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Biological Trace Element Research

, Volume 144, Issue 1–3, pp 396–406 | Cite as

The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

  • Sangun Lee
  • Ippei Takahashi
  • Masashi Matsuzaka
  • Kiyonori Yamai
  • Kazuma Danjo
  • Takako Kumagai
  • Takashi Umeda
  • Kazuyoshi Itai
  • Shigeyuki Nakaji
Article

Abstract

We evaluated the relationships between neutrophil-related functions and serum selenium (Se) concentration in the general population. We examined 800 subjects who had participated in the Iwaki Health Promotion Project in 2005 to determine the relationships between serum Se concentration and neutrophil-related functions such as the production capability of reactive oxygen species (ROS), phagocytic activity, and serum opsonic activity (SOA). In nonstimulated neutrophils, i.e., in neutrophils at their baseline condition before the application of the phagocytic stimulus, the serum Se concentration tends to be high and the ROS production tends to be low. With regard to SOA, there was a significant negative correlation between lucigenin-dependent chemiluminescence and serum Se concentration in both men and women. Moreover, in women, a significant negative correlation was observed between luminol-dependent chemiluminescence and serum Se concentration. These results suggest that subjects with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil ROS production. In addition, the findings of our study suggest that women rather than men benefit more from Se against oxidative stress.

Keywords

Selenium Oxidative burst activity Phagocytic activity Serum opsonic activity Neutrophil 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sangun Lee
    • 1
    • 2
  • Ippei Takahashi
    • 1
  • Masashi Matsuzaka
    • 1
  • Kiyonori Yamai
    • 1
  • Kazuma Danjo
    • 1
  • Takako Kumagai
    • 1
  • Takashi Umeda
    • 1
  • Kazuyoshi Itai
    • 3
  • Shigeyuki Nakaji
    • 1
  1. 1.Department of Social MedicineHirosaki University Graduate School of MedicineHirosakiJapan
  2. 2.Department of Physical TherapyAomori University of Health and WelfareAomoriJapan
  3. 3.Department of Hygiene and preventive MedicineIwate Medical UniversityMoriokaJapan

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