Biological Trace Element Research

, Volume 144, Issue 1–3, pp 992–1002 | Cite as

Magnesium Supplementation through Seaweed Calcium Extract Rather than Synthetic Magnesium Oxide Improves Femur Bone Mineral Density and Strength in Ovariectomized Rats

  • Yun Jung Bae
  • So Young Bu
  • Jae Young Kim
  • Jee-Young Yeon
  • Eun-Wha Sohn
  • Ki-Hyo Jang
  • Jae-Cheol Lee
  • Mi-Hyun Kim


Commercially available seaweed calcium extract can supply high amounts of calcium as well as significant amounts of magnesium and other microminerals. The purpose of this study was to investigate the degree to which the high levels of magnesium in seaweed calcium extract affects the calcium balance and the bone status in ovariectomized rats in comparison to rats supplemented with calcium carbonate and magnesium oxide. A total of 40 Sprague–Dawley female rats (7 weeks) were divided into four groups and bred for 12 weeks: sham-operated group (Sham), ovariectomized group (OVX), ovariectomized with inorganic calcium and magnesium supplementation group (OVX-Mg), and ovariectomized with seaweed calcium and magnesium supplementation group (OVX-SCa). All experimental diets contained 0.5% calcium. The magnesium content in the experimental diet was 0.05% of the diet in the Sham and OVX groups and 0.1% of the diet in the OVX-Mg and OVX-SCa groups. In the calcium balance study, the OVX-Mg and OVX-SCa groups were not significantly different in calcium absorption compared to the OVX group. However, the femoral bone mineral density and strength of the OVX-SCa group were higher than those of the OVX-Mg and OVX groups. Seaweed calcium with magnesium supplementation or magnesium supplementation alone did not affect the serum ALP and CTx levels in ovariectomized rats. In summary, consumption of seaweed calcium extract or inorganic calcium carbonate with magnesium oxide demonstrated the same degree of intestinal calcium absorption, but only the consumption of seaweed calcium extract resulted in increased femoral bone mineral density and strength in ovariectomized rats. Our results suggest that seaweed calcium extract is an effective calcium and magnesium source for improving bone health compared to synthetic calcium and magnesium supplementation.


Seaweed calcium Magnesium Bone status Calcium balance Ovariectomy 



This work was supported by grant No. RT105-01-02 from the Regional Technology Innovation Program of the Ministry of Commerce, Industry and Energy (MOCIE). We would like express our appreciation to Lavon Smith for assistance in manuscript preparation.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yun Jung Bae
    • 1
  • So Young Bu
    • 2
  • Jae Young Kim
    • 3
  • Jee-Young Yeon
    • 4
  • Eun-Wha Sohn
    • 5
  • Ki-Hyo Jang
    • 6
  • Jae-Cheol Lee
    • 6
  • Mi-Hyun Kim
    • 6
  1. 1.Department of Food and Nutritional SciencesHanbuk UniversityDongducheonSouth Korea
  2. 2.Division of Food ScienceKyungil UniversityGyeongsanSouth Korea
  3. 3.Research Center for Biophamaceutical Lead MoleculeBucheonSouth Korea
  4. 4.Department of Food and NutritionSookmyung Women’s UniversitySeoulSouth Korea
  5. 5.Department of Herbal Medicine ResourceKangwon National UniversitySamcheokSouth Korea
  6. 6.Department of Food and NutritionKangwon National UniversitySamcheokSouth Korea

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