Biological Trace Element Research

, 132:122

Decreased Percentages of the Peripheral Blood T-Cell Subsets and the Serum IL-2 Contents in Chickens Fed on Diets Excess in Fluorine

  • Tao Chen
  • Yun Cui
  • Caimin Bai
  • Tao Gong
  • Xi Peng
  • Hengmin Cui
Article

DOI: 10.1007/s12011-009-8373-2

Cite this article as:
Chen, T., Cui, Y., Bai, C. et al. Biol Trace Elem Res (2009) 132: 122. doi:10.1007/s12011-009-8373-2

Abstract

Three hundred 1-day-old Avian broilers were divided into four groups and fed on control diet (F 23 ppm) and high-fluorine diets (400 ppm, high-fluorine group I; 800 ppm, high-fluorine group II; 1,200 ppm, high-fluorine group III) for 42 days (n = 75/group). The percentages of CD4+ and CD8+ T cells were decreased in three high-fluorine groups when compared with those of control group. Meanwhile, the CD4+/CD8+ ratio were lower in high-fluorine group II at 28 days of age and in high-fluorine group III at 42 days of age than in control group. Also, the serum interleukin-2 (IL-2) contents were decreased in three high-fluorine groups when compared with those of control group. Histopathologically, the thymus became hypocellular in three high-fluorine groups. It was concluded that dietary fluorine excess (400~1,200 ppm) reduced the percentages of T-lymphocyte subsets and the serum IL-2 contents, and cellular immune function could be affected in chickens.

Keywords

Fluorine excess CD4 CD8 IL-2 Flow cytometry (FCM) Broilers 

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Tao Chen
    • 1
  • Yun Cui
    • 1
  • Caimin Bai
    • 1
  • Tao Gong
    • 1
  • Xi Peng
    • 1
  • Hengmin Cui
    • 1
  1. 1.College of Veterinary MedicineSichuan Agricultural UniversityYa’anChina

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