Biological Trace Element Research

, Volume 137, Issue 3, pp 335–339

Diminished Selenium Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

  • Maryam Pakfetrat
  • Leila Malekmakan
  • Mahshid Hasheminasab
Article

DOI: 10.1007/s12011-009-8588-2

Cite this article as:
Pakfetrat, M., Malekmakan, L. & Hasheminasab, M. Biol Trace Elem Res (2010) 137: 335. doi:10.1007/s12011-009-8588-2

Abstract

In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy volunteers. The observed Se levels of 100.8 ± 51.9 µg/L in the sera of the HD patients and of 65.5 ± 32.1 µg/L in the sera of the CAPD patients were significantly lower than the 134.9 ± 81.2 µg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients (p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy persons are attributed to diminished Se retention due to chronic oxidative stress.

Keywords

Hemodialysis Peritoneal dialysis Selenium 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maryam Pakfetrat
    • 1
  • Leila Malekmakan
    • 1
  • Mahshid Hasheminasab
    • 1
  1. 1.Shiraz Nephro-Urology Research CenterShiraz University of Medical SciencesShirazIran

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