Biological Trace Element Research

, Volume 134, Issue 2, pp 180–187 | Cite as

Selenium and Cadmium Levels and Ratios in Prostates, Livers, and Kidneys of Nonsmokers and Smokers

  • Jutta Schöpfer
  • Gustav Drasch
  • Gerhard N. Schrauzer
Article

Abstract

Cadmium (Cd) from cigarette smoke, environmental, and nutritional sources accumulates in the human prostate where it interacts with selenium (Se) in a manner suggesting the formation of a 1:1 Cd–Se–protein complex. At low Cd exposures and adequate Se status, this interaction may be beneficial as it results in the detoxification of Cd. At higher exposures, Cd may weaken or abolish the anticarcinogenic effects of Se and increase prostate cancer risk. In some older men and especially in smokers, Cd levels in prostates reach levels in stoichiometric excess over Se, which may be the reason why heavy smokers are at higher risk of developing lethal forms of prostate cancer. In the liver and the kidneys, Cd accumulates as well, but in these organs, Cd is efficiently sequestered through metallothionein formation. In the prostate, this mode of detoxification is not available or less efficient, causing Cd to interact with Se and to increase prostate cancer risk.

Keywords

Cadmium Selenium Prostate Liver Kidneys Smokers Nonsmokers 

References

  1. 1.
    National Toxicology Program (2007) Eleventh report on carcinogens. National Toxicology Program, Washington, DCGoogle Scholar
  2. 2.
    Agency for Toxic Substances and Disease Registry (1997) Division of Toxicology, Agency for Toxic Substances and Disease Registry, Public Health Service. U.S. Department of Health and Human Services, AtlantaGoogle Scholar
  3. 3.
    Jamba L, Nehru B, Bansal MP (1997) Selenium supplementation during cadmium exposure: changes in antioxidant enzymes and the ultrastructure of the kidney. J Trace El Exp Med 10:233–242CrossRefGoogle Scholar
  4. 4.
    Vinceti M, Venturelli M, Sighinolfi C, Trerotoli P, Bonvicini F, Ferrari A, Bianchi G, Serio G, Bergomi M, Vivoli G (2007) Case control study of toenail cadmium and prostate cancer risk in Italy. Sci Total Environ 373:77–81CrossRefPubMedGoogle Scholar
  5. 5.
    Benbrahim-Tallaa L, Lio J, Webber NN, Waalkes MP (2007) Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells. Prostate 67:135–145CrossRefPubMedGoogle Scholar
  6. 6.
    Achanzar WE, Diwan BA, Liu J, Quader ST, Webber MM, Waalkes MP (2001) Cadmium-induced malignant transformation of human prostate epithelial cells. Cancer Res 61:455–458PubMedGoogle Scholar
  7. 7.
    Zeng X, Jin T, Jiang X, Kong Q, Ye T, Nordberg GF (2004) Effects on the prostate of environmental cadmium exposure—a cross-sectional population study in China. Biometals 17:559–566CrossRefPubMedGoogle Scholar
  8. 8.
    Bremner I (1978) Cadmium toxicity. World Ref Nutr Diet 32:165–197Google Scholar
  9. 9.
    Schrauzer GN (2008) Interactive effects of selenium and cadmium on mammary tumor development and growth in MMTV-infeced female mice. A model study on the roles of cadmium and selenium in human breast cancer. Biol Trace El Res 123:27–34CrossRefGoogle Scholar
  10. 10.
    Drasch G, Schöpfer J, Schrauzer GN (2005) Selenium/cadmium ratios in human prostates. Biol Trace El Res 103:103–107CrossRefGoogle Scholar
  11. 11.
    Coughlin SS, Neaton JD, Sengupta A (1996) Cigarette smoking as a predictor of death. Am J Epidemiol 143:1002–1006PubMedGoogle Scholar
  12. 12.
    Plaskon LA, Penson DF, Vaughan TL, Stanford JL (2003) Cigarette smoking and risk of prostate cancer in middle-aged men. Cancer Epidemiol Biomarkers Prev 12(7):604–609PubMedGoogle Scholar
  13. 13.
    Klaassen CD, Liu J, Diwan BA (2009) Metallothionein protection of cadmium toxicity. Toxicol Appl Parmacol 238:215–220CrossRefGoogle Scholar
  14. 14.
    Lee JD, Wu SM, Lu LY, Yang YT, Jeng SY (2009) Cadmium concentration and metallothionein expression in prostate cancer and benign prostatic hyperplasia of humans. J Formosan Medical Ass = Taiwan yi zhi 108:554–559CrossRefGoogle Scholar
  15. 15.
    Nichiyama S, Onosaka S, Okudaira M, Yamamoto H, Tanaka K (2003) Dietary cadmium inhibits spontaneous hepatocarcinogenesis in C3H/HeN nice and hepatitis in A/J mice but not in C57/Bl6 mice. Toxicol Appl Pharmacol 186:1–6CrossRefGoogle Scholar
  16. 16.
    Gaddipati JP, Rajeshkumar NV, Grove JC, Maharaj SVM, Centeno JA, Maheshwari RK, Jones WB (2003) Low-dose cadmium exposure reduces human prostate cell transformation in culture and upregulates metallothionein and MT-IG mRNA. Nonlinearity Biol Toxicol Med 1:199–212CrossRefPubMedGoogle Scholar
  17. 17.
    Schrauzer GN, White DA, Schneider CA (1977) Cancer mortality correlation studies. IV. Associations with dietary intakes and blood levels of certain trace elements, notably Se-antagonists. Bioinorg Chem 7:35–56CrossRefPubMedGoogle Scholar
  18. 18.
    Schwarz K, Spallholz T (1976) Growth effects of small cadmium supplements in rats maintained under trace element-controlled conditions. Abstr Fed Proc 35:255Google Scholar
  19. 19.
    Anke M, Hennig A, Groppel B, Partschfeld M, Grün M (1978) The biochemical role of cadmium. In: Kirchgessner M (ed) Proceedings of the third international symposium on trace element metabolism in man and animals. Technische Universitat Munchen, Freising-Weihenstephan, pp 450–548Google Scholar
  20. 20.
    Anke M, Dorn W, Müller M, Seifert M (2005) Recent progress in exploring the essentiality of the ultratrace element cadmium to the nutrition of animals and man. Biomed Res Trace Elem 16:198–202Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jutta Schöpfer
    • 1
  • Gustav Drasch
    • 1
  • Gerhard N. Schrauzer
    • 2
    • 3
  1. 1.Institut für RechtsmedizinLudwig-Maximillians UniversitätMunichGermany
  2. 2.Biological Trace Element Research InstituteChula VistaUSA
  3. 3.Department of Chemistry and BiochemistryUniversity of CaliforniaSan DiegoUSA

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