Biological Trace Element Research

, Volume 147, Issue 1–3, pp 285–291 | Cite as

Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats

  • Yingjie Li
  • Yuanyuan Zheng
  • Jianxin Qian
  • Xinmin Chen
  • Zhilei Shen
  • Liping Tao
  • Hongxia Li
  • Haihong Qin
  • Min LiEmail author
  • Hui ShenEmail author


Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.


Psychological stress Zinc Iron Oxidative stress Erythropoiesis 



This work was supported in part by the grants from National Natural Science Foundation of China (no. 30872120, 81001243), Natural Science Foundation of Shanghai (no.10ZR1437400) and Shanghai Health Bureau (nos. 08GWD23, 08GWQ012).


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yingjie Li
    • 1
  • Yuanyuan Zheng
    • 2
  • Jianxin Qian
    • 3
  • Xinmin Chen
    • 1
  • Zhilei Shen
    • 1
  • Liping Tao
    • 1
  • Hongxia Li
    • 1
  • Haihong Qin
    • 1
  • Min Li
    • 1
    Email author
  • Hui Shen
    • 1
    Email author
  1. 1.Department of Military HygieneSecond Military Medical UniversityShanghaiChina
  2. 2.Department of ImmunologySecond Military Medical UniversityShanghaiChina
  3. 3.Department of Medical OncologyChangzheng HospitalShanghaiChina

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