Biological Trace Element Research

, Volume 143, Issue 2, pp 695–701

Chronic Fluoride Exposure Has a Role in Etiology of Coronary Artery Ectasia: Sialic Acid/Glycosaminoglycan Ratio

  • Ozkan Dede
  • Ercan Varol
  • Ahmet Altinbas
  • Simge Varol
Article

DOI: 10.1007/s12011-010-8913-9

Cite this article as:
Dede, O., Varol, E., Altinbas, A. et al. Biol Trace Elem Res (2011) 143: 695. doi:10.1007/s12011-010-8913-9

Abstract

The sialic acid/glycosaminoglycan ratio was determined in 35 coronary artery ectasia patients and 35 control subjects to determine the possible role of fluoride in the etiology of the disease. The coronary artery ectasia patients and controls were selected from subjects who underwent coronary angiography. The mean serum sialic acid level was significantly lower in patients with coronary artery ectasia (CAE) than in controls (340.3 ± 28.6 vs. 427.0 ± 15.9 μg/mL, respectively; p < 0.001). The mean serum glycosaminoglycan level was significantly higher in patients with CAE than in controls (5,013.1 ± 158.6 vs. 3,833.6 ± 237.1 μg/mL, respectively; p < 0.001). The sialic acid/glycosaminoglycan ratio in patients with coronary artery ectasia was significantly lower than in controls (0.068 ± 0.007 vs. 0.111 ± 0.005; p < 0.001). There was more than 38.7% reduction in this ratio in patients with CAE when compared with controls. We demonstrated that chronic fluoride exposure has an important role in pathogenesis of coronary artery ectasia.

Keywords

Endemic fluorosis Coronary artery ectasia Sialic acid Glycosaminoglycan 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ozkan Dede
    • 1
  • Ercan Varol
    • 2
  • Ahmet Altinbas
    • 2
  • Simge Varol
    • 3
  1. 1.Alanya State HospitalAntalyaTurkey
  2. 2.Department of Cardiology, Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey
  3. 3.Department of Geology, Faculty of EngineeringSuleyman Demirel UniversityIspartaTurkey

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