Continuous Positive Airway Pressure Therapy Reduces Oxidative Stress Markers and Blood Pressure in Sleep Apnea–Hypopnea Syndrome Patients
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Sleep apnea–hypopnea syndrome (SAHS) is characterized by recurrent episodes of hypoxia/reoxygenation, which seems to promote oxidative stress. SAHS patients experience increases in hypertension, obesity and insulin resistance (IR). The purpose was to evaluate in SAHS patients the effects of 1 month of treatment with continuous positive airway pressure (CPAP) on oxidative stress and the association between oxidative stress and insulin resistance and blood pressure (BP). Twenty-six SAHS patients requiring CPAP were enrolled. Measurements were recorded before and 1 month after treatment. Cellular oxidative stress parameters were notably decreased after CPAP. Intracellular glutathione and mitochondrial membrane potential increased significantly. Also, total antioxidant capacity and most of the plasma antioxidant activities increased significantly. Significant decreases were seen in BP. Negative correlations were observed between SAHS severity and markers of protection against oxidative stress. BP correlated with oxidative stress markers. In conclusion, we observed an obvious improvement in oxidative stress and found that it was accompanied by an evident decrease in BP with no modification in IR. Consequently, we believe that the decrease in oxidative stress after 1 month of CPAP treatment in these patients is not contributing much to IR genesis, though it could be related to the hypertension etiology.
KeywordsContinuous positive airway pressure Hypertension Insulin resistance Oxidative stress Sleep apnea–hypopnea syndrome
The authors thank Juan Alcaide (technician) for his technical support in developing our laboratory techniques. This work was supported in part by grants from the Andalusian Health Service (SAS PI-0326/2007) and the Spanish Ministry of Education and Science (SAF2006-12984). Murri is a recipient of a predoctoral Investigator Personal Formation grant (BES-2007-16594) from the Spanish Ministry of Education and Science, and Cardona is a recipient of CP07/0095 grant. The authors thank the Pneumology and Hematology service and the pneumology nursing staff of the Virgen de la Victoria Hospital, Málaga.
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