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Biological Trace Element Research

, Volume 142, Issue 2, pp 127–129 | Cite as

Reversible Hypomagnesaemia-Induced Subacute Cerebellar Syndrome

  • Saam SedehizadehEmail author
  • Michael Keogh
  • Adrian J. Wills
Article

Abstract

Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbeat nystagmus, cerebellar ataxia, generalised convulsions and a supraventricular tachycardia. On MRI imaging, a transient lesion of the cerebellar nodulus was observed, which has not, to our knowledge, been previously described in isolated hypomagnesaemia.

Keywords

Cerebellar ataxia Metabolic disease Hypomagnesaemia 

Notes

Competing interest

None declared.

References

  1. 1.
    Leigh RJ (1992) Clinical features and pathogenesis of acquired forms of nystagmus. In: Buttner U, Brandt T (eds) Ocular motor disorders of the brainstem, Bailliere’s clinical neurology. Balliere Tindall, London, pp 393–416Google Scholar
  2. 2.
    Saul RF, Selhorst JB (1981) Downbeat nystagmus with magnesium depletion. Arch Neurol 38:650–652PubMedGoogle Scholar
  3. 3.
    Du Pasquier R, Vingerhoets F et al (1998) Periodic downbeat nystagmus. Neurology 51:1478–1480PubMedGoogle Scholar
  4. 4.
    Yasuhiro I, Yutaka A et al (1998) Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome. Am J Neuroradiol 10:415–417Google Scholar
  5. 5.
    Hauben M (1996) Cyclosporin neurotoxicity (review). Pharmacotherapy 16:576–583PubMedGoogle Scholar
  6. 6.
    Thompson CB, June CH et al (1984) Association between cyclosporine neurotoxicity and hypomagnesaemia. Lancet 2:1116–1120PubMedCrossRefGoogle Scholar
  7. 7.
    Al-Rasheed AK, Blaser SI et al (2000) Cyclosporine A neurotoxicity in a patient with idiopathic renal magnesium wasting. PediatrNeurol 23:353–356Google Scholar
  8. 8.
    Gorman DJ, Kefford R et al (1989) Focal encephalopathy after cisplatin therapy. Med J Aust 150:399–401PubMedGoogle Scholar
  9. 9.
    Nomura K, Ohno R (1995) Clinicopathological report of cisplatin encephalopathy. Clin Neurol 35:64–69Google Scholar
  10. 10.
    Glaudemans B, Van der Wijst J et al (2009) A missense mutation in the Kv1.1 voltage gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin Invest 119:936–942PubMedCrossRefGoogle Scholar
  11. 11.
    Nunez L, Sanchez A et al (1996) Mechanisms for synchronous calcium oscillations in cultured rat cerebellar neurons. Eur J Neurosci 8:192–201PubMedCrossRefGoogle Scholar
  12. 12.
    Walker MF, Tian J (2008) Lesions of the cerebellar nodulus and uvula impair downward pursuit. J Neurophysiol 100:1813–1823PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Saam Sedehizadeh
    • 1
    Email author
  • Michael Keogh
    • 2
  • Adrian J. Wills
    • 1
  1. 1.Department of Neurology, Queens Medical CentreNottingham University Hospitals NHS TrustNottinghamUK
  2. 2.Department of NeurologyNewcastle Upon Tyne Hospitals NHS TrustNewcastle Upon TyneUK

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