Serum Trace Element Levels in Febrile Convulsion
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Febrile convulsion is the most common disorder in childhood with good prognosis. There are different hypotheses about neurotransmitters and trace element changes in biological fluids which can have a role in pathogenesis of febrile convulsion. In this study, serum selenium, zinc, and copper were measured by atomic absorption spectrometry in the children with febrile convulsion (n = 30) and in the control group (n = 30). The age and sex of the subjects were registered. Selenium and zinc were found to be significantly lower in febrile convulsion cases than in the control group (p < 0.0001 and p < 0.0001, respectively). There was no significant difference in the value of copper between the two groups (p = 0.16). While selenium and zinc levels were 44.92 ± 10.93 μg/l and 66.13 ± 18.97 μg/dl in febrile convulsion, they were found to be 62.98 ± 9.80 μg/l and 107.87 ± 28.79 μg/dl in healthy children. Meanwhile, copper levels were 146.40 ± 23.51 μg/dl in the patients and 137.63 ± 24.19 μg/dl in the control group, respectively. This study shows that selenium and zinc play an important role in the pathogenesis of febrile convulsion.
KeywordsFebrile convulsion Serum Selenium Zinc Copper
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