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Biological Trace Element Research

, Volume 135, Issue 1–3, pp 38–44 | Cite as

Serum Trace Element Levels in Febrile Convulsion

  • Mojtaba AmiriEmail author
  • Leila Farzin
  • Mohammad Esmail Moassesi
  • Fattaneh Sajadi
Article

Abstract

Febrile convulsion is the most common disorder in childhood with good prognosis. There are different hypotheses about neurotransmitters and trace element changes in biological fluids which can have a role in pathogenesis of febrile convulsion. In this study, serum selenium, zinc, and copper were measured by atomic absorption spectrometry in the children with febrile convulsion (n = 30) and in the control group (n = 30). The age and sex of the subjects were registered. Selenium and zinc were found to be significantly lower in febrile convulsion cases than in the control group (p < 0.0001 and p < 0.0001, respectively). There was no significant difference in the value of copper between the two groups (p = 0.16). While selenium and zinc levels were 44.92 ± 10.93 μg/l and 66.13 ± 18.97 μg/dl in febrile convulsion, they were found to be 62.98 ± 9.80 μg/l and 107.87 ± 28.79 μg/dl in healthy children. Meanwhile, copper levels were 146.40 ± 23.51 μg/dl in the patients and 137.63 ± 24.19 μg/dl in the control group, respectively. This study shows that selenium and zinc play an important role in the pathogenesis of febrile convulsion.

Keywords

Febrile convulsion Serum Selenium Zinc Copper 

References

  1. 1.
    Burhanoglu M, Tutuncuoglu S, Coker C, Tekgul H, Ozgur T (1996) Hypozincaemia in febrile convulsion. Eur J Pediatr 155:498–501CrossRefPubMedGoogle Scholar
  2. 2.
    Garty BZ, Olomucki R, Lerman-Sagie T, Nitzan M (1995) Cerebrospinal fluid zinc concentrations in febrile convulsions. Arch Dis Child 73:338–341CrossRefPubMedGoogle Scholar
  3. 3.
    Tay JSH, Yip WCL, Josef R, Wong HB (1985) Parental age and birth order effects in children with febrile convulsions. Eur J Pediatr 144:88–89CrossRefPubMedGoogle Scholar
  4. 4.
    Vural H, Uzan K, Uz E, Kocyigit A, Cigli A, Akyol O (2000) Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma. J Trace Elem Med Biol 14:88–91CrossRefPubMedGoogle Scholar
  5. 5.
    Arcasoy A, Canatan D, Sinav B, Kutlay L, Nurgul O, Muhtar S (2001) Serum zinc levels and zinc binding capacity in thalassemia. J Trace Elem Med Biol 15:85–87CrossRefPubMedGoogle Scholar
  6. 6.
    Johannessen JK, Gammelgaard B, Jons O, Hansen SH (1993) Comparison of chemical modifiers for simultaneous determination of different selenium compounds in serum and urine by Zeeman-effect electrothermal atomic absorption spectrometry. J Anal At Spectr 8:999–1004CrossRefGoogle Scholar
  7. 7.
    Hugen CAC, Oudesluys-Murphy AM, Hop WCJ (1995) Serum sodium levels and probability of recurrent febrile convulsions. Eur J Pediatr 154:403–405CrossRefPubMedGoogle Scholar
  8. 8.
    Freeman JM (1980) Febrile seizures: a consensus of their significance, evaluation, and treatment. Pediatrics 66:1009–1012PubMedGoogle Scholar
  9. 9.
    Peter S, Koh J, Choi W (1987) Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 236:589–593CrossRefGoogle Scholar
  10. 10.
    Johnson DD, Wilcox R, Tuchek JM, Crawford RP (1985) The anticonvulsant effect of elevated gamma-aminobutyric acid concentrations. Epilepsia 26:466–471CrossRefPubMedGoogle Scholar
  11. 11.
    Loscher W (1982) Relation between GABA concentration in cerebrospinal fluid and seizure excitability. Jf Neurochem 38:293–295CrossRefGoogle Scholar
  12. 12.
    Manyam NV, Katz L, Hare TA, Gerber JC, Grossman MH (1980) Levels of gammaaminobutyric acid in cerebrospinal fluid in various neurological disorders. Arch Neurol 37:352–355PubMedGoogle Scholar
  13. 13.
    Loscher W, Rating D, Siemes H (1981) GABA concentration in cerebrospinal fluid of children with febrile convulsions. Epilepsia 22:697–702CrossRefPubMedGoogle Scholar
  14. 14.
    Tutuncuoglu S, Kutukculer N, Kepe L, Coker C, Berdeli A, Tekguel H (2001) Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions. Pediatr Int 43:235–239CrossRefPubMedGoogle Scholar
  15. 15.
    Mollah MAH, Ranjan Dey P, Tarafdar SA, Akhter S, Ahmed S, Hassan T, Ara Begum N, Nahar N (2002) Zinc in CSF of patients with febrile convulsion. Ind J Pediatr 69:859–861CrossRefGoogle Scholar
  16. 16.
    Ganesh R, Janakiraman L (2008) Serum zinc levels in children with simple febrile seizure. Clin Pediatr 47:164–166CrossRefGoogle Scholar
  17. 17.
    Ehsanipour F, Talebi-Taher M, Vahid-Harandi N, Kani K (2009) Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iran J Pediatr 19:65–68Google Scholar

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Mojtaba Amiri
    • 1
    Email author
  • Leila Farzin
    • 1
  • Mohammad Esmail Moassesi
    • 1
  • Fattaneh Sajadi
    • 1
  1. 1.Environmental Laboratory, Nuclear Science Research School, Nuclear Science & Technology Research InstituteAtomic Energy Organization of Iran (AEOI)TehranIran

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