Biological Trace Element Research

, Volume 145, Issue 3, pp 361–368 | Cite as

Organ Histopathological Changes and its Function Damage in Mice Following Long-term Exposure to Lanthanides Chloride

  • Jie Cheng
  • Na Li
  • Jingwei Cai
  • Zhe Cheng
  • Renping Hu
  • Qian Zhang
  • Fangfang Wan
  • Qingqing Sun
  • Suxing Gui
  • Xuezi Sang
  • Ling Wang
  • Fashui HongEmail author


Due to increasing applications of lanthanides (Ln) in industry and daily life, numerous studies confirmed that Ln exposure may result in organ damages in mice and rats, while very few studies focused on several organs damages simultaneously. In order to compare the toxicity of Ln on organs, mice were exposed to LaCl3, CeCl3, and NdCl3 of a dose of 20 mg/kg body weight for consecutive 60 days, respectively, then histopathological changes of liver, kidney, and heart, and their function were investigated. The results showed that long-term exposure to Ln caused cell necrosis and basophilia of liver, ambiguity of renal tubule architecture, congestion of blood vessel and capillary of kidney, and heart hemorrhage. The histopathological changes of liver, kidney, and heart in mice caused by Ce3+ was most severe; the effect by Nd3+ was slighter than Ce3+ but more severe than La3+. The assay of serum biochemical parameters suggested that Ln exposure severely impaired the functions of liver, kidney, and myocardium in mice. These findings suggested that long-term exposure to Ln resulted in histopathological changes of liver, kidney, and heart, and their function damages. Therefore, we thought that long-term application of the products containing Ln on human should be cautious.


Lanthanides Long-term exposure Mice Histopathological changes Biochemical function 



This work was supported by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Natural Science Foundation of China (grant no. 30901218), the “Chun-Tsung scholar” Foundation of Soochow University, and the New Ideas Foundation of Student of Soochow University (grant no. 57315927).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jie Cheng
    • 1
  • Na Li
    • 1
    • 2
  • Jingwei Cai
    • 1
  • Zhe Cheng
    • 1
  • Renping Hu
    • 1
  • Qian Zhang
    • 1
  • Fangfang Wan
    • 1
  • Qingqing Sun
    • 1
  • Suxing Gui
    • 1
  • Xuezi Sang
    • 1
  • Ling Wang
    • 1
  • Fashui Hong
    • 1
    Email author
  1. 1.Medical CollegeSoochow UniversitySuzhouPeople’s Republic of China
  2. 2.General Hospital of Jincheng Anthracite Mining Group Co. Ltd.JinchengPeople’s Republic of China

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