lead in human milk from Egypt. Chemosphere 32(9):1859–1867PubMedCrossRefGoogle Scholar
  26. 26.
    Gulson BL, Jameson CW, Mahaffey KR, Mizon KJ, Patison N, Law AJ, Korsch MJ, Salter MA (1998) Relationships of lead in breast milk to lead in blood, urine, and diet of the infant and mother. Environ Health Perspect 106(10):667–674PubMedCrossRefGoogle Scholar
  27. 27.
    Koyashiki GA, Paoliello MM, Matsuo T, de Oliveira MM, Mezzaroba L, Carvalho Mde F, Sakuma AM, Turini C, Vannuchi MT, Barbosa CS (2010) Lead levels in milk and blood from donors to the Breast Milk Bank in Southern Brazil. Environ Res 110(3):265–271PubMedCrossRefGoogle Scholar
  28. 28.
    Lead, cadmium and mercury. Trace elements in human nutrition and health (1996) World Health Organization. http://whqlibdoc.who.int/publications/1996/9241561734_eng.pdf. Accessed 12.03.2012
  29. 29.
    Vracko P, Tuomisto J, Grad J, Kunseler E (2009) Exposure of children to chemical hazards in food. http://www.euro.who.int/__data/assets/pdf_file/0004/97042/4.4.-Exposure-of-children-to-chemical-hazards-in-food-EDITED_layouted.pdf. Accessed 12.03.2012 2012
  30. 30.
    Sikorski R, Paszkowski T, Radomanski T Jr, Szkoda J (1989) Cadmium contamination of early human milk. Gynecol Obstet Invest 27(2):91–93PubMedCrossRefGoogle Scholar
  31. 31.
    Hallen IP, Jorhem L, Lagerkvist BJ, Oskarsson A (1995) Lead and cadmium levels in human milk and blood. Sci Total Environ 166:149–155PubMedCrossRefGoogle Scholar
  32. 32.
    Dabeka RW, Karpinski KF, McKenzie AD, Bajdik CD (1986) Survey of lead, cadmium and fluoride in human milk and correlation of levels with environmental and food factors. Food Chem Toxicol 24(9):913–921PubMedCrossRefGoogle Scholar
  33. 33.
    Vuori E, Vetter M, Kuitunen P, Salmela S (1983) Cadmium in Finnish breast milk, a longitudinal study. Arch Toxicol 53(3):207–211PubMedCrossRefGoogle Scholar
  34. 34.
    Stawarz R, Formicki G, Massanyi P (2007) Daily fluctuations and distribution of xenobiotics, nutritional and biogenic elements in human milk in Southern Poland. J Environ Sci Health, Part A: Tox Hazard Subst Environ Eng 42(8):1169–1175CrossRefGoogle Scholar
  35. 35.
    Oskarsson A, Palminger Hallen I, Sundberg J, Petersson Grawe K (1998) Risk assessment in relation to neonatal metal exposure. Analyst 123(1):19–23PubMedCrossRefGoogle Scholar
  36. 36.
    Casey CE (1977) The content of some trace elements in infant milk foods and supplements available in New Zealand. N Z Med J 85(585):275–278PubMedGoogle Scholar
  37. 37.
    Feeley RM, Eitenmiller RR, Jones JB, Barnhart H (1983) Manganese, cobalt, nickel, silicon and aluminum in human milk during early lactation. Fed Proc 42(4):921(abstr)Google Scholar
  38. 38.
    Casey CE, Neville MC (1987) Studies in human lactation 3: molybdenum and nickel in human milk during the first month of lactation. Am J Clin Nutr 45(5):921–926PubMedGoogle Scholar
  39. 39.
    Krachler M, Prohaska T, Koellensperger G, Rossipal E, Stingeder G (2000) Concentrations of selected trace elements in human milk and in infant formulas determined by magnetic sector field inductively coupled plasma-mass spectrometry. Biol Trace Elem Res 76(2):97–112PubMedCrossRefGoogle Scholar
  40. 40.
    Rica CC, Kirkbright GF (1982) Determination of trace concentrations of lead and nickel in human milk by electrothermal atomisation atomic absorption spectrophotometry and inductively-coupled plasma emission spectroscopy. Sci Total Environ 22(3):193–201PubMedCrossRefGoogle Scholar
  41. 41.
    Turkmen A, Turkmen M, Tepe Y, Cekic M (2010) Metals in tissues of fish from Yelkoma Lagoon, northeastern Mediterranean. Environ Monit Assess 168(1–4):223–230PubMedCrossRefGoogle Scholar
  42. 42.
    Cameron KS, Buchner V, Tchounwou PB (2011) Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review. Rev Environ Heal 26(2):81–92CrossRefGoogle Scholar
  43. 43.
    Tolerable upper intake levels for vitamins and minerals (2006) EFSA, Scientific Committee on Food, Scientific Panel on Dietetic Products, Nutrition and Allergies 2011:347–362Google Scholar
  44. 44.
    Samanta G, Das D, Mandal BK, Chowdhury TR, Chakraborti D, Pal A, Ahamed S (2007) Arsenic in the breast milk of lactating women in arsenic-affected areas of West Bengal, India and its effect on infants. J Environ Sci Health, Part A: Tox Hazard Subst Environ Eng 42(12):1815–1825CrossRefGoogle Scholar
  45. 45.
    Concha G, Vogler G, Lezcano D, Nermell B, Vahter M (1998) Exposure to inorganic arsenic metabolites during early human development. Toxicol Sci 44(2):185–190PubMedCrossRefGoogle Scholar
  46. 46.
    Sternowsky HJ, Moser B, Szadkowsky D (2002) Arsenic in breast milk during the first 3 months of lactation. Int J Hyg Environ Health 205(5):405–409PubMedCrossRefGoogle Scholar
  47. 47.
    Parr RM, DeMaeyer EM, Iyengar VG, Byrne AR, Kirkbright GF, Schoch G, Niinisto L, Pineda O, Vis HL, Hofvander Y et al (1991) Minor and trace elements in human milk from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Zaire. Results from a WHO/IAEA joint project. Biol Trace Elem Res 29(1):51–75PubMedCrossRefGoogle Scholar
  48. 48.
    Watanabe C, Inaoka T, Matsui T, Ishigaki K, Murayama N, Ohtsuka R (2003) Effects of arsenic on younger generations. J Environ Sci Health, Part A: Tox Hazard Subst Environ Eng 38(1):129–139CrossRefGoogle Scholar
  49. 49.
    Fangstrom B, Moore S, Nermell B, Kuenstl L, Goessler W, Grander M, Kabir I, Palm B, Arifeen SE, Vahter M (2008) Breast-feeding protects against arsenic exposure in Bangladeshi infants. Environ Health Perspect 116(7):963–969PubMedCrossRefGoogle Scholar
  50. 50.
    Tillett T (2008) Is arsenic “lactation intolerant”? Study indicates low excretion in breast milk. Environ Health Perspect 116(7):A306PubMedCrossRefGoogle Scholar
  51. 51.
    Sguassero Y Optimal duration of exclusive breastfeeding: RHL commentary. World Health Organization. http://apps.who.int/rhl/pregnancy_childbirth/care_after_childbirth/yscom/en/index.html. Accessed 12.03.2012
  52. 52.
    UNICEF (1999) Breastfeeding: foundation for a healthy future. http://www.unicef.org/publications/files/pub_brochure_en.pdf. Accessed 12.03.2012
  53. 53.
    Nakamori M, Ninh NX, Isomura H, Yoshiike N, Hien VT, Nhug BT, Nhien NV, Nakano T, Khan NC, Yamamoto S (2009) Nutritional status of lactating mothers and their breast milk concentration of iron, zinc and copper in rural Vietnam. J Nutr Sci Vitaminol 55(4):338–345PubMedCrossRefGoogle Scholar
  54. 54.
    Samur G (2008) Anne Sütü. Republic of Turkey Ministry of Health. http://www.beslenme.saglik.gov.tr/content/files/yayinlar/kitaplar/beslenme_bilgi_serisi_1/a7.pdf. Accessed 12.03.2012

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Aylin Gürbay
    • 1
  • Mohammad Charehsaz
    • 2
  • Ayşe Eken
    • 3
    • 4
  • Ahmet Sayal
    • 3
  • Gözde Girgin
    • 1
  • Murat Yurdakök
    • 5
  • Şule Yiğit
    • 5
  • Dilek Demir Erol
    • 2
  • Gönül Şahin
    • 1
    • 6
  • Ahmet Aydın
    • 2
  1. 1.Faculty of Pharmacy, Department of Pharmaceutical ToxicologyHacettepe UniversityAnkaraTurkey
  2. 2.Faculty of Pharmacy, Department of Pharmaceutical ToxicologyYeditepe UniversityİstanbulTurkey
  3. 3.Department of ToxicologyGülhane Military Medical AcademyAnkaraTurkey
  4. 4.Faculty of Pharmacy, Department of ToxicologyErciyes UniversityKayseriTurkey
  5. 5.Faculty of Medicine, Department of Pediatrics, Section of NeonatologyHacettepe UniversityAnkaraTurkey
  6. 6.Faculty of Pharmacy, Department of ToxicologyEast Mediterranean UniversityFamagustaTurkey

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